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Skipped doses and still working?

9 replies7 peopleSep 30, 2026☆ Follow
Summary

Why does strong appetite suppression from tirzepatide continue for weeks after skipping doses in maintenance, and how should dosing be adjusted?

Users report that appetite and hunger control remain high even two weeks after an 8 mg dose, with continued weight loss and difficulty eating enough. Explanations center on the drug's roughly five-day half-life causing accumulation, so residual levels still suppress appetite. Several describe planning to wait for food noise to return before lowering the dose or to eat more deliberately at the current level rather than reduce medication. Others note similar sticky effects and prefer keeping a steady dose while increasing calories to avoid under-eating.

What this discussion establishes

Nothing here is advice.

9 replies · 7 people
RustLantern55archiveopening postSep 30

My most recent tirz injection was on September 15 at 8 mg. I'm not ready to stop completely but want slower weight loss and a lower dose. Rather than sticking to a fixed schedule, I'm waiting until food noise and strong hunger come back, then trying 5 mg to see how it feels. Two weeks later it still feels like I just took a dose yesterday, with full control over appetite and hunger. I keep struggling to eat enough and want more food for my energy levels, yet weight keeps coming off. I'm aiming for a very small deficit of maybe one or two pounds a month. This seems unusual compared with what I've seen except for one other account. Previously I would notice food noise around day five, so I tried splitting doses, then relaxed the schedule to every seven or eight days as I neared maintenance. I've lost thirty percent of my starting body weight since February.

SteadySparrow75archiveSep 30

I'm at goal now and the last few weeks the scale has slowed to about half a pound to one pound per week. My plan is to stay on 5 mg tirz split plus 5 mg of the other compound and simply eat more, which I've started doing. I was barely losing when intake was low. I want to see what happens to weight when calories go up at the same dose. I don't know the right approach, but keeping the medication effects in place while adding food feels safer to me than easing off the medication and risking rapid regain.

GreenTimber59archiveSep 30

Remember the half-life and how the compound builds up. It has about a five-day half-life, so after fourteen days there is still some left from earlier doses that adds to the appetite suppression. I would lower to 5 mg and plan meals in advance to work around the reduced appetite while adjusting to the new metabolic rate.

SteadyMeadow42archiveSep 30

Maybe it's similar to muscle memory and the body keeps doing what it learned before. Being able to eat at maintenance without regaining would be ideal for most people.

BlueAnchor59archiveSep 30

That matches what I've seen. Staying on the medication means the appetite control stays strong and doesn't disappear right after missing a week. Waiting for actual food noise before moving to 5 mg for maintenance makes sense, but don't let under-eating continue too long in the meantime. Getting enough protein and doing some training can help avoid feeling drained.

LevelThistle44archiveSep 30
↳ replying to @RustLantern55 (opening post)

I took time off the other compound once I reached 200 lb to check appetite response and give my system a break. The same thing happened: dropping from 20 mg per week down to 8 mg produced no rebound hunger. I restarted at 8 mg and later returned to 20 mg along with 2.5 mg tirz and 1 mg of another medication. Sleep got better and I felt more relaxed, which makes me look forward to maintenance in another ten pounds or so.

PatientAlder89archiveSep 30
↳ replying to @RustLantern55 (opening post)

Maybe just pause and stay off until the food noise comes back so you can get used to eating a little more.

PatientAlder89archiveSep 30
↳ replying to @SteadySparrow75

Was the drop slower back when your food intake stayed really low?

SteadySparrow75archiveSep 30
↳ replying to @PatientAlder89

No, my food and calorie intake stayed about the same as I approached goal weight. The issue near goal is that there's less fat left to lose, so the scale moves slower, and because you're now a smaller person the same half-pound loss represents a bigger percentage change than it did at a higher starting weight. Since the current intake isn't producing much loss anymore, I'm going to increase food rather than lower the medication. I can eat more and a wider variety of things at these doses, I just haven't felt like it yet, but I will. Keeping the same medication effects as a steady base feels better than letting that base drop away.

PatientAlder89archiveOct 1
↳ replying to @SteadySparrow75

I thought you meant eating less had slowed your loss, ha. That might be what's happening with me too. I'm still about seventeen or eighteen pounds from goal but progress has been very slow. Most people increase the dose to lose more, yet I can barely eat already so I lowered it a bit and lost one pound. It's great that you can eat more now. After a few bites I feel full and don't want anything else. Glad you're at goal and can stay there. Have you tried lowering the dose further? Does that cause any gain or increase hunger? Hope you find the right maintenance level.

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