CommunityResults & Progress

Looking for weight loss brakes!!

19 replies16 peopleJul 20, 2026☆ Follow
Summary

How can someone on low-dose tirzepatide after duodenal switch surgery slow ongoing weight loss without stopping the medication entirely?

The thread shows that continued loss at 2.5 mg tirzepatide is common after major prior weight reduction and bariatric surgery with malabsorption. Participants report success by lowering the weekly amount further, splitting doses, or extending intervals between injections to 10-14 days while increasing calorie-dense food choices. The original surgery limits how much extra food can be absorbed, so dose reduction is viewed as the main lever. Several people describe similar experiences and plan to keep titrating down rather than quit.

What this discussion establishesStill open

Whether any dose exists that fully halts loss for every individual in this situation

Nothing here is advice.

19 replies · 16 people
WarmWillow50archiveopening postJul 20

I'm dropping weight faster than I want and it isn't leveling off. It sounds like a nice issue but at my age looking too thin isn't appealing and I'm heading there quickly. I'm 5'6 and 134 pounds yet carrying 8-10 pounds of loose skin on my midsection so my actual weight sits in the low 120s according to my doctor. I dropped from size 24 down to 4 and now some 2s fit. There aren't many of those sizes around and I worry I'll look unhealthy if this keeps going. Another 10 pounds would put me under a healthy BMI. Stopping the medication scares me so I've already reduced to 2.5 mg of tirzepatide yet the loss continues. The drug kills my hunger but the duodenal switch surgery from 2021 also leaves me absorbing only part of what I eat. Roughly 1500 calories with plenty of protein might give me just 950-1200 usable calories.

CopperSignal27archiveJul 20

The amount of food you describe is lower than what most expect for weight maintenance yet after years of big losses the calories needed to hold steady can drop a lot. Whether adding more food helps depends on absorption. If extra intake won't increase absorbed calories then the fix involves choosing foods that the body takes up more readily. If more food does help then the next step is reducing the tirzepatide amount until eating increases or weight stops falling even if that means going below 2.5 mg. This situation is easier to manage than the opposite problem of stalling at a higher weight.

WarmMeadow92archiveJul 20
↳ replying to @WarmWillow50 (opening post)

Instead of quitting could you stretch the time between doses? Stopping the medication worries me as well. You might also try going lower than 2.5 mg since nothing requires that to be the smallest amount used.

PatientBeacon15archiveJul 20

I would suggest lowering the dose and adding a quart of ice cream daily.

IronBramble31archiveJul 20

If the pen is the single-use type you could transfer it into a sterile vial and draw half the amount to test for the week. I tried something similar with another medication but it felt too strong so I moved on. Another option some try is adding a different compound though results vary.

LevelThistle44archiveJul 20

Reducing the amount or increasing the gap between doses is what others have suggested and it seems simpler than the reverse problem of trying to lose more.

WarmWillow50archiveJul 20
↳ replying to @CopperSignal27

That approach sounds workable so I'm going to try it. The pens I was given are single-use so I'll move the contents into sterile vials. I'd rather handle this situation than the opposite one even though it's unexpected.

PlainAlder11archiveJul 20

I'm dealing with something similar though not quite as extreme. I reached my second goal and beyond while on retatrutide at 9 mg and recently dropped to 6 mg. I still have the loose abdominal skin and plan to keep lowering the dose based on the scale. I was surprised to see skin remain after losing only a couple pounds a week.

IronKettle95archiveJul 20

You could also keep the same amount but change how often you inject such as every ten days or every other week.

RustBeacon82archiveJul 20

I'm in the same spot still losing at 2.5 mg. Next time I'll try 2 mg and if that doesn't work I'll start spacing the doses. I have some retatrutide but it raised my heart rate so I'm sticking with tirzepatide since I have a supply and want to avoid going back to constant hunger.

GreySparrow64archiveJul 20

Have you considered a carnivore approach with meat eggs and fat since those foods are nutrient dense and don't raise insulin much. The goal is to keep weight from muscle and bone rather than just any scale drop.

RustKettle57archiveJul 20

If 2.5 mg already cuts appetite sharply then going down to 2 mg or even 1 mg makes sense so you can eat more. Switching compounds is another idea some consider because hunger suppression can be milder yet I wouldn't worry about going lower on the current medication just to allow more calories.

SlowAnchor19archiveJul 20

Spacing shots to every 10-14 days is worth trying while you arrange lower doses. Also look at grocery habits and switch to full-fat versions of things you already buy such as yogurt chicken thighs or ribeye instead of leaner cuts. Adding butter cheese or nuts can help too.

WarmWillow50archiveJul 23
↳ replying to @GreySparrow64

I tried the carnivore way earlier but couldn't stay with it long. Forcing protein intake is hard since I'm not a big meat eater and I gave up after two weeks.

WarmWillow50archiveJul 23
↳ replying to @SlowAnchor19

Thanks for the suggestions. I already choose full-fat items because I absorb very little fat but too much at once can cause digestive issues. Still the idea of using darker meat cuts is helpful.

SlowAnchor19archiveJul 24
↳ replying to @WarmWillow50

I think I understand the digestive side effects you mean. Hope you find a way to slow things down.

RustKettle37archiveJul 25

I felt better overall on retatrutide except for low motivation and steadier blood sugar. I also went too low on weight even at 1 mg twice weekly and had to stop for a while to avoid losing more muscle. Micro-dosing or weekly shots still caused loss so now I'm trying other compounds to maintain instead.

LevelAlder29archiveJul 25

No new ideas beyond what others mentioned. Tiny amounts like 0.25-0.5 mg have been discussed by some. Spacing the dose also seems practical. On another note it's encouraging to hear someone who lost 200 pounds now fits into size 4s.

SlowLedger21archiveJul 25

I agree with lowering the dose. I'm currently at 1 mg per week split into two 0.5 mg shots and can eat normally while keeping weight steady.

GreyFenwick31archiveJul 26

No fresh advice beyond the dose reductions already suggested. Dropping to 1.5 mg or stretching the interval between shots could help along with plenty of protein. It's inspiring to see such a large loss and reaching small sizes and I'm glad the earlier information helped ease some concerns.

Add your experience

If you have tried it, this topic is still open. Sign in to reply — it takes a minute.

Looking for weight loss brakes!! · ZyraTrack Community