CommunityConditions & Comorbidities

Bariatric surgery, malabsorption and GLPs

18 replies9 peopleMay 9, 2026☆ Follow
Summary

How do post-bariatric surgery patients handle GLP-1/GIP medications like tirzepatide and retatrutide for ongoing weight management?

People who had procedures such as duodenal switch or sleeve gastrectomy report extreme sensitivity to tirzepatide, often experiencing appetite shutdown even at low doses combined with reduced calorie absorption. Several are experimenting with lowering tirzepatide while adding retatrutide in hopes of allowing enough food intake for maintenance without further rapid loss. Vitamin supplementation remains essential due to malabsorption risks, and bloodwork is used to monitor outcomes. Experiences vary widely with no established protocols for switching or stacking in this population.

What this discussion establishesWhere people disagree

Whether to switch to retatrutide near goal or simply reduce tirzepatide dose for maintenance

Still open

What dosing ratios or final maintenance levels work best after bariatric surgery

Nothing here is advice.

18 replies · 9 people
WarmWillow50archiveopening postMay 9

I got to 320 pounds and booked weight loss surgery back in 2020. The pandemic pushed everything back, so the procedure happened the following year. It was the full duodenal switch, which took out most of my stomach and rearranged my intestines so only about 150 centimeters of small bowel remained. Normal length runs six to seven hundred centimeters, so I now deal with lifelong malabsorption that needs daily supplements.

A medication like Tirz works almost too strongly in my situation. Between the smaller stomach and the reduced absorption, hitting even twelve hundred calories feels tough, and I probably take in only two thirds of what I eat even when the choices are solid. The pounds have been dropping fast, which is fine, but I do not want to keep losing at this pace and end up looking gaunt.

I have started lowering the Tirz dose from its highest point of five milligrams while adding Reta. Right now I am at four milligrams of Tirz plus one milligram of Reta. Next month the plan is three milligrams of Tirz and one and a half of Reta. I am actually looking forward to some return of hunger signals so I can manage several small meals instead of struggling to eat enough.

I have gone from two twenty three on the first of December down to one fifty five, with maybe five or ten more pounds to reach my goal. That is roughly seventy pounds in five months with no plateaus. My husband pointed out this morning that I am starting to look thin, and it has been eighteen years since he last saw me at this size. I stay busy but do not lift weights yet; once riding season ends I may add the gym in the fall. Have any other people who had the same surgery figured out how to handle this?

WarmMeadow92archiveMay 9

You had surgery right when guidelines were shifting toward SADI-S for very heavy patients instead of the more aggressive BPD/DS, which is rarely done now, only about two percent of cases. My own bypass was years earlier and my starting BMI was probably higher. I have not seen the same rapid drop on tirzepatide that you describe. Finding someone with the exact same surgery may be unnecessary; what matters more is how others have managed fast loss on tirzepatide by adjusting doses and adding retatrutide.

CopperHarbour60archiveMay 9

I had a sleeve instead, done before these medications existed. I take reta because of type 1 diabetes and ongoing weight gain. It does not quiet food thoughts as strongly as tirz but both help with loss. Many switch from tirz to reta without a set plan and simply adjust until they find a workable level. Once switched, most need a moderate dose rather than a very low one. Walking and daily activity help, though I worry about muscle loss too.

WarmWillow50archiveMay 9
↳ replying to @WarmMeadow92

You are right that I cannot be certain whether the strong response comes from the surgery or from being unusually sensitive to Tirz, though I think both play a part. Adding Reta so far has not caused problems. I will keep the current doses for a few more weeks then move to a lower Tirz amount with a bit more Reta.

WarmWillow50archiveMay 9
↳ replying to @CopperHarbour60

I am very close to maintenance and hope Reta will let me stay there without dropping more weight. It will be interesting to see what final dose of Reta I settle on.

IronBramble31archiveMay 9
↳ replying to @WarmWillow50 (opening post)

I understand completely. I had a sleeve years ago and my mother had the DS, so I know the procedure. She tried Tirz for a while and lost some weight, but side effects increased at higher doses and she stopped when coverage ended. She has kept the loss so far and may try an oral option later. For myself I have been testing low doses of both medications together and found small amounts sufficient for holding weight. After recent surgery I am slowly returning to strength work while watching the scale creep back up during stressful weeks.

WarmWillow50archiveMay 10
↳ replying to @LevelThistle44

Tirz shuts my appetite down completely, even at the lowest dose. I am hoping Reta will allow a little more hunger so I can eat enough while still keeping portions reasonable. That is the idea, though my body will decide if it works or if I should just use very small amounts of Tirz instead.

WarmMeadow92archiveMay 10
↳ replying to @WarmWillow50

You are likely both sensitive to the medication and still dealing with reduced absorption from the surgery. There is almost no published data on these drugs after bariatric procedures, so everyone is figuring it out individually. Since you are already near goal, it might be simpler to reach that point first and experiment afterward rather than change now.

WarmWillow50archiveMay 10
↳ replying to @WarmMeadow92

That matches how I am thinking. I will stay at the present doses while loss continues and expect to reach goal in the next month or two. I rarely think about the surgery except for the supplement routine. I once ended up in the hospital with a thiamine deficiency issue and now make sure I take that nutrient regularly.

GreenLedger31archiveMay 26

I had a vertical sleeve years ago. Be careful because results can fade if habits slip. Keep up with vitamins, focus on protein, and eat cleanly to avoid regaining a lot of weight.

LevelTimber64archiveMay 26

My surgery only comes to mind when planning meals to hit protein and other needs. I prefer regular food over processed high-protein items. A standard multivitamin works better for me than the specialized bariatric versions, which caused nausea.

PatientHarbour23archiveMay 26

I had a sleeve several years ago. The quieting effect on tirz is welcome, but for maintenance I would probably just lower the tirz dose rather than switch medications, since the new one may drive further loss instead of holding steady.

WarmWillow50archiveMay 26
↳ replying to @LevelTimber64

I used one multivitamin for a long time but recently changed to another and feel fine so far. The issue with any vitamin is that problems can take time to show up. My recent bloodwork looks good. I have lowered Tirz to 4 mg and am splitting the doses.

PatientHarbour23archiveMay 26

The iron in many formulas can be the troublesome part. I take mine with food and have settled on a bariatric brand that includes a probiotic. I also like their calcium options.

LevelTimber64archiveMay 26
↳ replying to @WarmWillow50

Those chewable vitamins have an unpleasant texture. I may ask my care team what they recommend years after surgery. Glad your labs are solid. Mine are too. Let us know how the lower Tirz dose works. I am considering a higher dose myself to finish the last bit of loss, which has been very slow.

WarmWillow50archiveMay 26
↳ replying to @LevelTimber64

The texture is off-putting. What were you using before Tirz? Those final pounds are always the hardest. My appetite has not returned yet at the reduced Tirz level. I will lower it again soon. It is inconvenient because I receive the medication in single-dose pens that must be transferred to a vial for splitting, but at least insurance covers it fully.

LevelTimber64archiveMay 26

I used another medication first and did well until coverage stopped. After a period of lower dosing I switched and began Tirz. Early progress was modest until I added a small amount of another agent. A study later supported higher doses of that agent, but I had already committed to Tirz. I have accumulated extra supply and a relative is doing something similar before retirement.

PatientTimber12archiveMay 26

I also had a sleeve some years ago. After life changes the weight returned and I recently started tirz to reduce food thoughts while adding exercise to protect muscle. I am earlier in the process so I do not have much personal data yet, but I am interested in what works for others in our situation. For daily supplements I use a multivitamin plus fish oil combination that is easy to take and reasonably priced.

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