Switching from Mounjaro to Retatrutide Dosage Advice

1 mg of reta is quite low. I didn’t notice much until I reached 1.5 mg. What’s your goal, big weight loss or mostly body recomp? I’d try going up slowly first, maybe a week at 1.25 then 1.5. If you still need to drop a lot of weight then adding cagri could help, but reta works well by itself once you hit the right level. At 2 mg now I already feel full most of the day. If you’re hitting a high daily protein target I wouldn’t add cagri.

I want to lose another 10 kg. That’s the goal. I began at 1 mg just to test the effect but my appetite is still very strong.

Since you’ve already used other GLP-1s it makes sense to raise reta gradually. The usual starting clinical dose is 2 mg. New users sometimes respond at lower amounts but you clearly aren’t one of them. A concentration tracker can help you find the right level as you go up. It takes four weeks to reach peak concentration. Are you dosing every seven days? I’ve found splitting the dose keeps appetite down better and lowers side effects. A 3.5-day cycle might work well. I’m nine weeks in as a first-timer, very responsive, and now at 1.5 mg weekly split into two 0.75 mg shots. Appetite is well controlled and I’m losing about two pounds a week. You could try 2 mg split as 1 mg every 3.5 days for a couple of weeks.

I’ve done four-week cycles at 2 mg, then 4 mg, and just started 5 mg. I was going to try 6 mg but I’m already losing 2.5 lb a week on average. I’ll check the scale after four weeks at 5 mg. I’m not mixing anything else, just reta.

The advice above seems reasonable. If you raise doses faster than every four weeks, smaller and more frequent shots can reduce long-lasting side effects. It would help to know what side effects you had on semaglutide. You said 2.5 mg of tirzepatide didn’t do much but 5 mg was never repeated, which is confusing. What exactly happened at 5 mg of tirzepatide? That matters because if it caused problems you’re probably sensitive and should increase more carefully and slowly. Jumping straight to 2 mg of reta is unlikely to be an issue, but after that I wouldn’t go from 2 mg to 4 mg; I’d go to 3 mg and then up by 1 mg at a time. The most common side effects are gut related, mainly nausea, and they usually improve slowly over months.

I have to guess a lot without basics like starting BMI, weight, age, or sema dose. You’ve already lost 30 kg and want 10 more, so roughly 40 % total loss, which is better than average even on full-dose reta. Responses vary but you seem to respond well. Reta is the strongest for weight loss, about 5 % better than tirz, while tirz tends to have the fewest side effects. Either one should probably get you to goal given your history. The current reta dose is still too low to judge side effects. So keep going with reta since you’ve started or switch back to tirz. Without age and medical history it’s hard to say for sure, but long-term you might do best on the highest doses of either.

My first week on 2.5 mg reta was rough. Sleep problems and no appetite control. For the first time in six clean months I binged and then vomited badly. I had to pin 2.5 TR to stop it. That helped a bit. My highest dose was 5 mg of MJ and I’m now maintaining at 55 kg after losing 30 kg. I eat over 100 g protein and about 1400 kcal daily plus 17 000 steps. Weight has been stable for almost a month.

Beginning fresh using this option my plan would involve starting at a low amount to drop or hold steady on body mass then raising it bit by bit over weeks. Pursuing intense hunger pangs by mixing in extra compounds holds no appeal for me. I avoid seeking the lack of eating cues as though it were some kind of rush. After moving across to this choice my meals increased just a touch yet the scale kept moving downward and that outcome suited me fine. Taking things slow while raising the level gradually paid off.

Started at 296 lb on 2.5 mg tirz in Oct 2024. Dropped to 216 lb after going up to 15 mg over a year until Nov 2025 when I stalled for two months. Switched to reta in Jan at 2 mg for four weeks then 4 mg for four weeks. Lost 3 lb to 213 but stalled again. Was about to go to 6 mg but read about micro-dosing so I started 3 mg every other day two weeks ago and dropped another 4 lb quickly. I also take 0.5 mg cagri once a week mid-week. Now at 209 lb from 296 lb starting weight. Goal is 190 lb, which I think I can reach by summer.

Previously I took the five milligram amount of that medication without any trouble at all. Then I tried the initial one milligram amount of this new compound starting from the evening after and lasting until the third day afterward I dealt with constant stomach and intestinal discomfort. It caught me off guard that this occurred even with the smaller quantity. My plan was to use the next one the following Friday but now I can't decide if I should return to the previous medication or stick with this same small amount for one more week.

I forgot to add that the GI symptoms have been fairly easy to manage with fiber and magnesium for constipation plus plenty of fluids.

I’ve heard people say the glucagon effect doesn’t start until 4 mg, stated like fact. I’m pretty sure that’s just gym-bro logic and can be ignored.

I maintained five milligrams weekly through most of that stretch. Over the past several months I raised it to ten. Within eight months I reached the total weight reduction I had set as my goal, equal to a quarter of my original body mass. Later blood work showed standard liver values, so the physician removed the fatty liver note from my file.

Quick question. I injected 1 mg yesterday by mistake when I meant to do 1.5 mg for the first time. Can I inject another 0.5 mg today, one day later? Or should I just do another full 1 mg for a 2 mg total?