KeenPebble33

archive participant · first seen Mar 31, 2026 · last active 4d
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Anyone Switch From Reta to Tirz?
I went through this change. I began on Tirz and the hunger control was solid with steady weight drop. I tracked daily weight, waist size, e…
May 2
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Eloralintide (LY3841136) discussion from discovery to potential use
I would pay extra for it. I am nearing maintenance and an amylin agonist with minimal sides looks like a solid way to taper GLP-1 doses. So…
May 1
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Stalled on Tirzepatide titration after Zepbound 15mg – Should I jump to 10mg?
Given the previous use I believe raising the amount to ten milligrams should go smoothly. After that spend a couple of weeks there before m…
May 1
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Stopping and Restarting Certain GLP-1s to Lose Weight May Make the Drug Less Effective
These medications are gaining attention in longevity circles for heart benefits and lower mortality risk. More people at normal weight are …
Apr 30
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Stopping and Restarting Certain GLP-1s to Lose Weight May Make the Drug Less Effective
Thanks for sharing that study. It matches what I went through. The steep rebound after week 176 is especially striking and is one reason I …
Apr 30
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Eli Lilly phase 3 Eloralintide trial is enrolling for Plateau Busting research
That is a super interesting study. There is synergy between cagri and sema so I will be interested in the synergy of elora with tirz since …
Apr 29
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Stopping and Restarting Certain GLP-1s to Lose Weight May Make the Drug Less Effective
I have no faith in the reset idea. My results show clearly that it does not happen. It is also very frustrating to lose months of progress …
Apr 29
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New quintuple agonist from Eli Lilly! So new it is not yet named.
I see your point. There's a chiral center in those meds that mass spectrometry can't pick up, as you said. That means we could be receiving…
Apr 29
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New quintuple agonist from Eli Lilly! So new it is not yet named.
The whole idea of hitting five receptors at once feels like mostly hype since going after calcitonin does nothing to help drop weight and m…
Apr 29
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Stopping and Restarting Certain GLP-1s to Lose Weight May Make the Drug Less Effective
I can confirm this from my own experience. I stopped tirz for roughly two months thinking I would be fine. The weight came back fifteen pou…
Apr 29
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What do you guys think about DNP?
Like the others said I would not touch it. The safety window is very narrow with little room between helpful doses and ones that can cause …
Apr 29
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Eli Lilly phase 3 Eloralintide trial is enrolling for Plateau Busting research
Imagine what stacking it with reta or even tirz could do. Lilly is way ahead of Novo.
Apr 29
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Eli Lilly phase 3 Eloralintide trial is enrolling for Plateau Busting research
They turn out to be rather unlike each other in their makeup. The first one doesn't zero in solely on those amylin receptors numbered one a…
Apr 28
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What am I doing wrong
Have you checked the pH of the solution? That would be my first step. Begin with bacteriostatic water and measure its pH, then add tiny amo…
Apr 26
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Anyone successfully cycling SSRI?
For SAD specifically, check your vitamin D levels and consider up to five to ten thousand IU daily during winter. It may not help but tryin…
Apr 26
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Anyone successfully cycling SSRI?
Prozac is simpler to taper due to its long half-life, yet it affects libido more than some others. Lexapro differs from Prozac, Zoloft, or …
Apr 26
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Anyone successfully cycling SSRI?
What long-term issues worry you? They are generally considered safe with plenty of data. You could try cycling but it is not advised, and y…
Apr 26
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Scientists remove “zombie” cells and reverse liver damage in mice
BCL-2 family expression does not directly cause cancer because these are not true oncogenes. They do not drive cell division or new vessel …
Apr 23
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Doses Where Tirzepatide and Retatrutide Start Working for Weight Loss and Stacking Experiences
That is what the data indicate. There is little difference between 8 mg and 12 mg for reta. On tirz I had no sides at all and actually felt…
Apr 23
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Psoriatic Arthritis and Golimumab (biologic treatment)
Hate to be the bearer of bad news but Golimumab is a very strong inflammation blocker, which is why remission is complete. Doubt any peptid…
Apr 23