Quite a few folks report feeling more tired when taking bigger daily amounts in the 250-500 milligram range, and some may also require extra methylated folate plus B vitamins to feel better. To check the situation I got tests for B12, folate, homocysteine, ferritin, CBC and TSH levels. When the body clears extra nicotinamide from NAD+ breakdown by methylating it, that pulls methyl groups from SAM-e which uses the pathway relying on folate, B12, B6, riboflavin and betaine. So doses over 200 milligrams could strain methylation if folate and B vitamins are low, causing fatigue or brain fog sometimes. Being my first time with NAD+, 200 milligrams at once was pretty high so I kept below 100 milligrams the first week to see how I reacted.
I was hoping NAD would give me energy since I'm nearly 60 and have read that other people get instant energy from injecting it. Instead I feel tired and fatigued right after, and it lasts maybe 20-40 minutes before I feel normal again. At 200 mg it was much worse with headache and dizziness and I almost fainted, so now I stick to 75 mg and have finished my first 1000 mg bottle. I've seen that some people react this way. Does that mean NAD isn't good for me? For others who take NAD, does it give instant energy or short-term tiredness like I'm getting?