Peptide, GLP-1 & TRT half-life chart
A cited half-life chart for 26 peptides and hormones — grouped by class, each with the time to ~97% clearance and a computed decay curve. Every value cites a primary source; if you find a better one, tell us — corrections are published, never silent.
Looking for a compound that isn't here? Many research peptides have no published half-life. See all 62 compounds we cover, A–Z →
Every decay curve shares one time axis (0 → ≈ 44 days, the longest single-dose clearance here). The dashed horizontal line marks 50%; the dotted vertical marks that compound's half-life (t½) — where the curve crosses 50%. A t½ marker far to the right means a slow, lingering drug; one hugging the left clears fast. Open any compound for the full-size curve and its primary source.
GLP-1 & incretin agonists
| Compound | Half-life | ~97% cleared | Single-dose decay |
|---|---|---|---|
| Mazdutide half-life | ≈ 8 days | ≈ 40 days | |
| Cagrilintide half-life | ≈ 7–8 days | ≈ 37.5 days | |
| Semaglutide half-life | ≈ 7 days | ≈ 35 days | |
| Retatrutide half-life | ≈ 6 days | ≈ 30 days | |
| Survodutide half-life | ≈ 6 days | ≈ 30 days | |
| Tirzepatide half-life | ≈ 5 days | ≈ 25 days | |
| Liraglutide half-life | ≈ 13 h | ≈ 2.7 days |
Metabolic & fat loss
| Compound | Half-life | ~97% cleared | Single-dose decay |
|---|---|---|---|
| AOD-9604 half-life | ≈ 3 min (IV, porcine) | ≈ 0.3 hours |
Growth-hormone & IGF axis
| Compound | Half-life | ~97% cleared | Single-dose decay |
|---|---|---|---|
| CJC-1295 half-life | ≈ 8 days | ≈ 40 days | |
| IGF-1 LR3 half-life | ≈ 20–30 h | ≈ 5 days | |
| MK-677 half-life | ≈ 24 h | ≈ 5 days | |
| Ipamorelin half-life | ≈ 2 h | ≈ 10 hours | |
| Tesamorelin half-life | ≈ 26–38 min | ≈ 3.2 hours | |
| GHRP-2 half-life | ≈ 30 min | ≈ 2.5 hours | |
| GHRP-6 half-life | ≈ 15–30 min | ≈ 2 hours |
Recovery, repair & longevity
| Compound | Half-life | ~97% cleared | Single-dose decay |
|---|---|---|---|
| TB-500 half-life | ≈ 2–3 days | ≈ 12.5 days | |
| BPC-157 half-life | ≈ 4–6 h | ≈ 1 days | |
| SS-31 (Elamipretide) half-life | ≈ 4 h | ≈ 20 hours | |
| Thymosin Alpha-1 half-life | ≈ 2 h | ≈ 10 hours | |
| GHK-Cu half-life | ≈ 30 min | ≈ 2.5 hours |
Neuro & cognitive
| Compound | Half-life | ~97% cleared | Single-dose decay |
|---|---|---|---|
| Dihexa half-life | ≈ 8.8 days (rat) | ≈ 44.2 days |
TRT & hormonal support
| Compound | Half-life | ~97% cleared | Single-dose decay |
|---|---|---|---|
| Testosterone Cypionate half-life | ≈ 8 days | ≈ 40 days | |
| Anastrozole half-life | ≈ 46 h | ≈ 9.6 days | |
| HCG half-life | ≈ 33 h | ≈ 6.9 days | |
| Gonadorelin half-life | ≈ 10–40 min | ≈ 2 hours |
Other peptides
| Compound | Half-life | ~97% cleared | Single-dose decay |
|---|---|---|---|
| PT-141 half-life | ≈ 2.7 h | ≈ 13.5 hours |
New to half-lives?
Start with the concepts, then come back to any compound above. These explain what the numbers in the chart actually mean for timing and accumulation.
Frequently asked
What is a half-life, and why does it matter for peptides?
A compound's half-life is the time its level in the body falls by half. After about five half-lives, roughly 97% of a single dose has cleared. It sets how long a peptide keeps acting and how often published studies dose it — a short half-life means frequent dosing, a long one means weekly or less.
Which peptide has the longest half-life?
Of the compounds tracked here, Dihexa has the longest reported half-life at ≈ 8.8 days (rat) (212 hours), while AOD-9604 is among the shortest at ≈ 3 min (IV, porcine). The chart above ranks each class from longest to shortest.
How long do GLP-1 medications stay in your system?
Weekly GLP-1 and incretin drugs have multi-day half-lives — Semaglutide ≈ 35 days and Tirzepatide ≈ 25 days to ~97% clearance from a single dose. With steady weekly dosing, levels stay elevated continuously rather than washing out between doses — that is steady-state accumulation.
How do I read this half-life chart?
Each row lists a compound's reported half-life, the time for a single dose to reach ~97% clearance (five half-lives), and a decay-curve preview. Open any compound for the full curve and its primary source. Every number we publish cites a source and is versioned when it changes.
See your own estimated levels
The Zyra Track app plots these curves from the doses you actually log — accumulation, overlaps, and all. Free during the founding period.
Zyra Track is a research and educational utility. Nothing on this page is medical advice, a dosing recommendation, or an endorsement of any compound. We never sell or source compounds and refuse sourcing questions. Consult a qualified clinician for decisions about your health.