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Will switching from Tirz to Reta bring back resolved IBS symptoms?

6 replies4 peopleMay 1, 2026β˜† Follow
Summary

Will IBS symptoms that resolved on tirzepatide return after switching to retatrutide?

The original poster saw complete resolution of long-standing morning IBS on tirzepatide from day one and worries the effect might not hold on retatrutide due to its different receptor profile. Other users note that retatrutide adds glucagon activity but should not reverse the bowel benefits in theory; one reports gastric slowing was milder on reta yet still better than baseline, while another with colitis found major diet changes and weight loss produced the biggest improvement and stayed stable after adding reta on top of tirzepatide.

What this discussion establishesStill open

Whether the original poster's IBS would actually return upon switching to retatrutide.

Nothing here is advice.

6 replies Β· 4 people
AmberCinder18archiveopening postMay 1

I've had IBS for more than 40 years where breakfast always sent me to the bathroom within an hour. It vanished completely the first day on Tirz and bowel movements became normal. The slowed emptying on Tirz is probably why, but I'm wondering if the IBS would come back on Reta because its mechanisms differ. Anyone have experience with that?

NorthBramble68archiveMay 1

It's not that the actions differ at all, simply this compound hits an extra receptor for glucagon along with the others that the similar medication does. I don't think there would be problems in theory, yet I found it necessary to keep taking the original pair during the process of slowly raising the amount of the new one and lowering the previous, finally stopping after a few weeks span. I picked a time with fewer demands just in case the digestive problem flared up again.

AmberCinder18archiveMay 1
↳ replying to @NorthBramble68

Being done with my job leaves me with extra free time every day. πŸ˜† Yeah that tip helped a lot so thanks for sharing it. I still haven't bought any reta though and keep holding off while I wait around without knowing what I'm expecting.

LevelThistle44archiveMay 1
↳ replying to @AmberCinder18 (opening post)

My restroom trips during slowed digestion felt nicer on the earlier compound than on the later one, yet the later one still beats the starting point most of the time. Just raising the intake levels lately might be making me rate that improvement too low. What draws you toward switching over to the later one?

AmberCinder18archiveMay 1
↳ replying to @LevelThistle44

I'm uncertain about making any switch myself and mostly wanted to understand more about this other option along with how the overall experience might differ from what I'm using now. Progress has been solid so far since I've dropped around thirty pounds across just over twelve weeks yet still have further to go. This alternative sits in the back of my mind as something to consider later if the present approach reaches its ceiling or loses effectiveness though those situations feel far away at the moment. The main reason for asking came from having dealt with bowel problems for four decades and not wanting to even consider that issue coming back so I wondered whether others have seen it return after using what I'm on.

LevelThistle44archiveMay 1
↳ replying to @AmberCinder18

Questioning the remaining distance, I've shed fifty-three pounds from December onward after beginning with Tirz. From January when Reta began, the loss totals forty-three pounds, leaving roughly forty more. Changing over to Reta, I escalated the amount quite strongly, aiming to boost my chances of outperforming typical trial outcomes, where roughly twenty-four percent saw thirty percent or higher reduction with the maximum twelve milligrams. Targeting a total somewhere around thirty-two to thirty-five percent instead.

CopperSignal27archiveMay 2

My condition involves ulcerative colitis along with persistent issues that could stem from incomplete remission or diarrhea-dominant IBS or perhaps both. Major shifts in how I ate combined with dropping seventy kilograms produced the clearest improvement. Cutting total daily intake made a noticeable impact, just like spacing out smaller portions at each sitting and lowering my FODMAP consumption. Beginning one weekly injection brought further relief that carried over after switching to a different option at fifteen milligrams, and adding a third compound at five milligrams left things unchanged. I kept using the second medication because side effects stayed minimal while my digestion remained steady and I saw no point in potentially upsetting that balance. The problems have eased considerably though they have not disappeared entirely.

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