ForumDosing & Titration

Wolverine stack and mitochondrial protocol and staggering pins

7 replies3 peopleJun 3, 2026☆ Follow
Summary

optimal TB500 and BPC157 dosages for injury recovery plus mitochondrial repair sequence with MOTS-c SS-31 and NAD+

The thread shows one user reporting clear but temporary gains from BPC and TB on longstanding soft-tissue issues tied to hEDS and questions whether to raise doses on the second cycle. Others dismiss any formal mitochondrial peptide protocol as unnecessary and stress that basic supplements and nutrition outperform most peptides. Several participants note real-world cases of people experiencing side effects or stalled progress from calorie deficits and missing electrolytes while using other compounds.

What this discussion establishesWhere people disagree

whether peptides offer advantages over ordinary supplements and nutrition for mitochondrial or recovery goals

Still open

what specific dose increases if any would be appropriate once current results plateau

Nothing here is advice.

7 replies · 3 people
RustLantern55archiveopening postJun 3

I have two main questions. The first is about the Wolverine stack and the second concerns the MOTS-c SS-31 and NAD+ approach for improving mitochondrial performance. What doses of TB500 and BPC157 work best for active recovery? This is my second cycle and I feel I should increase the amounts. I deal with many soft tissue injuries that never healed several of which would have needed surgery that I skipped for various reasons. During the first cycle I saw clear improvement in my knee and especially my hands and wrists. Once I stopped the cycle pain returned within a week my hands swelled again and I could not flex my fingers in the morning while carpal tunnel symptoms came back. Most of those issues had eased during the first cycle though not completely and the change was encouraging. I also have hEDS a connective tissue disorder that explains why these injuries keep happening. Right now I take BPC at 500 mcg daily and TB500 at 500 mcg every third day. I am starting adult league softball again and already my i

QuietSignal61archiveJun 5

Try adding Cartalax to the BPC and TB. The usual amount is 0.5 mg twice daily but you can go up to 1 mg twice daily if you want. I found three times a day worked better for me and plan to try that again with a pen. The second question is just nonsense and there really is no set protocol. Simply top up your NAD first then add the SS31 and after that start the MOTS-c. Honestly I do not understand why more people do not consistently use CoQ10 PQQ berberine and similar compounds alongside this if they actually want stronger mitochondria. Folks hear about peptides and ignore everything else even though many ordinary supplements are better studied and more effective.

CopperMarble29archiveJun 5
↳ replying to @QuietSignal61

Accurate. True af lmao. Supplements and nutrition are literally the foundation. All of that stuff is valid and peptides are not better solutions nine times out of ten.

QuietSignal61archiveJun 5
↳ replying to @CopperMarble29

It absolutely freaks me out that some people blast peptides and steroids yet skip even a basic multivitamin from the store. I suspected that users having serious AFIB episodes from reta were simply malnourished. When I asked one person what other supplements they took and whether they used magnesium or potassium they said they took nothing else and would not take those minerals because of their heart. Classic chicken and egg situation.

CopperMarble29archiveJun 5
↳ replying to @QuietSignal61

The malnourished reta observation is real and I had not considered the AFIB connection before but it makes sense. I have spoken with peptide users losing hair from poor nutrition and others at 25 BMI running reta in a thousand calorie daily deficit who report losing muscle and energy. People stop thinking sometimes. The body needs nutrition and while large fat stores might let you manage a big deficit for a while you still require electrolytes and protein. Just because hunger disappears does not mean dietary needs go away. A lot of the time the answer is simply going back to the basics rather than expecting a magic injectable to fix everything.

QuietSignal61archiveJun 5
↳ replying to @CopperMarble29

Dude I know someone who thought he was going bald only to discover he was not taking a multivitamin. A pale twenty six year old with an eating disorder is not getting enough nutrition. He would not buy the vitamin D I suggested but he went out for a prescription for oral finasteride and minoxidil. Too personal. I am on a twelve hundred calorie deficit and not strength training so I am turning into a complete twink. Up until I added high dose SLU my energy stayed great because I stay strict with nutrition. Being honest I am kind of tired now though. Do not even get me started on the crowd that claims they need Tesa because it targets visceral fat.

CopperMarble29archiveJun 5
↳ replying to @RustLantern55 (opening post)

For the first question I would keep doing exactly what you are doing. You already have results so follow the minimum effective dose rule. Continue until it stops working and only then consider raising the dose or frequency. Make sure you eat enough food rest the muscles and avoid adding extra stress. For the second question I agree that it is all nonsense.

CopperMarble29archiveJun 5
↳ replying to @QuietSignal61

This is personal for me too. I train two and a half to three hours a day at 24 BMI doing thirty to forty minutes of cardio plus heavy lifting and I compete in hybrid endurance sports. I tried reta hoping to lose fat and build muscle but spent two months wondering why the scale dropped while my fat stayed put and I got weaker. I looked like a washboard at the end. Once I counted macros I realized I was in an eight hundred calorie daily deficit. I stopped reta raised calories to plus two fifty and like a switch I began losing fat and building muscle. The before and after photos went from washboard to jock in just over two months. The Tesa crowd is funny though. Nine out of ten of them seem to think tesamorelin works because it is magic or has some secret pathway rather than simply making the body release growth hormone.

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