Psoriatic Arthritis and Golimumab (biologic treatment)

Since you're in the UK, would your doctor be open to the peptide approach? In the US it's mixed. I wouldn't mention it to primary care but my rheumatologist is supportive if it works responsibly. The reason I'm asking is to check for any interactions, especially with copper, alongside your current treatment.

I have psoriasis, psoriatic arthritis and fibromyalgia too. If you don't mind sharing, what reaction did you have to Simponi? I was on the IV version and it stopped working after a few months. My body seems to become immune to whatever shot they try around the six-month point. I've been through all the usual ones and keep switching. Could have been the Simponi or maybe just me. Sorry if that's too personal.

No problem, not too personal at all. Symptoms started gradually over six months in the right knee and whole foot. Went on DMARDs, then followed guidelines to try two before qualifying for biologics. Got Simponi free of charge. No flare, swelling or reaction in nearly 15 years. Since then I've done triathlons and time trials at UK level while working as a firefighter and fire behaviour instructor. Rarely catch colds even when my wife brings them home from school. Wondering if one injection every two months might work, as suggested by my rheumatologist. Hope you find something that helps. How many have you tried and have you looked into this much?

I've tried Humira, Enbrel, Cosentyx, Taltz, Stelara, Simponi and now Tremfya, which isn't fully clearing me and seems to be losing effect already. To be honest I didn't read much because I assumed the doctors knew best. Now seeing it as more about money than patient health, I'm exploring other options. Started Sema and Nad+ last year and my arthritis improved a lot, even mobility the day after the shot. The fact the FDA won't approve peptides that help so many conditions tells me money is the priority, since healthy people would cost them billions.

I don't mind sharing. Similar situation here, tried many drugs for RA and they either stop working or cause bad reactions, so I'm a tricky case. After the fourth Simponi IV dose I had a full flare with migraines, swollen lymph nodes and sore throat for weeks, still flaring now. Went from thinking I was in remission for a year to a complete setback. Looking for alternatives. These diseases can really drain you, sorry for the rant.

Good summary, cheers. The half-life detail is interesting. I'll keep an eye on moving from six weeks to eight weeks. Been lucky with no issues and life back to normal, completely asymptomatic. Also fortunate that I hardly get common colds, even though my wife is a teacher exposed to everything at school.

100 percent agree. If you've found something that works and you've been stable for years, I wouldn't experiment with changes. My partner is on their third biologic with little success. If the medication doesn't interfere with daily life then you've won the lottery.