With everything happening lately I wanted to know what stopping actually does. Does it cause withdrawal? I've read the articles about weight coming back but I'm interested in how the whole experience feels day to day.
Have you stopped taking your GLP, and if so what happened?
What happens to weight, appetite, and other symptoms when stopping GLP-1 medications?
Most people report weight regain, return of hunger and cravings, and sometimes inflammation or pain within days or weeks of stopping. A few maintain with lifestyle changes, other medications like Contrave, or lower doses, but many view these drugs as long-term treatment for metabolic issues. Experiences vary widely, including cases of anxiety or vision concerns prompting stops, and restarts often lead to quick loss again. Some emphasize that the drugs affect more than just calories in versus out.
What this discussion establishes- Weight regain of 10-20+ pounds is common within weeks or months off the meds
- Hunger, food noise, and cravings for sweets often return strongly
- Inflammation, pain, and metabolic issues frequently reappear quickly
- Some switch to alternatives like Contrave or metformin to help maintain
- A minority keep weight stable through strict tracking or other compounds
- Vision changes or anxiety led a few to stop permanently
Whether weight changes are purely due to calorie intake or if the medications alter metabolism, fat composition, and other factors beyond appetite in ways that make simple CICO insufficient.
Still openWhether true withdrawal symptoms exist beyond hunger return, long-term outcomes after stopping, and how to best transition off for those who must or choose to.
Nothing here is advice.
I put back on ten of the twenty pounds I had lost. The food thoughts returned and now I'm trying to figure out a new normal.
I started right when it first became available and stayed on for ten or eleven months, dropping about ninety pounds. My aim was to get healthy enough for pregnancy. Insurance stopped covering the discount so I had to quit. I got pregnant about six weeks later. I can't say how typical that is because pregnancy was involved. While on it I only ate when hungry and rarely felt hungry, averaging around a thousand calories a day. Before finishing my last box I tried to eat closer to maintenance levels, aiming for fifteen hundred or more on some days, and kept carbs low but not zero. That helped me hold my weight steady at the end.
After quitting you need to learn proper eating and keep exercising if you want to hold a healthy weight, though that's easier said than done.
Both of my pregnancies plus breastfeeding led to big gains and after the second one I never returned to my previous weight. I understand what you went through.
I gained weight and when I tried again later the medication didn't seem to work as strongly.
I paused briefly while switching from one to another. Appetite rose and I followed a strict plan so I wouldn't gain, but the cravings for sweets hit hard. All I could think about was the candy drawer at home.
Remember these medications do more than just reduce appetite. All the other benefits go beyond simply being able to eat the same amount of food without them.
That's exactly what I'm wondering about, especially the dopamine side. I heard they boost dopamine which is why cravings disappear. If I ever have to stop or it gets too hard to stay on, will there be withdrawal? And what happens if you restart later?
For me inflammation returns strongly and I start gaining within days of missing a dose. Once I went thirteen days between shots and gained six pounds; I'm still working to recover. A lot of us use these for metabolic problems, so when you stop treating them the issues come back. I see this as a lifetime medication for most people. If I were diabetic I'd take insulin forever, so how is this different? Beyond weight these meds took away about ninety percent of my chronic pain and gave me a better life. I'll keep taking them as long as I can get them.
Did you restart or are you trying to manage without it?
I needed a different source and couldn't reach my goal weight again, so I switched to another medication and a different source.
I have to pause for ten days ahead of surgery and today would normally be my shot day. Surgery is Monday the twenty-ninth and I'm not looking forward to this stressful week without my usual support. Stopping for good doesn't seem realistic to me. I plan to lower the dose once I reach goal and stay on a small amount long term.
Other places handle post-treatment weight maintenance better than we do. Counseling helps and some doctors add metformin or another combination medication, which has kept weight off for patients. Four people I'm counseling are doing well on that combination; two even lost a bit more after switching. I have diabetes and hope to stay on these medications lifelong because they control my glucose so well. If I ever can't continue I'll switch to the combination or possibly just one component alone.
That's what concerns me about stopping since I still have a stone or so left. I'm on ten milligrams now but don't know whether to go higher or add something else. At least I have options, which is fortunate.
That's exactly why I won't be able to stop either. The inflammation and pain would return.
If you're still dropping half a pound to two pounds a week, keep going. After two or three weeks with no change I'd increase the dose since you handle it fine. Just my thoughts.
Hopefully the long half-life will cover you for most of the gap.
Yeah, hopefully. It was supposed to be at least ten days but since I dose on Sundays it will actually be a full fifteen days by the time surgery day ends.
It's a lifelong thing so don't stress too much over a short interruption. Good luck.
Yeah I think I'll do that, thanks. Right now I'm losing about three to four pounds a month so that feels about right.
Oh I know. I've been working on weight for nearly two years and I'm down one hundred thirty-six pounds. Still, I'm not looking forward to the hunger that will probably hit midweek.
I'd suggest raising your dose gradually as long as you keep tolerating it.
I've been off for two months with almost no weight gain. I've been using another compound at two hundred fifty to five hundred milligrams which has helped control appetite and energy. I'm holding at one hundred seventy; if I go over one hundred seventy-five I take one shot of the medication maybe once a month and that brings me back down.
I used one medication from November twenty-four to April twenty-five and lost twenty-one pounds. After stopping for about two months I gained fifteen back, which is a lot for me since I usually gain only three or four pounds a year during gaining phases. That was concerning. The positive side is I lost thirteen pounds in the first week after restarting with a different medication. I'm now down thirty-two pounds this year and have over two years' worth of yet another medication stocked up.
I couldn't get my next dose for seven days. Hunger was intense but I kept to my normal calories and exercise and still gained ten pounds. How does that even happen? These medications affect the body in many ways beyond just appetite. My lipedema swelling seemed to return right away. I'm not sure I'll ever be able to stay off if I want to keep a healthy weight.
I felt very hungry on the new medication and at the higher dose I got unbearable diarrhea, so I'm back on the previous two stacked together. That helps me maintain and somewhat controls food thoughts.
My brother lost vision in one eye, apparently from one of these medications, so he's been off since June and won't risk the other eye. Since stopping he's gained twenty pounds. He claims he's eating the same as before but I'm a bit doubtful since I don't see him often. Now he's feeling low and depressed and plans to exercise more to try to stop the gain.
People have told me my whole life that it's just calories in versus calories out. If that were true I wouldn't have needed the medication in the first place. Plenty of research shows these drugs help with insulin resistance and other issues and can even change fibrotic fat in certain conditions. More study is needed on all the ways they work. I'm proof that calorie balance alone doesn't always determine weight loss.
I'm in a twelve-step program for overeating which has changed my life around binge eating and bulimia. I want both the mental peace and the physical results. This medication is just one tool among several; I can't depend on it completely.
Calories in versus calories out has turned out to be mostly accurate according to many studies, though nutritionists can point out lots of ways you might affect the output side without realizing it. One of these medications was tested and showed little impact on overall metabolism. People are usually bad at remembering exactly what they ate. Serious bodybuilders are an exception because they track precisely when changing weight on purpose. I think he genuinely believes he's eating the same. I had to stop one medication recently due to possible liver issues and will probably restart soon. On the current one alone I don't feel like I'm overeating yet the scale keeps rising. How food feels isn't a reliable measure. Accurate daily records give real information but few people keep them consistently.
I've kept detailed food diaries not just for myself but for my daughter who's in a national health program that requires it. I've worked with dietitians, nutritionists, and a specialist endocrine team for two years. They're researching genetic obesity with testing. My body composition suggests I should maintain on sixteen hundred calories, but after months we've seen that's not true. It can stem from several factors, likely including genetic fat storage plus lipedema and PCOS. That also doesn't account for the aerobic work and core training I do, so in theory I should eat more without gaining, but again the theory didn't hold. We're hoping the research will clarify genetic obesity and identify the genes. It's been revealing. Almost all patients gain some weight after stopping these medications, though diet explains only part of it.
If you don't mind a few questions I'm curious about these cases. Was he diabetic, prediabetic, or neither? Was the loss at a steady one to two pounds a week or faster? Any warning signs before the vision changed? Do you think anything else might have played a role besides the medication?
It's good that these medications exist to help. Often though more than one approach is needed.
The only detail I know for sure is there were no warning signs. He woke up one morning with vision problems. It affects everything: balance, dizziness from using one eye, headaches. He's joined the lawsuit. I don't think other factors were involved. It happened in June after about a year on the medication and he'd lost around sixty pounds.
Recent research connects these GLP-1 medications used for diabetes and weight loss to a rare eye condition that can lead to vision loss.
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