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Tirz not working after upping the dose

10 replies9 peopleNov 4, 2026☆ Follow
Summary

Why has tirzepatide stopped suppressing hunger and stalling weight loss after dose increases, and what should be done next?

The original poster lost 16 pounds early on tirz but saw diminishing hunger control and a stall after reaching 10 mg despite further increases and split dosing. Multiple replies note that stalls are common after initial rapid loss as the body adapts, and suggest holding the current dose while checking calories, protein, and activity rather than immediately escalating. Some users report that food noise levels off over time but the medication is still working, while others describe success by adding a second compound or eventually raising the dose higher after a plateau.

What this discussion establishesWhere people disagree

Whether to add a second compound now, wait longer at 10 mg, or titrate higher first.

Still open

How long to remain at 10 mg before any change and whether stacking or dose escalation works better for this stall.

Nothing here is advice.

10 replies · 9 people
WryBeacon95archiveopening post4d

Seeking opinions on my situation. For five months now I've used tirz. The first two months at 2.5mg it worked great, no food noise, and I dropped 16 pounds. Then at 5mg it helped for a month after noise returned. When noise came back again I increased to 7.5mg next month, but the appetite control wasn't as strong as before. Splitting the dose didn't change anything, weight stayed put and noise returned. At 10mg it's the same story. Scale isn't moving and hunger isn't suppressed like early on. I'm still carrying about 21 extra pounds. Should I try 12.5mg next, hold at 10mg longer, switch to reta, or add something?

Plateaus show up regularly when heading toward a target weight. The system pushes back hard against shedding each extra bit of mass. Once I'd dropped around half of what I planned to lose, everything slowed down inside to hang onto the remaining amount. I tried cutting back on what I ate each day or doing extra movement like longer walks, riding a bike or using the stair machine to use up more. Taking a higher amount of the medication didn't always change things, from what I noticed myself.

IronKettle95archive4d

I'm sticking with my current level of the main medication and looking at adding one of those other compounds on its own schedule, spaced out by several days. I'll increase the new one gradually once a month has passed if it seems right. No need to rush those adjustments. I also consider how much hunger signal is present. Certain folks aim to get rid of every bit of that feeling instead of just handling it. Being a bit hungry means some signal makes sense.

BlueAnchor59archive4d

Plateaus tend to show up with this med after the first quick drops start slowing down. Raising the amount at every pause on the scale usually just uses up the options faster without sorting out what goes in each day. I stuck with hitting protein goals, eyeballing overall calories, and getting in some walks while holding at the current level for multiple weeks before thinking about any change. Later increases seemed to work better spaced about a month apart. Trying combinations or different options came up as its own topic to sort with the doctor, not something to handle a stall right away.

Which one did you try, the real deal or the copy? For the copy, was there any lab work done on it? How can you tell it's not just water going in?

LevelAlder29archive4d

After dropping my initial thirty pounds around the four-month mark, I experienced a plateau lasting two months. Weight reduction doesn't happen steadily, since the body sometimes clings to mass following sudden large losses. I agree with the suggestions mentioned earlier about remaining at ten milligrams while verifying routines, and should the number on the scale stay put, one option is raising the amount gradually in smaller increments or combining treatments. For myself, combining seems preferable to changing medications entirely, and it also aids in gradually reducing the first one during a transition.

WarmKettle35archive4d

I began with Sema before switching over to Triz. Roughly two months have passed since I quit the second one entirely. Most of the weight came off during the first medication because the side effects were intense. I kept using Triz for more than a year even though I assumed it did nothing at all. Now that nothing is in my system the pounds have started returning and the urge to eat feels far stronger than I ever noticed before. Looking back the appetite control must have been holding steady without me realizing it. Holding at that same dose a bit longer seems like it could have made a difference.

BlueAlder13archive4d

I felt worried about getting hungry so I tried adding those two. My system seemed convinced that food was hard to find. It might seem odd yet eating more for a while made things easier for me.

WarmAnchor55archive4d
↳ replying to @WryBeacon95 (opening post)

My situation lined up with that description in every way. For a while I kept my tirzepatide at ten milligrams weekly because I felt uneasy about raising it. Later I began mixing in semaglutide and built that up to one milligram each week. Even so my weight refused to move either direction across several months. At last I stopped hesitating and increased the tirzepatide to fourteen milligrams and immediately the effect matched my earliest days on it. Cravings disappeared and hunger stayed very low. A couple pounds came off within the first week after the increase. I have no idea what comes next yet feel relieved the plateau finally ended.

WarmKettle35archive4d
↳ replying to @BlueAlder13

Folks have mentioned combining Triz and Reta, yet I've not come across Sema paired with Triz. I'd be open to giving that mix a shot myself.

WryBeacon95archive4d

Thanks for the replies. Just to answer a few questions, the batch was tested and it's the same one I've been using the whole time. I'm not trying to get rid of food noise completely, just keep the snacking manageable the way it was during the first few months. That's my main issue right now. Protein and diet are otherwise fine, but I'll track my protein and calories a bit more closely. I'll stay on 10mg for another month, focus on tightening protein intake to help with the snacking and food noise, and see how things go after that.

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