CommunityDosing & Titration

Tirzepatide at higher dose?

9 replies9 peopleJun 19, 2026☆ Follow
Summary

What are the pros cons and evidence for using tirzepatide weekly at 20mg or 25mg?

Users discuss higher doses mainly when weight loss stalls after a year or more on 15mg or when hunger returns. Limited data from semaglutide trials at elevated doses showed modest extra loss but more side effects without new severe risks. Manufacturer trials on 20-25mg tirzepatide are underway but unpublished. Some report continued loss at 20mg while others see no benefit and note increased nausea or other GI issues.

What this discussion establishesWhere people disagree

Whether increasing beyond 15mg is reasonable depends on obesity severity prior response to dose increases and tolerance of unknown added risks versus switching compounds

Still open

Actual safety profile and efficacy results from the ongoing manufacturer trials on 20-25mg doses

Nothing here is advice.

9 replies · 9 people
GreyMarble68archiveopening postJun 19

Hey everyone experimenting out there, curious about the benefits versus drawbacks from using twenty or twenty five milligrams each week of that compound? Come across any research covering those levels?

ClearBeacon24archiveJun 19
↳ replying to @GreyMarble68 (opening post)

I saw another user here mention taking twenty-five milligrams. A search might bring up that thread.

SlowAnchor19archiveJun 19
↳ replying to @GreyMarble68 (opening post)

Been checking for the same thing myself and heard about someone trying that amount yet no published reports have shown up anywhere.

AmberCinder18archiveJun 19

From what I gather, research appears to be underway at the moment on those 20 and 25 milligram levels, yet I have not encountered any published findings or even clues in any sources I've checked.

WarmHarbour28archiveJun 19

Yeah it matches the full twenty milligram level even at nineteen point five. My weight hasn't budged at all after the tenth of May in twenty twenty six. Though I still overeat and I realize that. So what does this reveal? I've shed sixty pounds overall.

GreyAlder39archiveJun 19

Came across some numbers about overdoses from these weight loss shots showing up in hospital emergency rooms across the country. Roughly eighteen thousand incidents occurred last year from what I recall. Quite a few involved people injecting the full device at once rather than splitting the doses. This led to intestinal obstructions, issues with the gallbladder, and similar complications. A handful ended up with ongoing problems afterward, the kind that either finish you off or mess with your head permanently. I can speak from experience there, though the whole thing was half in jest.
People ramp up amounts mainly because results feel absent or too slow to arrive. When nothing happens at all the straightforward move is trying a different approach altogether. For me the initial option fell short so I paired it with another compound and found the two worked nicely alongside each other. The rush for quicker change often stems from restlessness or constant hunger pangs. That emptiness usually points back to some deeper habit or emotional gap worth examining. One method that helped me involved jotting down a few things each night that went well or came my way during the day. After a couple of weeks the habit started shifting how I felt and it cost far less than professional counseling. No sense in dwelling on every misstep either.

CopperSignal27archiveJun 19

If the plateau is genuine and shows up well after the first year on treatment or the scale barely moves while appetite remains tough to handle then looking at other approaches seems sensible. Severity of the starting weight problem probably influences the choice yet only a really big issue would normally call for extra steps when the usual maximum amount fell short. The situation has to be serious enough to accept the unknowns tied to larger amounts or combinations. Trials with higher levels of the related medication produced some further loss but nothing dramatic and they brought more unwanted effects though nothing entirely new or alarming appeared. That offers a bit of reassurance about trying more here. Whether moving higher still makes sense probably turns on how the last step felt if that change helped without major trouble then another increase could be worth considering. Otherwise introducing one of the additional compounds at small starting levels with slow steps upward could be another route. One option costs less while the newer one has less background but may deliver better results with fewer issues when kept modest though larger amounts of it lead to stomach upset and tiredness in roughly half the users still not quite as often as the first alternative at big levels.

AmberCompass48archiveJun 19

Whoa, going five milligrams past my usual reta amount left me dealing with nonstop diarrhea across two full days.

WarmHarbour28archiveJun 20
↳ replying to @GreyMarble68 (opening post)

My eating isn't way over normal, only a little extra. I've adapted to this ongoing queasiness. The image beside me shows how things really are. I'm stubborn like that. Not at all like someone chasing big muscles. A layer of fat gives me cushioning and better resistance. These days I move with more ease and quickness, which fits me fine. Getting on in years means lighter loads help, yet I still have to manage falls and rolls. My usual activities keep me active enough without added strength work. Baling time draws near.

WarmMeadow92archiveJun 20
↳ replying to @GreyMarble68 (opening post)

Taking the twenty milligram strength of the medication. People have talked about the maker trying out even bigger amounts, though nobody knows the exact levels yet and I doubt they match the guesses floating around. We'll find out eventually. The drawbacks that come to mind are others in the discussion group viewing you as odd, plus these little points on my forehead that catch when I pull a top over my head. On the upside the pounds are still dropping after a year and a half.

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