CommunityDosing & Titration

Does tirz really have an effectiveness window and should I try to dose up?

57 replies15 peopleMay 4, 2026☆ Follow
57 replies · 15 people · page 2 of 2
BlueAlder28archiveMay 8
↳ replying to @LevelThistle44

That would never work for me. Volume has to be 10 or 12, never 11. Odd numbers are out, though I can set cruise control to 73 or 77. I have quirks.

LevelThistle44archiveMay 8
↳ replying to @BlueAlder28

The easy fix is to reconstitute so 11 mg lands on an even 10 or 20 units. That has to feel better than 12.

BlueAlder28archiveMay 8
↳ replying to @LevelThistle44

Brilliant. You think like someone with the same quirks. That could actually work. People do not realize OCD shows up in odd ways, but it does.

CopperSignal27archiveMay 9
↳ replying to @BlueAlder28

Another person who gets worse tinnitus from tirz. It is one of the stranger sides. I also get the skin sensitivity. It appeared when I raised tirz to 15 mg and became more noticeable when I added reta at 5 mg. Any further small increase in either makes it annoying. Some people say the sensation fades with time, so past intolerance does not guarantee future problems. At least you are close to goal when these limits appear.

LevelFenwick49archiveMay 9
↳ replying to @ClearLedger54 (opening post)

I am in a similar spot. I have been on very low-dose tirz for 15 weeks because I was worried about sides. Started at 0.5 mg and titrated slowly, now at 1.5 mg weekly. I have lost about 35 lb or 12 %, but still have 40–50 lb to go. I wonder if starting higher would have been better or if I have limited my total possible loss. I feel the same uncertainty but have no advice to offer.

SharpLantern61archiveMay 9
↳ replying to @ClearLedger54 (opening post)

The standard schedule is 2.5 mg for four weeks, then 5 mg, 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg until goal. Some people stay on lower doses and never need to move up. I personally stayed at or below 10 mg until the last 10 lb, then used 15 mg for one month. It took me 18 months to lose 90 lb.

LevelThistle44archiveMay 9
↳ replying to @LevelFenwick49

You are on a good path with steady loss and still plenty of room to adjust. At 2.3 lb a week from roughly 290 lb you are losing about 0.8 % of body weight weekly. That pace would get you halfway to goal in another 20 weeks, well inside a safe timeline. Tirz works mainly by controlling appetite, so keep doing what maintains a deficit. Raise the dose only if a stall appears, not on a calendar schedule. Do not sit through unexplained weeks of no movement without acting.

CopperSignal27archiveMay 10
↳ replying to @LevelFenwick49

Many aspects of this process seem like the ideal result. Weight comes off at a sensible pace with almost no unwanted reactions, all while using minimal amounts, meaning one responds extremely well. The main benefit here is reaching targets likely prior to any leveling off or hitting the highest amounts. Since the target reduction is substantial, around seventy five to eighty five pounds, that's helpful given these medications may not always suffice for such amounts. There's little indication that very gradual adjustments or slower reductions modify the ultimate total lost over time. Such aspects haven't received much examination. Typically individuals cease reductions after roughly twelve months at peak levels, after accounting for buildup periods, simply due to the duration required for the reductions rather than diminished impacts. I'm unaware of any investigations involving prolonged minimal amounts followed by raises. Extended observations indicate stability at reduced levels persisting up to four years. Generally participants here tend to be overly cautious regarding amounts and might benefit from standard schedules, yet when smaller quantities function effectively with ongoing reductions and notably without constant cravings, indicating the medication is active rather than relying on willpower alone, then it's fine. There's ample opportunity to raise if reductions stall or stronger control is desired. The sole reason to move toward higher levels would involve conditions tied to excess weight such as elevated glucose, pressure, fats, cardiac concerns, particularly past middle age, since greater quantities prove superior in mitigating long term risks.

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