Users describe initial strong effects from tirzepatide that include sudden loss of interest in smoking, alcohol and food, plus calmer emotions and a sense of finally feeling normal. Several people report the improvements faded after months and old patterns returned, while others say the changes have lasted. A few note reduced frequency of vices even if they did not quit entirely.
What this discussion establishesWhether the positive changes persist long-term or eventually wear off
Still openWhy the effects last for some people but not others, and whether dose changes or switching medications could restore lost benefits
Nothing here is advice.
A free article looks at how GLP-1 drugs are being used for drug addiction.
Someone close to me is getting the same kinds of benefits plus better ADHD and emotional balance. It is striking to realize how much of my own behavior and reactions seem tied to insulin issues, because after five months on tirz everything now feels like what normal people experience. I stopped smoking in July without any trouble.
Thanks for posting that. I have seen pieces about help with addictions, ADHD and impulsive actions. My son has combined-type ADHD and trouble with emotions and other common issues. He began tirz two weeks ago and I hope it helps him beyond what it does for me, including his weight and food habits.
I went through something similar at the start. My ASD symptoms eased a lot and I felt like I finally knew what normal was like, with less anxiety and a better mood. That lasted months before things slowly returned to how they were before. At least my taste for red wine has mostly gone away.
Solid movie reference, though it was Robin Williams. Maybe taking a break from tirz and trying again, or switching to sema or reta, could bring back the states you liked better. Just an idea.
Same thing happened to me. At first it felt like an epiphany that people just choose to do things and follow through, but then it faded and I returned to my usual self, which I worry is not normal at all.
The movie comparison fits well then. In the film the doctor kept raising the dose to keep results going. Your experiences might justify a trial aimed at ASD or whatever is going on. There are probably others with similar stories. It sounds like something worth looking into rather than just accepting.
My test subject finally stopped smoking after using 5 mg tirz every five days. Previous attempts always failed around other people using vapes or cigarettes, but now there has been no nicotine and no temptation for weeks.
Interesting point. The only research I saw was about sema lowering autism-like behaviors in rats. GLP-1s seem to bring unexpected upsides for many, though they stick for some and not others. I am just glad I no longer drink two glasses of red wine every night.
I make whiskey from grain that comes from the ground, so it feels natural enough to me.
You probably should not let your test subject spend time with nicotine users or pick up smokes for them either.
Nice, and welcome to steady physiology. For the record I have been in solid recovery from several substance issues for years, yet there was still an odd twist in my thinking that has now mostly disappeared. It really does feel like seeing how normal people handle things.
I still do all my old habits, just far less often than before.
I gave up chewing tobacco years before these drugs existed and it was hard. I can still drink whiskey, but the hangover feels much worse on reta, probably from dehydration, so I stop earlier. Not the worst side effect.
I recognize that feeling from everyone who said they finally understood what normal is like. On my first week of tirz I had the same thought. I had not felt in charge of my body since I was a teenager, and the medication restored that in more areas than just food. It is good these drugs are getting attention for more than weight loss, and approval for other addictions could help a lot of people.
Today marks six months with no alcohol at all. An app says that saved over three thousand dollars and avoided more than a hundred eighty thousand calories that could have added dozens of pounds. Big win.
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