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NAD+ gelling in fridge after reconstitution

3 replies3 peopleJun 26, 2026☆ Follow
Summary

Why does reconstituted NAD+ turn into a gel or form particles in the fridge and how can it be fixed or avoided?

The gelling happens when the vial sits too close to the fridge fan and gets too cold, causing the NAD+ to come out of solution as a cloudy mass or white grains. Moving the vial to a different spot or using a plastic box stops the problem, and letting it warm to room temperature followed by filtering restores a clear liquid. People report no issues when reconstituting 500 mg with 3 ml or 1000 mg with 6 ml of bacteriostatic water.

What this discussion establishesStill open

Whether buffered NAD+ needs a different pH or solvent than ordinary bacteriostatic water.

Nothing here is advice.

3 replies · 3 people
WarmAnchor59archiveopening postJun 26

I kept my mixed NAD vial in the fridge around 37 degrees after it dissolved fine at first and caused no trouble for the initial uses. This time it had formed a cloudy gel stuck at the bottom. The listed temperature range seemed suitable per the guides and none of the other vials on the shelf showed any ice or crystals so it didn't get too cold by mistake. I let it sit out for about fifteen minutes while turning it gently and it turned back to liquid but with tiny white gritty specks floating around. After running it through a filter it looked clear so I tried another dose and felt normal. One checker suggested mixing with twice as much fluid since the strength was too high while the guides called for even less than the amount I chose. Not sure what caused the texture shift or how to stop it happening again.

WarmAnchor46archiveJun 26

I have a reconstituted bottle of 500 mg. I reconstituted at 3 ml. No issues. I have some 1000 mg coming and plan on just using 6 ml to reconstitute. Sorry to hear you are having problems.

WarmAnchor59archiveJun 27

Additional observations here. I tried shifting the container to another spot inside the refrigerator and put it inside a plastic holder. The thickening no longer happened. It simply required shielding from the cooler's direct airflow.

RustAlder28archiveOct 13

Today I mixed up a vial of that buffered NAD+ using regular sterile water and now it's turning thick and gel-like too. Wondering whether the buffered kind calls for a different acidity level or some other liquid besides the usual kind. I've been checking around the site without finding what I need so figured I'd revive this old thread.

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NAD+ gelling in fridge after reconstitution · ZyraTrack