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Hair loss prevention options besides finasteride/dutasteride?

29 replies17 peopleJul 17, 2026☆ Follow
Summary

What non-systemic DHT options help with hair thinning from GLP-1 weight loss or other causes?

Users discuss avoiding finasteride and dutasteride due to past side effects and instead try topicals like minoxidil, copper peptides such as GHK-Cu or AHK-Cu, ketoconazole shampoo, and experimental anti-androgens. Experiences vary, with some reporting reduced shedding from nutrition fixes or peptides while others insist only 5AR inhibitors truly stop progression. Several note hair loss from rapid weight loss is often temporary once nutrition stabilizes.

What this discussion establishesWhere people disagree

Whether experimental topicals or peptides can match the effectiveness of 5AR inhibitors, and whether hair loss on GLP-1 drugs requires anti-androgen treatment at all.

Still open

Long-term safety and actual efficacy of KX-826 or similar compounds, plus whether injectable peptides produce consistent regrowth.

Nothing here is advice.

29 replies · 17 people
PlainMarble54archiveopening postJul 17

I'm dealing with some hair thinning that seems tied to fast weight loss on GLP-1 meds and want to avoid anything that affects systemic DHT like finasteride or dutasteride. I saw mentions of a topical androgen receptor antagonist called KX-826. Has anyone tried it or found solid discussions on topical anti-androgens for keeping hair while on these meds? I'm after general experiences or other options that don't touch systemic DHT.

GreyWillow31archiveJul 17

Topical minoxidil plus topical ghk-cu on the scalp would be my first choice if I wanted to skip fina or duta. There are companies that make ghk-cu in a spray you can just apply to your scalp.

QuietSignal61archiveJul 17

You're probably malnourished if a GLP med is making your hair thin. Take a B complex, a trace mineral complex, vitamin D3 with K complex, and magnesium. GHKCu likely cuts shedding by fixing a mild copper deficiency that a trace mineral complex would handle. Two percent ketoconazole shampoo is the mildest effective drug option if you're steering clear of proper 5AR inhibitors.

PlainMarble54archiveJul 17

It might just be me trying to blame the GLP meds. I already had a hair transplant for the front. Now the middle is thinning too and I don't want to go through getting injected a hundred times with adrenaline again. I tried finasteride and it wrecked me for about ten months so I'm never going that route again. I want to keep my DHT levels intact. The substance I mentioned should work for that.

PatientFenwick91archiveJul 17

Those medications that block male hormones can help when hair thins from that specific condition. Did a skin doctor confirm your situation, or are you assuming based on the shedding alone? Shedding happens for many reasons beyond hormones. You mentioned the weight loss drug might be behind it. My own experience was similar at first, with major thinning that eventually reversed completely after I realized it wasn't hormone related. I ran some blood tests to figure out the actual trigger for the loss instead of jumping into those blockers in either form.

QuietSignal61archiveJul 17
↳ replying to @PlainMarble54

Heard you. There's a lot of guesswork in the hair loss community. The truth is 5AR inhibition is the only route that reliably stops balding and helps regrow hair. My two best friends from high school started losing hair before senior year so I've heard plenty about their experiences. One regrew a bald spot with dutasteride and the other went abroad for a transplant. Ketoconazole 2% shampoo is what you want once nutrition is sorted. Minoxidil is unpredictable and hard to recommend. Dutasteride is safer and stronger than finasteride. You need to read up because the half life is measured in weeks and that's how people get into trouble. Try a topical version without propylene glycol to limit systemic absorption and only use 1mg per week. If you want to stop losing hair it's the only medicine that works. You can chase the other stuff but finasteride, dutasteride, ketoconazole, and RU58847 are the only things that actually do anything. Fin and dut are the strongest but hardest to dial in, ketoconazole is the safest approach.

PlainMarble54archiveJul 17

The compound I mentioned is basically RU58847 but supposedly without the risks. The problem is nobody seems to be selling it.

PatientTimber12archiveJul 17

Over the past period I've put on five percent minoxidil morning and night as well as the AHK-Cu serum just in the mornings and now I'm seeing extra hair returning to my scalp.

PlainMarble54archiveJul 17
↳ replying to @PatientTimber12

I wonder if that tool has been effective when you use it.

SlowLedger21archiveJul 17
↳ replying to @PlainMarble54

I spent quite a while digging into information on this and even asked around on the forum to see if others had experimented with it. Everything I came across pointed to some really harsh reactions. Worries about problems with my heart kept me from ever trying to get hold of any.

PatientTimber12archiveJul 17
↳ replying to @PlainMarble54

Can't really tell because I began that treatment simultaneously with the other stuff. I realize one should try new products one at a time to see their separate results, however my eagerness about ending baldness made me skip that and start both together. Luckily it seems harmless anyway.

CopperBeacon88archiveJul 17

I put together a few mixtures using hyaluronic acid for the foundation then stirred plain ghk-cu into one batch and ahk-cu into the second. My spouse dealt with some thinning that was really getting to her. The mixtures look like they halted the issue. It is probably all in her head yet her feeling better makes the effort worthwhile.

LevelTimber64archiveJul 17
↳ replying to @QuietSignal61

Protein seems like the real focus here. Glad biotin never got brought up at all. Haha

BlueThistle79archiveJul 18

After beginning hormone therapy my hair started thinning much faster until the scalp showed clearly from the front all the way back. Scary posts online kept me away from that drug for a while. These days I use one milligram three times weekly plus two and a half milligrams of the other medication by mouth each day and the hair has begun filling in again. The only difference is stronger sex drive with no drawbacks.

SlowBramble67archiveJul 18
↳ replying to @PlainMarble54 (opening post)

I chose to inject the AHK version instead of applying it to the skin and matched the routine used with the GHK one. Following two treatment periods the thinning on my scalp stopped and hair across my body increased in both volume and thickness.

PatientBeacon15archiveJul 18

I've been injecting this copper peptide under my skin for roughly eight weeks without spotting any boost in how quickly my hair comes in. Everyone agrees these treatments demand patience, sometimes stretching out to a full year before anything shows. Research suggests the peptide can encourage follicles to produce more strands, so judging its value now would be premature.

For twelve years straight I've swallowed finasteride every morning and felt zero unwanted effects. Back then it moved my hairline forward to where it sat a year before, and that position has held steady since. At sixty I still see the same front line I had at forty seven. Lately I switched over to dutasteride each day while tapering the first drug, and nothing negative has appeared so far. The newer one blocks an extra enzyme that converts testosterone into the hormone that shrinks follicles.

A couple months back I began dabbing another copper peptide on my scalp but noticed nothing right away and got careless about mixing batches, so I stopped for a bit. I'll probably start again since I never gave it a fair shot. Around the same time I tried a research compound on my skin and again saw little change, though I know it lacks solid safety data and I watch for any chest discomfort. A few people online report strong results while most do not.

Plain minoxidil lotion never moved the needle for me, yet lately I've mixed it with a retinoid that improves absorption and boosts the enzyme needed to activate the lotion. Some users respond well because they already make plenty of that enzyme naturally, but I suspect I'm not one of them. It's still too soon to know if the pair will help.

Looking back, this whole effort actually began fifteen years ago when I figured nothing would work. Then I read a stray remark that the retinoid might shield hair on its own, and I already owned a tube. Using just that product seemed to thicken things a little before I added anything else, possibly because it affects the same enzyme.

More recently I started taking minoxidil by mouth, though again any payoff remains hidden. Its main action is widening blood vessels around the roots so they stay healthier and might even spark fresh growth. Whatever new strands appear should stay longer thanks to the enzyme blockers keeping the harmful hormone in check. That pairing is what most doctors hand out.

Rolling a needle across the scalp can also help by letting liquids sink deeper, yet going too far or too often sparks swelling that works against follicles. Still, mild irritation might trigger a protective response that grows hair, as seen in an old report of someone whose burned scalp later sprouted new strands. I'm curious what the next twelve months will bring, even if I end up with no clue which step actually mattered.

SteadyQuill55archiveJul 18

I really wanted to avoid topical minoxidil because of my cats and not wanting product in my hair. But I was pleasantly surprised that the generic minoxidil foam became my personal holy grail. Every day after the shower I grab it from under the counter, spray a small amount onto my hand over the sink so nothing hits the floor, then put it right back. I walk over to the tub, flip my head down, rub my hands together, massage it into the front where I noticed thinning, then distribute the rest over my whole scalp and massage for a minute or two. Then I wash my hands well. I let it air dry and comb it. My hair looks great, the product lifts the roots without weighing anything down. Even if I found out tomorrow it does nothing for regrowth I'd still want to keep using it.

GreenHarbour22archiveJul 23
↳ replying to @PatientBeacon15

Can you take klow with Terz? My wife is forty-six and I think this would help her a lot.

PatientBeacon15archiveJul 23
↳ replying to @GreenHarbour22

It works well enough in my experience. I've kept this up for quite a while already.

PlainMarble54archiveJul 23

I don't think finasteride or dutasteride is the real solution to hair loss itself. To me it's just a band-aid for something more complex. If DHT alone caused hair loss then someone like Dolph Lundgren in his prime should be extremely bald and any sedentary person who stays indoors should have perfect hair, but reality shows otherwise. He has all his hair even now. Look at programmers or IT guys in general, many are bald. It makes you wonder. I'm still researching but I'll handle the hair loss without touching DHT levels.

PlainAlder11archiveAug 13
↳ replying to @SteadyQuill55

Curious how everything turned out with that. My spouse had already started dealing with thinning hair long before beginning that treatment. I had looked into a couple of those options.

SteadyMeadow73archiveAug 13

Hair loss happens for lots of different causes. My mother deals with an autoimmune condition that caused baldness from her teenage years onward, yet she experienced significant regrowth during each pregnancy. Most female relatives experience thinning around the time of periods or menopause. Relatives with that hormonal disorder also known as PMOS notice thinning specifically on the crown, and hormones seem responsible. I've looked into hormone replacement therapy for stopping hair thinning, and while research indicated some positive changes in women's hair, the actual measurement methods didn't pick up on it. It appears hormone replacement offers limited benefits, whereas treatments that block DHT lead to actual regrowth. Celebrities aren't reliable examples for how well those DHT blockers work, since their routines involve unknown products plus they can afford multiple options. I should check with my daughter about results from the solution I prepared for her. She mentioned the copper peptide version I created for her skin had faded her acne marks, and she felt pleased about it.

WryWillow91archiveAug 13

Hair shedding occurs in females as well from these injections owing to lower calorie and nutrient consumption. So those drugs like finasteride and dutasteride are unlikely to do much good unless male pattern baldness is also happening. I paid attention to the options that were suggested such as minoxidil and the shampoo containing ketoconazole. After finishing the weight reduction the hair returns to normal since this shedding is not permanent unlike male pattern baldness.

PlainAlder11archiveAug 14
↳ replying to @SlowBramble67

Hi, I'm hoping for extra details about this item. It's intended for my partner who's dealt with hair thinning over the past few years. I've only just begun checking into things like sources and quantity guidelines. Several spots where I order my usual compound also carry this in assorted volumes.

SlowBramble67archiveAug 14
↳ replying to @PlainAlder11

Bought fifty milligram vials per set. Did not see changes when using it as a serum. She recommended injecting it. I have injected one milligram a day directly under my scalp skin with small insulin syringes. But I don't think injecting under the scalp is necessary. It improved hair growth and thickening overall. I also saw some new follicles on my head. I had a hair transplant and the clinic says new follicle growth can continue for a year so I can't be sure if the peptide caused any new follicles. It definitely improves hair quality. I stopped after two cycles and haven't seen hair loss since. Next cycle I'll use GHK-Cu instead hoping it helps some loose skin at my belly. Nothing visible when standing but some when sitting. I don't know if that's related. Before the end of the second cycle and after I got more white hair on my chest and scalp in a short time, not a lot but noticeable. I call it two cycles but it was one cycle with two vials used one after the other.

PlainAlder11archiveAug 14
↳ replying to @SlowBramble67

I'm confused by that reply. Earlier I mentioned wanting info on that copper peptide. Appreciate the help. Does the shot have to go right into the head area, or is the stomach fine the way we handle everything else?

SlowBramble67archiveAug 14
↳ replying to @PlainAlder11

Turns out the compound is AHK-Cu instead. Earlier I slipped up and put the wrong label in two spots so I just fixed those. My mistake there. Since three in the morning until three this afternoon I stayed on the road nonstop and it wore me out. Now I need to head back for another two and a half hours. The last four days each meant fifteen hours behind the wheel with no choice because the company belongs to me. This note went out during a two hour pause. The midsection feels fine too since the scalp shots brought gains all around so the belly should match. Instructions were to handle it exactly like GHK-Cu under the matching protocol. The scalp spot came from my own digging with a laugh.

SteadyCinder62archiveAug 14

The tressless community on reddit has a lot of information on this subject.

SlowBramble67archiveAug 14
↳ replying to @SteadyCinder62

I appreciate the suggestions you gave, it's helpful stuff. Check out the images underneath. The initial photo dates back to last year, roughly thirty days prior to my procedure. Clearly visible there is how sparse my hair was. Following the operation, the density increased noticeably. However, it stayed quite fine up until about three and a half months back. The latest shot was captured just moments ago.

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