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Weight Gain, and new plan. Looking for ideas and stories.

20 replies13 peopleAug 14, 2026☆ Follow
Summary

How to combine high-dose tirzepatide with low-dose retatrutide to resume weight loss after regaining on tirz alone while avoiding anhedonia

The original poster regained weight after switching back to tirzepatide due to anhedonia on retatrutide and is considering 15 mg+ tirzepatide plus 1-2 mg retatrutide weekly. Several users report success with similar low-dose retatrutide additions to tirzepatide for breaking stalls or boosting metabolism without full side effects. Others note that shot timing can help cover weekends and that weekly calorie averages matter more than daily ones. High tirzepatide doses above 15 mg are mentioned with mixed results and some users prefer adding different agonists instead.

What this discussion establishesWhere people disagree

Whether further diet and exercise optimization can still move the needle versus relying primarily on GLP-1 adjustments

Still open

Whether the proposed high-tirzepatide plus very-low-retatrutide stack will actually produce additional loss for this user

Nothing here is advice.

20 replies · 13 people
AmberCompass26archiveopening postAug 14

Been using these meds for years. Started on one and dropped from 270 to 220, then switched to the other and lost about ten more. Never quite reached the 190s though. Later had to drop the second one because it left me feeling flat and unmotivated, which isn't like me, and I put some of the weight back on. Now sitting around 225-230 on 10 mg of the first one. Thinking about going higher on that and adding just a tiny bit of the second one to see if I can move again without the flat feeling returning.

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LevelThistle44archiveAug 14

What were the highest amounts you reached with each one?

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AmberCompass26archiveAug 14
↳ replying to @LevelThistle44

I reached the top levels for both at different times, though not for very long stretches.

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ClearBeacon24archiveAug 14
↳ replying to @AmberCompass26 (opening post)

Been running 8 mg of one and 7 mg of the other for over a year and it works for me, though results vary.

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GreyHarbour88archiveAug 14
↳ replying to @AmberCompass26 (opening post)

I added the second one on top of the first to get past a stall without ever stopping the first. The mix helped. Now on 10 mg of the second for months and starting to notice the flat feeling again, which is worse than it sounds. Hoping to find a maintenance balance soon.

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NorthLantern91archiveAug 14

Outside the meds, how are calories, protein, training, and sleep looking? Improving any of those could make a big difference.

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AmberCompass26archiveAug 14
↳ replying to @NorthLantern91

I hike four miles three or four times a week plus some light lifting. Eating is solid during the week but looser on weekends because of plans. The meds helped a lot with appetite early on but now it's just normal. I've heard the diet and training talk plenty of times and nothing else has matched what these meds do. Still, my real questions are whether going past 15 mg on the first one helps and whether tiny amounts of the second one add anything useful.

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NorthLantern91archiveAug 14
↳ replying to @AmberCompass26

Fair enough. Those basic checks are like tech support asking if you rebooted.

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BrightSparrow36archiveAug 14

Try the loseit app set to sedentary and don't eat back exercise calories. Food intake matters most.

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LevelSignal57archiveAug 14

The flat feeling is definitely real. I started seeking out threesomes again just to get some dopamine back.

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NorthWillow72archiveAug 14
↳ replying to @AmberCompass26

Weekly average deficit matters more than day-to-day. Aim for about 3500 below maintenance per week to drop a pound. These meds can be overridden if you keep eating anyway. Higher doses of the first one have shown some extra effect in trials up to 25 mg, though returns diminish. Adding a bit of the second one brings in the third receptor pathway that increases energy burn and fat breakdown.

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ClearBramble68archiveAug 14
↳ replying to @AmberCompass26

What day do you inject? Shifting to Thursday might line up better appetite control with the weekend when plans tend to happen.

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ClearBramble68archiveAug 14

Some people are running well above 15 mg weekly and reporting on it in another thread. One update mentioned trying 20-25 mg every two days along with small amounts of other similar compounds at different times.

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NorthWillow72archiveAug 14
↳ replying to @ClearBramble68

Good idea. I picked Wednesday on purpose so days six and seven fall on Monday and Tuesday.

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AmberCompass26archiveAug 14
↳ replying to @GreyHarbour88

The flat feeling is genuinely rough and gave me more understanding for people dealing with actual depression. I couldn't handle it long term. It hit both times I tried the second med and seems to start above 6 mg weekly for me, so I'm hoping a small blend keeps it away. My diet and training aren't perfect either, which is why I'm still looking at these options.

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AmberCompass26archiveAug 14
↳ replying to @ClearBramble68

I saw that thread before joining. Not really worried about safety with the first med since it has agreed with me so far, aside from some tiredness the next day. Sixty milligrams a week is quite a run though.

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BrightSignal52archiveAug 14
↳ replying to @AmberCompass26 (opening post)

Doing 13.2 mg of the first on Mondays and 3 mg of the second on Thursdays. The small second dose keeps metabolism up without the earlier sides like higher heart rate or skin sensitivity. Tried each alone and prefer the first but wanted the extra burn from the second. Three milligrams seems to be the right amount now and I'm planning to go up to 15 mg on the first soon.

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PlainTimber88archiveAug 19
↳ replying to @BrightSignal52

Do you take the 3 mg of the second every seven days?

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CopperSignal27archiveAug 20

From 270 down to around 230 on 10 mg is about average progress. Not sure why you're staying at 10 mg instead of trying 15 if more loss is the goal. Adding the second one after the first might not get you all the way to 190. Higher doses of the first show diminishing returns, so something that works on different pathways could be worth testing instead.

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BrightSignal52archiveAug 20
↳ replying to @PlainTimber88

Yes, 3 mg of the second every Thursday morning.

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CopperQuill49archiveAug 20

I'm in a similar spot and just started adding another compound to the first one. Feeling hopeful about it.

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