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Time from pinning to noticing symptoms/results?

10 replies7 peopleOct 27, 2026☆ Follow
Summary

How long after injecting Tirzepatide or Retatrutide do appetite suppression, nausea, and alcohol craving reduction typically start?

Users report Tirz effects on hunger and cravings often appearing the day after injection, sometimes with nausea, while Reta symptoms can lag 48-72 hours and full benefits may take up to two weeks. Personal stacking experiences vary, with some noting alcohol disinterest at 2 mg weekly Reta doses even after lowering for side effects. Trial data on peak timing curves is not referenced; responses stay anecdotal.

What this discussion establishesStill open

Whether measured pharmacokinetic curves from trials show consistent peak timing for these peptides

Nothing here is advice.

10 replies · 7 people
WarmBramble71archiveopening postOct 27

Hi, total beginner here. A few weeks back I began at half a milligram of Reta, then moved to one milligram. I added Tirz on top because it is said to control food and especially alcohol urges more strongly. Yesterday morning I injected two point five milligrams of Tirz, probably should have begun lower. Nothing much happened that day, maybe slight hunger drop but I drank normally. Today though I have no interest in eating or drinking at all, plus a touch of nausea where food just turns me off. This matches what another forum member described about Tirz hitting hardest the second day. Does anyone have actual numbers on how long after an injection these compounds reach their strongest point? Trial results or just personal stories would help.

RustPebble88archiveOct 27

For Tirz I notice effects and side effects around twenty four hours later. With Reta it is forty eight to seventy two hours until symptoms show, though real benefits take about two weeks. I usually inject once every seven days or do a three day on four day off schedule for steadier results, like Sunday and Wednesday. Experiment to see what schedule suits you.

AmberBeacon57archiveOct 27

On its own Reta took away my urge to drink. It was roughly a week before I realized the craving had disappeared.

WarmBramble71archiveOct 27
↳ replying to @AmberBeacon57

That effect has not shown up for me yet, though maybe one milligram is still too low. At what weekly amount of Reta did you see the alcohol craving change?

WryLedger77archiveOct 27
↳ replying to @AmberBeacon57

I had the same experience. Around the two milligram per week level that alcohol related change became noticeable for me.

AmberBeacon57archiveOct 27
↳ replying to @WarmBramble71

The change appeared once I reached two milligrams weekly. I later dropped to one point seven five milligrams to ease stomach fullness and constipation, yet the lack of interest in alcohol remains.

WarmBramble71archiveOct 27

Good to hear those reports. Still wondering whether any trial data exists on the time course of effects for Tirz or Reta after an injection.

PlainAlder11archiveOct 28

Results vary widely between people. My partner and I both noticed appetite suppression by the next evening after starting two milligrams of Reta. She recently added two point five milligrams of Tirz on Tuesdays plus ten milligrams of Reta on Fridays and finds the combination effective.

IronKettle95archiveOct 28

Beginning with the standard initial amount is perfectly okay. A few folks go smaller at first, but that wasn't my approach. Tirzepatide becomes noticeable to me six hours after the injection and reaches its peak by the twenty-four-hour mark. I would have raised the Reta level to a proper therapeutic amount or tried Tirzepatide on its own before combining anything. Build one compound up to a meaningful level before introducing extra factors. Once a dose is chosen for either compound, hold it steady across four weeks before reviewing progress. There's no reason to hurry. Getting the amount of medication stable in your system has to happen first so any later tweaks can be judged accurately.

NorthWillow72archiveOct 28

I responded quickly, yet stayed very disciplined too. During my initial four weeks

WarmBramble71archiveOct 28
↳ replying to @IronKettle95

Yeah I see the point... though sometimes urgency pushes you into doing things anyway. I can't recall going even two evenings without a drink until recently. So I don't really regret the choice. Still, I'll stick with this plan for at least four weeks and then decide what comes next based on how things develop. Thanks everyone!

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