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What dose of tirz are you on?

11 replies12 peopleOct 27, 2026☆ Follow
Summary

What tirzepatide doses are people actually using and when should you increase if stalled?

Users report doses from 2 mg up to 20 mg weekly, with some stacking other compounds. Several have gone past the 15 mg labeled maximum without major issues, though effects often plateau. A stall after 10 lb loss at 12.5 mg is viewed as common; most advise checking food intake and protein first before raising the dose. A few note they are low or high responders and adjust accordingly.

What this discussion establishesWhere people disagree

Whether exceeding the labeled maximum is acceptable or should be avoided in favor of tightening diet first.

Still open

How much extra weight loss higher doses actually deliver once past 15 mg.

Nothing here is advice.

11 replies · 12 people
PlainBeacon63archiveopening postOct 27

I'm using 12.5 mg and it is working, yet I still need to drop another 15 pounds or more. After the first 10 pounds the scale has stopped moving. Is 15 mg viewed as a high amount? Are others going above that? I'm considering moving up to 15 mg.

IronSignal25archiveOct 27

I take 20 mg once a week, sometimes every five days instead. I respond slowly. Adding another compound helped with appetite control only for the first week; at 3 mg of that compound there is no suppression left.

BlueWillow74archiveOct 27

I just use whatever amount I need at the time. Last Thursday 7.5 mg did not do much, so Sunday morning I took 11.25 mg and have felt satisfied since with no side effects. I hope it lasts through the week. Best to pay attention to how your body feels and increase if there are no problems.

BlueAnchor59archiveOct 27

15 mg is listed as the highest amount on the label, so that is the official limit and increases usually happen by 2.5 mg every four weeks. Some here go higher, but that is outside the standard guidance and depends on personal results. A stall at 12.5 mg with 15 lb remaining is common, so tightening food records and protein intake for a few weeks makes sense before raising the dose.

BrightMeadow24archiveOct 27

I am at 10 mg and have been increasing since March. Yes, 15 mg counts as high and was the top amount tested. The number on the vial is only part of it though. What is your calorie deficit and exercise plan like?

PatientBeacon63archiveOct 27

I lowered to 2 mg because I respond strongly and kept losing past my goal even at 2.5 mg. Still working out the right level for me.

GreyLantern71archiveOct 28

How long have you stayed at 12.5 mg? 15 mg was tested in the studies. Right now I am on 10 mg and combining it with two other compounds.

NorthWillow72archiveOct 28
↳ replying to @PlainBeacon63 (opening post)

The top end on the label is 15 mg and studies are looking at 25 mg. I have used 15 mg for over a year and have been maintaining, though I tried dropping recently and might return to it. Others here take much higher amounts, some with stacks, and the highest I have seen is 80 mg a week. If you are stalled and struggling with hunger I would not hesitate to go up. Checking food choices can also help, since you can fill up on low-calorie items. You may be someone who needs an extra compound to target a different pathway. Your numbers show only about 12 lb lost so far, which is on the lower side.

CopperPebble16archiveOct 28

If the company had not been worried about future products they would probably have released larger amounts already, similar to how another maker went to a much higher dose. They tested bigger amounts internally but kept trials at 15 mg. I do not usually like going outside the tested range, yet reports of people reaching 30 mg and the other megadoses suggest 25 mg is likely safe. Just like with the other medication, the added benefit shrinks as the dose climbs, so another 10 mg probably will not triple the results but should still help.

SteadySparrow75archiveOct 28
↳ replying to @BlueAnchor59

Those dose numbers were just the points chosen for the approval studies. They could have picked different steps and a different top amount and people would treat those as the only correct ones. Once approval happened the studies were done, so finding the amount that works for you is not really outside the rules.

SharpCinder22archiveOct 28

Have you considered breaking up the weekly amount so you take it twice? I'm using 12.5 too and still have a comparable amount to shed. Going with two shots of 6.25 has given me smoother results all week long. It lines up with the five-day half life for tirz. Give that a go!

IronKettle44archiveOct 28

Big fan of Futurama!

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