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Looking for weight loss brakes!!

43 replies24 peopleJul 20, 2026☆ Follow
Summary

How can someone on low-dose tirzepatide after duodenal switch surgery slow ongoing weight loss without stopping the medication entirely?

The thread shows that continued loss at 2.5 mg tirzepatide is common after major prior weight reduction and bariatric surgery with malabsorption. Participants report success by lowering the weekly amount further, splitting doses, or extending intervals between injections to 10-14 days while increasing calorie-dense food choices. The original surgery limits how much extra food can be absorbed, so dose reduction is viewed as the main lever. Several people describe similar experiences and plan to keep titrating down rather than quit.

What this discussion establishesStill open

Whether any dose exists that fully halts loss for every individual in this situation

Nothing here is advice.

43 replies · 24 people
WarmWillow50archiveopening postJul 20

I'm dropping weight faster than I want and it isn't leveling off. It sounds like a nice issue but at my age looking too thin isn't appealing and I'm heading there quickly. I'm 5'6 and 134 pounds yet carrying 8-10 pounds of loose skin on my midsection so my actual weight sits in the low 120s according to my doctor. I dropped from size 24 down to 4 and now some 2s fit. There aren't many of those sizes around and I worry I'll look unhealthy if this keeps going. Another 10 pounds would put me under a healthy BMI. Stopping the medication scares me so I've already reduced to 2.5 mg of tirzepatide yet the loss continues. The drug kills my hunger but the duodenal switch surgery from 2021 also leaves me absorbing only part of what I eat. Roughly 1500 calories with plenty of protein might give me just 950-1200 usable calories.

CopperSignal27archiveJul 20

The amount of food you describe is lower than what most expect for weight maintenance yet after years of big losses the calories needed to hold steady can drop a lot. Whether adding more food helps depends on absorption. If extra intake won't increase absorbed calories then the fix involves choosing foods that the body takes up more readily. If more food does help then the next step is reducing the tirzepatide amount until eating increases or weight stops falling even if that means going below 2.5 mg. This situation is easier to manage than the opposite problem of stalling at a higher weight.

WarmMeadow92archiveJul 20
↳ replying to @WarmWillow50 (opening post)

Instead of quitting could you stretch the time between doses? Stopping the medication worries me as well. You might also try going lower than 2.5 mg since nothing requires that to be the smallest amount used.

PatientBeacon15archiveJul 20

I would suggest lowering the dose and adding a quart of ice cream daily.

IronBramble31archiveJul 20

If the pen is the single-use type you could transfer it into a sterile vial and draw half the amount to test for the week. I tried something similar with another medication but it felt too strong so I moved on. Another option some try is adding a different compound though results vary.

LevelThistle44archiveJul 20

Reducing the amount or increasing the gap between doses is what others have suggested and it seems simpler than the reverse problem of trying to lose more.

WarmWillow50archiveJul 20
↳ replying to @CopperSignal27

That approach sounds workable so I'm going to try it. The pens I was given are single-use so I'll move the contents into sterile vials. I'd rather handle this situation than the opposite one even though it's unexpected.

PlainAlder11archiveJul 20

I'm dealing with something similar though not quite as extreme. I reached my second goal and beyond while on retatrutide at 9 mg and recently dropped to 6 mg. I still have the loose abdominal skin and plan to keep lowering the dose based on the scale. I was surprised to see skin remain after losing only a couple pounds a week.

IronKettle95archiveJul 20

You could also keep the same amount but change how often you inject such as every ten days or every other week.

RustBeacon82archiveJul 20

I'm in the same spot still losing at 2.5 mg. Next time I'll try 2 mg and if that doesn't work I'll start spacing the doses. I have some retatrutide but it raised my heart rate so I'm sticking with tirzepatide since I have a supply and want to avoid going back to constant hunger.

GreySparrow64archiveJul 20

Have you considered a carnivore approach with meat eggs and fat since those foods are nutrient dense and don't raise insulin much. The goal is to keep weight from muscle and bone rather than just any scale drop.

RustKettle57archiveJul 20

If 2.5 mg already cuts appetite sharply then going down to 2 mg or even 1 mg makes sense so you can eat more. Switching compounds is another idea some consider because hunger suppression can be milder yet I wouldn't worry about going lower on the current medication just to allow more calories.

SlowAnchor19archiveJul 20

Spacing shots to every 10-14 days is worth trying while you arrange lower doses. Also look at grocery habits and switch to full-fat versions of things you already buy such as yogurt chicken thighs or ribeye instead of leaner cuts. Adding butter cheese or nuts can help too.

WarmWillow50archiveJul 23
↳ replying to @GreySparrow64

I tried the carnivore way earlier but couldn't stay with it long. Forcing protein intake is hard since I'm not a big meat eater and I gave up after two weeks.

WarmWillow50archiveJul 23
↳ replying to @SlowAnchor19

Thanks for the suggestions. I already choose full-fat items because I absorb very little fat but too much at once can cause digestive issues. Still the idea of using darker meat cuts is helpful.

SlowAnchor19archiveJul 24
↳ replying to @WarmWillow50

I think I understand the digestive side effects you mean. Hope you find a way to slow things down.

RustKettle37archiveJul 25

I felt better overall on retatrutide except for low motivation and steadier blood sugar. I also went too low on weight even at 1 mg twice weekly and had to stop for a while to avoid losing more muscle. Micro-dosing or weekly shots still caused loss so now I'm trying other compounds to maintain instead.

LevelAlder29archiveJul 25

No new ideas beyond what others mentioned. Tiny amounts like 0.25-0.5 mg have been discussed by some. Spacing the dose also seems practical. On another note it's encouraging to hear someone who lost 200 pounds now fits into size 4s.

SlowLedger21archiveJul 25

I agree with lowering the dose. I'm currently at 1 mg per week split into two 0.5 mg shots and can eat normally while keeping weight steady.

GreyFenwick31archiveJul 26

No fresh advice beyond the dose reductions already suggested. Dropping to 1.5 mg or stretching the interval between shots could help along with plenty of protein. It's inspiring to see such a large loss and reaching small sizes and I'm glad the earlier information helped ease some concerns.

WarmWillow50archiveSep 7

Still losing with no sign of it stopping yet, though the pace has slowed. I'm at 128 pounds now and the doctor said to hold there, but it's proving tough. I've lowered the amount again and now space the shots every 10 days, hoping that finally works. Never expected this when I began. It's not the worst issue compared to what others deal with, but it's annoying. Even I can see I'm thin now, unlike before when my mind couldn't register the change. Looking in the mirror it's like seeing a stranger who's skinny. Thin is okay, just don't want to go too far and end up looking skeletal, and I'm close to that line.

WarmMeadow92archiveSep 7
↳ replying to @WarmWillow50

That plan makes sense. You could try stretching the time between shots even more to check if hunger comes back. Wondering if there's a mental side to it too, since these meds can make it simple to eat very little, which might hit hard for someone who tends that way. Maybe chat with a professional to check. Also curious about your test results, as ongoing loss might point to something like an overactive thyroid that should be ruled out. Hope you reach a stable point soon.

GreyFenwick31archiveSep 7
↳ replying to @WarmWillow50

Hope things settle soon. What about trying some calorie-packed drinks, like a protein one mixed with sugary fruit, full-fat yogurt, avocado, or nut butter?

BrightMeadow15archiveSep 7

Exactly, and not only for the taste. My suggestion here is that cream on berries is really good, especially now. You mentioned absorption issues after surgery, and some vitamins need fat to work well, like A, D, E, and K. Lots of people lack D already, and these meds can add to that. So for better nutrition overall. Second thought, if full cream feels like too much mentally or by texture, start in the middle with half-and-half in coffee or on fruit. Regular cream won't thicken as much as the heavy kind. Wishing you well.

BrightMeadow15archiveSep 7
↳ replying to @WarmMeadow92

New to this area, but if someone is on thyroid treatment the amount often changes with weight, and a good doctor checks labs closely. Thyroid affects everything. Added note: at this age, resistance work matters a lot to keep muscle. Bodyweight moves work fine without a gym.

WarmMeadow92archiveSep 7
↳ replying to @BrightMeadow15

Bodies are complicated and hormones might play a role in the ongoing loss. For instance, if on thyroid medication the dose could need adjusting after big weight changes. Sounds like not enough fuel, but still worth checking other causes and the mental side. Watching certain shows made me see how some of my own past weight issues tied to mental health. The mind can be the strongest factor.

WarmMeadow92archiveSep 7
↳ replying to @GreyFenwick31

Liquid calories are a solid idea, especially after surgeries that limit stomach size. I had that procedure years ago and still can't eat large amounts at once, but drinks go down fine without trouble.

RustBeacon82archiveSep 7

I've stayed at the same weight for nearly two months now. Lowered to a smaller weekly amount and switched to regular higher-calorie foods. It seems to be working while still quieting the food thoughts with the small dose. Keep nuts around for when the urge hits.

LevelAlder29archiveSep 7
↳ replying to @WarmMeadow92

I'm good at making a high-fat smoothie loaded with calories using things like MCT oil, hemp seeds, creamed coconut, and nut butters for easy extra intake. Could swap in ice cream for the usual base too. Hope it helps.

QuietCinder50archiveSep 7

Mass gainer powders might work, the kind used for adding size along with nutrients.

BlueTimber11archiveSep 7
↳ replying to @WarmWillow50

Not sure if it came up, but besides the shots what else are you doing? Strength training in particular? It helps long-term health and metabolism. Holding onto muscle while in a deficit is tough and really needs a solid program.

CopperSignal27archiveSep 8

Still unclear how much is from the surgery limiting absorption no matter the calories versus simply not taking in enough. If it's mainly low intake it would seem straightforward to pause the med until weight starts coming back, and I don't get why stay on it at a reduced level if that's the case. Understand the worry about appetite or weight jumping back, but sometimes you have to. If calories are enough but absorption is blocked from the surgery plus long-term low intake effects, then expert help is needed since most doctors won't know how to handle it.

PlainQuill85archiveSep 8

Not a doctor, just sharing what I've read in medical papers. The triple agonist version adds a metabolism boost, so it could be worth trying.

QuietPebble46archiveSep 8

Track intake and eat above what you burn, that's the basic rule. To gain, reduce the dose so more food is possible.

IronBramble31archiveSep 8

I probably relate more than most since my family has lost hundreds of pounds total with similar surgeries and then using this med to drop and hold weight. Finding the right small amount is key, but maybe a full break from it for a while is needed. It sucks to think about the scale moving or clothes changing, but we've all had to pause for procedures and then restart, often with some regain after. Rinse and repeat with multiple stops this year. Last shot was over a week ago and now eyeing cookies at the store, with weight swinging by over twenty pounds.

RustBeacon82archiveSep 8

Managed to stay steady within a couple pounds the last couple months. Switched to regular instead of low-fat versions of foods and dropped to a 1.5 mg weekly amount that keeps the thoughts quiet without overdoing it. Hoping it holds.

GreyFenwick31archiveSep 8
↳ replying to @RustBeacon82

Nice! Sounds like you've reached your target.

RustBeacon82archiveSep 10
↳ replying to @GreyFenwick31

Thanks. I did reach goal, actually a bit under so there'd be room to move while figuring out maintenance. Now if the body image issues in my head would settle.

GreyFenwick31archiveSep 10
↳ replying to @RustBeacon82

That's the slowest part to adjust. I've lost before and the extra skin really messes with how the mind sees things. Then adding a few pounds back makes me think it looks better.

PatientHarbour28archiveSep 10
↳ replying to @RustBeacon82

What others see when looking at you versus what you see in the mirror. Wish there was a simple fix for that part.

AmberBeacon57archiveSep 10

Spacing shots sounds good too, maybe every 10 days or two weeks. That's one approach some are testing for maintenance.

RustKettle37archiveSep 10

Similar spot where I passed my early targets but don't want to quit entirely because it fixes long-standing insulin issues. Now on a small split dose twice a week. Higher amounts suppressed too much and that's how the loss happened, but then I paused for a month when it went too far. Restarting didn't hit as strong, so the current low amount lets me eat, quiets the thoughts without killing appetite, and avoids the flat feeling. Allows normal things like coffee or carbs without the crash. It's about finding the balance. Since restarting makes it milder, maybe do that on purpose to let weight recover a bit with training, then go back to a tiny maintenance level.

PatientHarbour28archiveSep 10

Folks often overlook how the drug levels balance out over time. With a seven-day half life it takes about five weeks at a steady amount to reach equilibrium. The math shows it builds gradually until each week starts with roughly the prior dose still in the system, adds the new one, and clears the same total. Once there, it stays consistent. Random note about restarting feeling weaker makes sense because of this. Same thing happens in reverse when lowering the dose.

PatientAlder89archiveSep 10

If you prefer the pen you can add it there instead of a vial. Hope the right amount turns up.

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