ForumInjection Technique

Pens or Insulin Needles for Injections?

47 replies28 peopleMar 11, 2026☆ Follow
Summary

Pens versus insulin needles for daily peptide injections, including reuse and mixing concerns

Users report going through multiple insulin needles daily with stacks and note that alcohol cleaning removes the coating and increases discomfort at sites. Pens are praised for providing a fresh sharp needle each time without first dulling it on a vial, making them convenient for frequent low-dose injections, though some find filling and setup fiddly. Many continue with single-use syringes for simplicity, ability to mix compounds at injection time, or because their doses do not justify pens. Reuse of needles is widely discouraged due to dulling and contamination risks.

What this discussion establishesWhere people disagree

Whether peptides can safely be mixed in the same syringe at injection time

Still open

Whether pens are worth the extra steps for users with varying daily stacks

Nothing here is advice.

47 replies · 28 people
SteadyTimber31archiveopening postMar 11

Hello again! Lots of people here mention pens. I've stuck with insulin needles, but that means going through 5-6 a day depending on my stack. I tried wiping them with alcohol, only to learn it strips the silicone layer and makes the injection sites hurt more. Curious what others think about whether pens are worth getting.

ClearLantern88archiveMar 11

I have pens and prepare them for family members, but I mostly prefer a syringe for myself. For low-dose items where a vial lasts a long time, a pen makes sense. With bigger doses like glutathione where a vial only lasts a few shots, the pen feels like extra hassle. I never reuse syringes. The pen advantage is getting a fresh sharp needle every time since it does not get dulled drawing from the vial first.

IronBramble31archiveMar 11

Besides GLP-1s, most peptides can be mixed together in one syringe right before injecting. I began doing this after my doctor said he does the same. Never premix and put the syringe back in the fridge.

WarmHarbour52archiveMar 11
↳ replying to @IronBramble31

I've been using NAD+, GHKCU, and glutathione together lately. Is it alright to mix all three into one syringe?

LevelTimber64archiveMar 11
↳ replying to @SteadyTimber31 (opening post)

Are you reusing your insulin needles? Please do not. It is not hygienic. Insulin needles are meant for single use only and are inexpensive. I use insulin syringes because they are straightforward with no extra parts. 31g 5/16 inch for smaller doses and 1ml for larger ones.

BlueAlder28archiveMar 11

I use insulin needles for the weekly Tirz dose. I received a large supply from a family member who has diabetes. I recently started an auto pen for GHK-Cu because reaching the glute daily would be awkward with a syringe. The auto pen button needs a firm push though, and I wonder if the 32ga needles are too fine.

PlainAnchor67archiveMar 11

So far I've only used the thirty gauge variety for my insulin injections. A pen is something I've yet to try.

WarmWillow50archiveMar 11

I'm a syringe person. Pens sound good to avoid accumulating used syringes, but I am impatient and doubt I would keep up with filling one each time. I have a monthly subscription of 100 syringes delivered so I do not have to think about it.

PlainAlder11archiveMar 11

I use BD 31G 5/16 .05 and 1ml syringes. I cannot imagine doing 5-6 pins a day.

WryQuill22archiveMar 12
↳ replying to @WarmWillow50

Do you go through that many in a month? Personal use or for the animals too?

WarmWillow50archiveMar 12
↳ replying to @WryQuill22

That amount covers me, my son, and the dogs. Horses get separate larger needles because their skin is thicker and a 31g would bend. I also give some peptides to friends and family and include syringes sometimes. When running a full stack I can pin 3 to 5 times a day which uses up spares quickly. I usually combine several into one syringe but adding Tirz and another cycle turns me into a pincushion.

ClearBeacon24archiveMar 12
↳ replying to @WarmWillow50

I go through 2 boxes a month. I'm a guinea pig.

ClearBeacon24archiveMar 12
↳ replying to @WarmWillow50

Have you used epitalon on your dogs? I give it to mine.

LevelTimber64archiveMar 12
↳ replying to @ClearBeacon24

That recurring payment option looks promising.

SharpThistle74archiveMar 12
↳ replying to @WarmWillow50

If you are impatient a pen is a big improvement. Filtering into the cartridge after reconstituting is straightforward and you avoid drawing with an insulin needle every single time. Just wipe with alcohol, attach the pen needle, dial the dose, and inject. No need to check syringe accuracy.

WarmWillow50archiveMar 12
↳ replying to @SharpThistle74

Interesting. I may try one just to see. I would not mind having fewer used syringes around.

ClearWillow59archiveMar 12

I use 30mg vials of Tirz and Reta. I reconstitute each with 3ml bac water then filter each into its own cartridge. That gives 27 doses of each so 54 syringes saved. That also means 54 times I avoid injecting possibly contaminated air into the vial or dulling a needle before injecting. Since I also pin other items daily the savings add up.

ClearWillow59archiveMar 12
↳ replying to @SteadyTimber31 (opening post)

I'm currently using the V1 pens and find them quite satisfactory. Being able to position them precisely lets me select spots that feel less tender, since I can press the tip to my skin first to check. They also deliver the dose quickly. The variety of hues helps me tell them apart without needing any tags.

PlainCompass54archiveMar 12

Using a pen made things simpler for me. Pen needles also take up less space in the sharps container so it fills slower. It is only a few extra steps after reconstituting which I am already doing.

PlainQuill53archiveMar 12

My only experience with pens is the prefilled GLP auto injectors and they can feel forceful. Yet I feel nothing with the 30g insulin needles.

ClearBeacon24archiveMar 12
↳ replying to @ClearWillow59

You all are too worried about small things.

SharpThistle74archiveMar 12
↳ replying to @PlainQuill53

Very different. I feel nothing with the pens either.

SteadyTimber31archiveMar 12
↳ replying to @IronBramble31

Interesting. I follow one doctor on YouTube who said you should never mix peptides in the same syringe. There is a lot of conflicting information.

SteadyTimber31archiveMar 12
↳ replying to @LevelTimber64

I've kept using the same ones multiple times over. I let the needle sit in alcohol first, then pull that liquid all the way through the needle and into the syringe body. Replacements aren't pricey, yet it bothers me to throw out several after just a single use. Still, I came across info saying this takes off the lubricant layer, and it causes a little pain during injection.

WryQuill22archiveMar 12
↳ replying to @SteadyTimber31

Not sure about coatings but the tip gets much duller after one use. There are pictures showing how jagged they become. I would not want to deal with that. It puts the body through extra trauma and you cannot fully disinfect it anyway.

LevelWillow41archiveMar 12

I've only ever considered insulin needles and reusing them seems wrong to me. I am curious about pens but not sure exactly how they work.

KeenAlder60archiveMar 12
↳ replying to @SteadyTimber31 (opening post)

Normally the pens work fine for me except at exactly one milliliter when the syringe becomes the better option.

ClearMeadow73archiveMar 12
↳ replying to @SteadyTimber31

I am sensitive and even the bluntness from piercing one vial top is bad enough. That is why I like pens, they stay sharp.

NorthAnchor93archiveMar 12
↳ replying to @ClearLantern88

Do you pin the glutathione subcutaneously or IV? What benefits have you noticed? Thinking about it for skin.

PlainQuill53archiveMar 12
↳ replying to @SharpThistle74

I bet the nicer ones are good. That is why I wanted to clarify that my only experience was the auto injectors for my medication. Those shoot the whole dose fast while I take about 10 seconds by hand.

LevelTimber64archiveMar 12
↳ replying to @SteadyTimber31

Yes there is conflicting advice. I take the conservative approach on these things. It reduces my anxiety.

LevelTimber64archiveMar 12
↳ replying to @SteadyTimber31

I can't figure out why anyone would bother reusing those needles. After one shot I toss the whole thing straight in the trash. The insulin kind aren't built to handle more than a single use. Trying to stretch them further just doesn't add up to me.

ClearMeadow73archiveMar 12
↳ replying to @PlainQuill53

I have used the autoinjectors so I know what you mean. I have a couple of the V2s and you control the rate as you push so it is much better.

GreyLedger40archiveMar 12
↳ replying to @ClearBeacon24

Learning that I could give peptides to my dogs. Is there a trusted source of pet-peptide information?

PlainQuill53archiveMar 12
↳ replying to @ClearMeadow73

Ah now I get where I went wrong before. I used to figure these worked just like the automatic devices which forcefully push the medication in.

ClearWillow37archiveMar 12
↳ replying to @SteadyTimber31

I always grab a fresh needle instead of going for another round with the same one. Swiping it with alcohol fails to clean it properly. That just taints the mix and opens the door to nasty infections like cellulitis or worse.

ClearWillow59archiveMar 13
↳ replying to @ClearBeacon24

I prefer splitting things into smaller amounts taken more often. Like what came up before about getting twenty seven uses out of one container across fourteen weeks. That setup raises the odds of germs getting introduced quite a bit during the needle routine, since I push air in from the washroom first to pull the liquid. I wipe down with cleaner anyway but the risk lingers. Switching to a device drops those odds to basically nothing. It just seems obvious.

ClearWillow59archiveMar 13
↳ replying to @PlainQuill53

I depress the rod one notch at a time based on the pace I pick.

AmberMarble84archiveMar 13

I have several brand-name pens but they started malfunctioning. I do not use many peptides these days and am tired of pinning. So right now I just use insulin needles.

SteadyAlder49archiveMar 13

I am planning to switch to a pen once I settle on just one item instead of cycling through many stacks. Right now I go through 2-3 boxes of insulin syringes a month.

WryLedger42archiveMar 13

Another small advantage with pens is that the needles are often available on pharmacy shelves so you can pick them up without ordering online.

SlowTimber14archiveMar 13

Yes we use both pens and insulin needles. It depends on the peptide, the injection schedule, the dosage, and other factors that decide whether to load a pen or just use a syringe.

SteadyFenwick85archiveMar 13

I'm a needle person for my reta and TRT. Insulin needle for reta and a slightly larger gauge for TRT. Both subq and almost always painless.

GreyLedger40archiveMar 13

I meant more which peptides are good for dogs and what dosages. Like this forum but for pets.

ClearBeacon24archiveMar 13
↳ replying to @GreyLedger40

Sure why not include dogs? There is already a thread just for cats on here.

ClearLantern88archiveMar 18
↳ replying to @NorthAnchor93

Subcutaneously, and I do a full pen or full 1ml syringe in my butt. I found it the fleshiest and least painful spot. Also the 1/2 inch 29g pen needles are the least painful with glutathione. Shorter thinner needles leave welts and burning.

LevelCinder55archiveMar 18

I've used both. I used pens with Trulicity and Ozempic and liked them better though they are one-use. I have looked online for pens and feel overwhelmed by the options and lack of usage details in the ads. At some point I will switch. I hate filling syringes and dealing with the used ones.

AmberTimber24archiveMar 18

I picked up a few of these pens some time ago. The recent models use plastic for all the inner parts and get produced in Poland. Various web stores based in that country carry them. One reached me through an overseas seller on a trading site. I checked dosing accuracy on a single unit across 10 to 50 and it matched exactly.

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