What to do for last 20lbs on Tirz @ max dose

I've been running 19.5 mg total for two or three weeks now, split as 12.5 or 13 mg mid-week and the rest on Saturday. Started dropping a couple pounds weekly until vacation threw everything off and I gained five back. If I'd stayed on plan I probably would have been fine. Same situation here, started around 270 aiming for 250 and giving myself six more months. If it happens, great; if not, I've still dropped 60-70 lbs. What comes after that six-month mark, I have no idea.

I like checking the actual trials since there's not much else to go on. That's why I'm treating a year and a half as a checkpoint. Losing over 100 lbs already means you've won, perspective matters. These forums can make it sound like everyone just takes the meds and hits their number without effort. Studies show decent success rates but still only a percentage. I'm older and the extra weight loss won't change looks much at this point. Another 20 lbs would be nice but probably won't move the needle that dramatically. Wish 15 lbs was just a few good bathroom trips, but those days are long gone.

Just finished my 61st tirz shot and still have 14 lbs left after losing only half a pound in five weeks. Food cravings are returning and it feels like the medication stopped working. Last shot at 20 mg instead of 15 mg made a clear difference with cravings gone again. Tried 17.5 mg earlier and noticed nothing extra over 15 mg. Hope this doesn't mean doses have to keep climbing.

If you're not truly plateaued, just keep doing what worked before. Increase exercise intensity with some high-intensity intervals, shift focus toward building muscle instead of pure scale weight, and accept the final pounds usually come slowly.

Halfway between your next 17 mg tirz doses, add 6 mg reta and drop tirz to 12-15 mg. Wait 24-48 hours, check how food noise feels, then decide whether more tirz is needed before the following reta dose.

If the sema stack was working well I'd just keep going with it. The two meds complement each other on different receptors. Stay on both until goal, then drop sema and hold with tirz alone. Those last few pounds are always the toughest.

Cagri is my next move once I move from 15 to 20 mg tirz. Reta didn't sit well and the survo combo wasn't worth the sides.

The last 10 lbs were rough for me too. When 15 mg tirz stalled I went to 20 mg. When that stalled I switched to 20 mg every six days, then every five days for the final month with no bad effects. Maintenance is 10 mg tirz plus occasional 2.5 mg mazdutide. Still have cagri and reta in the freezer if needed.

My starting point was different since I began GLPs mainly for hunger control after already losing weight. Added a modest reta dose to 15 mg tirz because low-dose reta showed decent loss in studies. Ended at 15 mg tirz plus 5 mg reta and dropped another 13 kg over nine months with less hunger on the combo. Kept side effects low compared with higher reta alone or prior sema experience. Another route is low-dose cagri, though it may bring more nausea or fatigue depending on individual tolerance.

Could always try adding sema again and see how sleep goes.

What worked for me after plateauing the last 60 days to reach 200 from 280 was dropping from 15 mg tirz to 12.5 mg one week, then 10 mg for three weeks while shifting toward maintenance. Talked myself into needing 20 more pounds, went back up to 12.5 then 15 mg, and lost another 14 lbs in five weeks. Sometimes backing off briefly helps push through the final stretch.

Skipping the parts I don't think would land well, the last 20 lbs on a GLP can end up feeling a lot like losing the first 20 lbs before any GLP. No single best method, just different ones that work person to person. Cagri lines up with your approach since it works differently and should let you eat even less. Glucagon activity through a reta-style mix would be next, with added sema helping keep hunger down. Full switch to reta would probably come after because of the chance of stronger hunger returning for a while.

Adding sema back looks like the strongest option since you already know it worked and have it. Stacking reta is the other one worth trying. Currently stalled on reta myself and planning to add tirz soon. Nice to be able to experiment with combinations.

I'm on the other side. Reta has been strongest for me. At 10 mg I could barely eat at first, then it settled. Now at 12 mg it's working well and I've also stacked 8 mg sema. In my experience 4 mg sema feels roughly equal to 12 mg reta.

Reconstituted cagri with BAC for a year. Currently on 12 mg tirz, 2.4 mg sema, and 2.4 mg cagri weekly on different days. Down 110 lbs and at goal. They all work and cagri helps offset the tirz chill.