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Sema to Tirz to Reta dosing

16 replies7 peopleOct 31, 2026☆ Follow
Summary

How to dose or stack reta after stalling on sema then tirz, including starting amounts and timing

Users who stalled on sema after substantial loss moved to tirz at 7.5 mg with limited effect and considered either raising tirz or switching to reta. Several report success by adding low-dose reta (1.5-3 mg) spaced 3-4 days from tirz rather than replacing it, sometimes adding tiny sema as well. This approach reportedly delivers benefits from all three with fewer sides while reaching goal weight. People space injections to align peaks and troughs and adjust based on personal response.

What this discussion establishesStill open

Exact starting reta dose after 7.5 mg tirz and whether three-way stacking is sustainable long-term

Nothing here is advice.

16 replies · 7 people
ClearCompass72archiveopening postOct 31

Hi everyone. I used sema for nearly a year and dropped just under 30 kg before stalling, then switched to tirz and reached 7.5 mg without much effect now. I'm weighing whether to go up to 10 mg tirz or try reta instead. Can anyone share starting doses, experiences, or advice on moving to reta after that kind of glp-1 history and similar switches?

BrightSparrow36archiveOct 31
↳ replying to @ClearCompass72 (opening post)

Think about a third choice: add reta on top of 10 mg tirz. For example take 2 mg reta three days before or after the tirz shot.

ClearCompass72archiveOct 31

I could look at that too. Have you done it yourself?

SteadySparrow75archiveOct 31
↳ replying to @BrightSparrow36

That is the route I would take or already took, with tirz on Monday, reta on Thursday and sema on Saturday.

BrightSparrow36archiveOct 31
↳ replying to @ClearCompass72

I began tirz at the end of January this year and added reta around April. I brought in sema about eight weeks ago. Right now I am on 10 mg tirz, 3 mg reta and 0.25 mg sema. I have lost around 80 lbs since mid-February. Stacking has worked well for me and I feel I get the upsides of all three without the downsides.

ClearCompass72archiveOct 31

Not sure three would work for me. I am about to get supplies and think I will try the tirz plus reta combination.

IronCinder88archiveOct 31

I have been stacking too and reached my target of 135 lbs. I am 46 and 5 foot 7, started from 275. The final 10 lbs were stubborn and higher tirz caused more constipation, so I added reta and hit goal within a month. I use 1.5 mg reta and 5 mg tirz spaced across the week and occasionally add a bit of sema when hunger returns. It gives the benefits without major sides.

NorthWillow72archiveOct 31
↳ replying to @IronCinder88

Nice result and I like the day name too.

ClearCompass72archiveOct 31

I have decided to try it. I normally do tirz on Friday so would you suggest reta on Sunday or Monday?

NorthWillow72archiveOct 31
↳ replying to @ClearCompass72

Most people wait three or four days after the other glp-1 so the new one peaks when the first is at trough. Four days lines up the reta peak with the tirz trough, though three days can be tried if you want stronger satiety coverage.

IronCinder88archiveNov 1
↳ replying to @ClearCompass72

I would leave three or four days between them to use the different half-lives, so with tirz on Friday that would put reta on Monday or Tuesday.

SlowLedger99archiveNov 1

When you end up with shots scheduled on separate days, set up alerts you will not overlook. I added notifications for this exact reason in my planning tool because mixing up which day is which happens easily.

PlainAlder11archiveNov 1

I might need to add some Sema for my wife if this Tirz does not start working. Her fourth 2.5 mg dose lands on Tuesday. I will check her weight Tuesday or Wednesday morning if possible. Any thoughts on moving her up to 5 mg? She takes 10 mg Reta on Fridays.

BrightSparrow36archiveNov 1
↳ replying to @PlainAlder11

If she has not had any sides so far then moving to 5 mg tirz looks fine to me.

SlowLedger99archive6d

going with the injection area that hurts the least still counts as a method, funny enough. half the point behind creating the pep planner was managing site changes since remembering it all myself was never realistic

↳ replying to @SlowLedger99

haha so you're really not dropping this are you...."what i'm getting from you is" validating the point...."your no-plan approach counts as a plan" flipping the whole idea with a question...."fine i'm done listening la la la la la!!" fingers in ears after turning a win into a loss just like i do with the usual crowd at home.... 😳 😬😲 😎

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