Scientists remove “zombie” cells and reverse liver damage in mice

You have part of it; GLP-1s seem to act as senomorphics yet they do not function as actual senolytics.

That holds, though I am still checking whether today's senolytics really beat senomorphics. The present ones destroy too many cell types and most users would likely do better with the milder approach.

I would rather remove the source of trouble than just calm it down. The study used senolytics and the mice got better, so I doubt the same result would appear with quercetin alone though it might. After more reading I saw GLP-1 RAs raise BCL2 levels, a protein that blocks cell self-destruction, which works against senolysis and could interfere with agents like D+Q. It is a side note but several cancers also use higher BCL2, yet the broad anti-inflammatory action of GLP-1s may offset that risk. Here is a table an AI made.

That assumes the treatment only removed the intended cells. The mice did improve but we still do not know if a senomorphic would have produced a stronger result.

You are correct that we cannot know from existing data, yet I expect advantages from clearance. Other work already points the same way. FOXO4-DRI shows the best selectivity by hitting only cells with active p53-FOXO4 complexes. Fisetin gives the strongest oral senolytic effect on lifespan. D+Q produces different results in males versus females when started early. Quercetin by itself improves healthspan but adds no longevity gain. GLP-1 RAs work as senomorphics by lowering SASP without removing the senescent cells.

Have you used FOXO4-DRI yourself? I have been looking into trying it.

That gives a fine reason to eat more strawberries, which I put in my oats each morning. Searching PubMed for fisetin will lead to plenty of solid reading.

BCL-2 family expression does not directly cause cancer because these are not true oncogenes. They do not drive cell division or new vessel growth but simply help cells survive, which is not always harmful. Once cells already carry oncogenic changes, however, extra BCL-2 clearly links to worse results.