CommunityMind & Motivation

Advice on dealing w/ anhedonia on Tirz

5 replies6 peopleMar 12, 2026☆ Follow
Summary

how to handle anhedonia while taking tirzepatide

Users report anhedonia on tirzepatide that may stem from dopamine suppression or from weight loss and lower calories. One person found symptoms eased after several months as the brain adjusted to non-food rewards. Another combines the medication with cannabis to restore some dopamine. A third notes data shows no rise in depression rates and suggests behavioral activation or switching compounds if symptoms persist.

What this discussion establishesWhere people disagree

whether anhedonia is caused directly by tirzepatide or mainly by reduced calorie intake and weight loss

Still open

which approaches reliably reduce anhedonia for most people

Nothing here is advice.

5 replies · 6 people
SteadyQuill60archiveopening postMar 12

Tirzepatide lowers dopamine and that removes food noise along with the dopamine hit from looking forward to eating. It works well for me but leaves me with anhedonia so I have little interest in things I used to like. Curious if anyone has found ways to lessen this side effect.

SteadyQuill55archiveMar 12

I held on for a while. Eventually my mind seemed weary of moping alone and craving extra pleasure chemicals, labeling everything else as insufficiently enjoyable. Then it accepted that eating wouldn't deliver those feelings anymore, and began encouraging me toward alternative activities. These days I engage in many different pursuits and feel content once more, though the process lasted several months.

WarmSparrow60archiveMar 12

I add weed along with other things to my Tirz. That has lifted my dopamine levels somewhat. I will never quit you, Mary Jane.

CopperSignal27archiveMar 13

I wonder whether this stems from dropping pounds along with reduced food intake and a slower burn rate instead of the medication alone. After staying on it for months and shedding quite a bit, the cause could lie in those changes rather than any direct action from the shot. Doing activities anyway even when motivation feels absent often brings small wins that lift spirits and drive over time. Starting recently with little change so far points more toward the medication itself. Should the flat feeling last beyond several weeks then switching to the other option might make sense. It helps to avoid dwelling too much since expectation can create real sensations especially after learning how these drugs touch reward pathways in the brain. Research overall finds no rise in low mood with this class of treatments so lasting loss of pleasure does not appear common.

PatientSparrow84archiveMar 13

Certain lots from particular sources trigger this for me. I only keep using the batches that don't.

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Advice on dealing w/ anhedonia on Tirz · ZyraTrack Community