CommunitySide Effects

Chilly Side Effects

21 replies18 peopleAug 9, 2026☆ Follow
Summary

Do tirzepatide or retatrutide cause increased cold sensitivity?

Multiple users report feeling colder overall and more tolerant of heat after starting these medications. The effect appears tied to both the drug and the resulting calorie deficit or fat loss, with some noticing it before major weight change and others mainly during active loss. It often allows higher AC settings and reduces complaints about indoor chill, though a few still feel cold even in maintenance.

What this discussion establishesWhere people disagree

Whether the temperature shift comes mainly from the medication itself or simply from reduced body fat and lower energy expenditure

Still open

Why the cold feeling resolves for some in maintenance but continues for others

Nothing here is advice.

21 replies · 18 people
PlainBeacon63archiveopening postAug 9

While browsing the forum I saw other threads mention temperature shifts and realized I had noticed the same thing, wondering if it was just me. Normally I stay warm, but after more than a year on Mounjaro I started feeling chilly more easily. When insurance paused it for four months I went back to running hot, yet restarting Tirzepatide brought the cooling back. This actually helps at home because my wife is always cold, so we can now keep the AC at 79 instead of 78 without me overheating or her needing a blanket as often.

IronFenwick84archiveAug 9

I used to stay warm but now feel the cold more. Not sure if Tirz is responsible or if losing the insulating fat layer explains it.

SteadyAnchor13archiveAug 9

Since beginning Tirzepatide I have felt colder than ever before. Winter worries me because I already get chilled when temperatures stay above 80.

IronLantern24archiveAug 9
↳ replying to @PlainBeacon63 (opening post)

I felt the same way until switching to reta. Now I finally understand why kids wear hoodies in 80-degree weather.

ClearLantern70archiveAug 9

Now that you mention it, yes. I normally overheat and struggle exercising in the sun, but lately it has become much easier to handle the heat.

LevelLedger10archiveAug 9

For me the chill started with the last 15 pounds lost. Even though it is August in the south and definitely not cold, I still reach for a blanket in the mornings and evenings. It feels metabolic, tied to overall energy balance, yet it remains strange.

IronPebble76archiveAug 9

Yes, this comes up a lot. I cannot tolerate cold air anymore, but being outside at 90 degrees feels comfortable, so there is an upside.

GreenMarble65archiveAug 9

Same here. After starting reta in March the summer heat in Bama felt less intense. I do not get cold indoors, but stepping outside in the heat makes me notice how well the air conditioning works.

PlainAlder11archiveAug 9
↳ replying to @PlainBeacon63

This one functions the same way and began in April with six milligrams. But the things give off a smell like animals because of the sweat inside them. My fourteen year old grandson says that is the style.

LevelBeacon74archiveAug 9

Weight loss and metabolic shifts seem to be the cause. The more I lose, the colder I become.

PlainBeacon63archiveAug 9
↳ replying to @LevelBeacon74

When I restarted Tirzepatide I noticed the temperature difference before any weight came off.

KeenPebble54archiveAug 10

Reta has me freezing. It is 100 degrees outside yet I keep turning the AC off. I thought the thermostat was broken until I realized it was just me, but I am not upset about the lower energy bill. Less spent on utilities means more for peptides.

SharpFenwick16archiveAug 10

I think being in a caloric deficit makes the body conserve heat, so you feel colder. Or once you reach maintenance the reduced insulation plays a role.

SlowBramble67archiveAug 10

That came up for me throughout the opening three months on Tirz.

SlowBramble67archiveAug 10
↳ replying to @SharpFenwick16

This loss didn't come up in my upkeep period. The drop in pounds wasn't major then either. I got used to things without trouble.

SharpFenwick16archiveAug 10

Even with things holding steady the chill hasn't left me. It's milder now than during the earlier reduction stage.

KeenWillow77archiveAug 10

The cold feeling turned into a problem for me right after moving up to the current dose level, where I have stayed since. I've been on this for roughly two months altogether, holding steady at that amount through my last four injections, yet the chills only showed up in the past couple of weeks.

QuietMarble25archiveAug 10

Absolutely, my fingers and toes become extremely chilly. The symptom felt more severe during the opening weeks on reta, yet these days it appears mostly right after an injection.

GreyLedger65archiveAug 10

I felt chilly throughout the period when I was dropping pounds. That's just how it goes, apparently. So I bought heated footwear and a cozy top, and basically wore those nonstop for quite a while. After half a year in the keeping-it-off stage, that chilliness went away. Interestingly, I handle warm conditions better now compared to back when I carried an extra fifty-five pounds.

IronHarbour22archiveAug 11
↳ replying to @LevelLedger10

Just checking in from SC. Got a golf round lined up tomorrow with the heat index hitting 105. For me the real driver is running a big drop in daily calories, whether on that med or not. All day long I stay chilled while indoors at the job or anywhere else. These days the place stays set around 75 or 76.

CopperSignal27archiveAug 11

After shedding quite a bit of body mass ahead of starting those medications, I handled warmth more easily while feeling chillier in general. Part of it came from having less fat to hold in heat, plus my overall calorie burn falling enough that my system skipped shivering no matter the chill. Adding the pair of compounds made cold stand out more, above all on my lower arms, where even modest temperature shifts intensified strange skin feelings and made me reach for longer sleeves.

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Chilly Side Effects · ZyraTrack Community