Several users report breaking stalls after moving from tirzepatide to retatrutide, with steady losses of 1-1.8% body weight per week once reta reaches effective levels around 5-8 mg. Some combine low-dose tirz with reta or add cagri for appetite control, while others note walking helps avoid metabolic slowdown. Concerns about stacking, fibrils, and long-term safety lead some to prefer single agents or view surgery as last resort.
What this discussion establishesWhether mixing multiple GLP-1 agonists or adding cagri is advisable versus staying on one compound.
Still openWhether reta alone will allow the original poster to lose the remaining 100 pounds without surgery.
Nothing here is advice.
Been on tirzepatide close to ten months and lost sixty pounds, but hit a stall the past few months. Hoping reta will get things moving again, though still worried with another hundred pounds left to go. Started tirz at 339.3 pounds. Anyone else stalled at a high tirz dose who then switched to reta and kept dropping a lot of weight?
What dose are you on right now and how long has the stall lasted?
On 12.5 mg and stalled almost two months. Planning to start reta this week once the package arrives.
Look around the forum. Not as far into this as you, but I was at 5 mg weekly of tirz and moved over to reta fairly fast, averaging about one percent of starting weight lost each week.
I hit stalls on tirz a couple times too, one lasting seven or eight weeks. These pauses happen. I kept going, raised the dose, and reached goal on 15 mg.
Started at 330, now at 252 after five months plus. Fast one day a week until a pound or two comes off. Currently on 7 mg tirz and 5 mg reta, split across days.
How are you titrating? One 12.5 mg pen left, so thinking 2 mg reta for two weeks then 4 mg for two weeks while finishing the pen, then 6 mg reta alone. Heard most switching from high tirz need around 8 mg before suppression feels solid.
I do 7 mg tirz Friday morning and 5 mg reta Monday morning. Since combining them the weight has come off fast and I haven't needed to raise doses. Same total dose you're considering, just split between the two. Lower doses aren't cutting food noise for you, which is rough. Dose whatever actually works; cagri plus reta gets mentioned for appetite too.
8 mg reta works great for me, strongest appetite control yet. Was on 10 mg tirz split before, which was fine until anhedonia showed up. Now stacking 2 mg cagri Monday and 8 mg reta Thursday, steady 1-1.5 kg loss weekly. Might swap cagri for sema since it's cheaper and cagri hasn't been as strong as expected for me.
On 1/10 tirz level was about 4.9 mg. Started adding 1 mg reta that day and the next, then another 1 mg, later 2.5 mg tirz, and kept adjusting reta up while tirz dropped. Now at roughly 2.7 mg tirz and 5.3 mg reta. Weight down from 272 to 266-267. Added magnesium, cut fiber supplement. Main side is feeling cold more, which is fine. Heart rate variability flat to slightly up, resting heart rate down 5 bpm. Appetite and food noise both flat. Planning another 3 mg reta soon to reach 5.8 mg peak.
What's your age, height, starting weight and current weight? Worth trying, but avoid mixing lots of different drugs. Start with one weekly peptide dose. I switched cold turkey from tirz to reta and it seems to burn more fat with noticeably more energy.
Stacking glp-1s has mixed reports so I wanted to avoid long term. Still, the chance of stalling on reta because of high mounjaro doses worries me; seems common in threads. Either this works or surgery is next.
Don't hesitate to go above standard doses; trials are testing higher amounts like 8 mg sema or 25 mg tirz, so glp-1s look safer than once thought. Gastric bypass carries more risk and horror stories, so treat it as last option.
Heard good things about cagri and even ordered some with the reta as backup. Threads about fibrils and oligomers made me back off completely though.
My appetite came back yesterday at roughly the same hour, nothing intense but definitely noticeable. I ate a brownie since I needed some carbs and that kept the feeling away for hours before it returned. This matched what happened the prior week. So I went with 2.5mg Reta plus 2mg Tirz yesterday, which puts my Reta high point at 5.7mg after a 0.3mg bump from the earlier peak on 1/19 while Tirz sits at 3.6mg after dropping 1mg from its prior peak on 1/15.
That reply isn't reassuring at all, since dementia and possible organ damage aren't things I want to experience.
If that's how you feel, what brings you to this kind of place? Clearly all the material gets created in a dirty tub close to the nearby whorehouse, right?
People vary in how much uncertainty they can handle. Although these come from unofficial channels, some level of checking happens. The group here is helpful, and the known effects of this class of drugs are documented. Honestly, I might experiment with adding something else down the line should the present choice fall short, yet right now I'm not entirely at ease taking that step.
That one cuts food consumption by boosting fullness messages and making servings smaller. Haven't the two similar drugs already lowered your hunger enough in practice? This new addition includes glucagon action, potentially lifting your resting metabolism around five to ten percent and supplying a mechanism missing so far. Have you been logging what you eat in calories? Have you been active and recording those efforts? Avoiding food altogether might cause your metabolism to adapt by slowing down the baseline, resulting in a plateau.
My main challenge has come from food choices because they represent my biggest difficulty and the reason my weight climbed past three hundred sixty pounds. I quit going to the fitness center after September.
Simple daily strolls rarely get credit for burning energy and boosting heart function while going easy on the knees and hips. My routine kicked off early in January aiming to use up five hundred calories daily just from those steps. This is now my twenty first straight day, adding up to three weeks total. During that span my weight fell four point four percent from the start, averaging one point one percent each week. I moved over to Reta late on the tenth, and from there the drop reached three point three percent across thirteen days or about one point eight percent weekly. Before adding walks, beginning mid December on Tirz I saw a two point eight percent reduction across twenty two days up to when the steps began, coming to zero point nine percent per week. The activity and the medication both show real strength.
If you have tried it, this topic is still open. Sign in to reply — it takes a minute.