Suggestions for adjusting tirzepatide dose due to side effects

You could test 5.5mg or 6mg or 6.5mg instead. Another option is injecting 5mg every five days or splitting into two smaller shots of 3mg or 3.5mg per week. Plenty of ways to adjust.

I would keep using Tirz as long as it continues working. It is a strong medication and I would stay on it except that higher doses make me feel down. If the side effects feel too strong, lower the amount, perhaps to 6mg.

No requirement exists to increase the dose every four weeks. Stay at the smallest amount that still delivers results. Since Tirz is still effective I would not combine it with reta yet and would only raise the dose later if needed.

What matters is the destination, not the speed of arrival.

Docusate sodium can help with constipation when needed. I would stay at the current level for a few weeks before making changes. In my experience early nausea often came from still eating too much.

Another vote to stay on Tirz. Just because reta is sitting there does not mean it has to be used right away. Most people who switch or combine do so when their current medication stops working, but here the opposite is true. With these medications easy to obtain it is tempting to add more than needed. 7.5mg is already a big jump from 5mg so lowering it a little could reduce side effects and make the supply last longer.

Okay everyone, I just did the injection and chose to go down to 6mg. I will see how the next few days go and might add a small amount on Sunday if needed. Appreciate all the input.

Phillips Milk of Magnesia works very well for this.

Update: while I was on 6mg the side effects stayed about the same as at 7.5mg but felt slightly milder, so I moved down to 5mg. Three days after that injection the effects are now much lighter. I will continue at 5mg as long as it works. Last week I lost 1kg.