ForumDosing & Titration

Tesa reconstitution from 10mg vials, dosing, timing, and user experiences with related peptides

10 replies6 peopleMar 24, 2026☆ Follow
Summary

How should someone reconstitute and dose Tesa from 10mg vials, what timing works, and what results or IGF-1 changes do users report when stacking with other peptides?

Users describe mixing 10mg Tesa vials and running 5x2 or daily schedules at 1-2mg doses, often at night fasted or in the morning. Several report improved sleep, recovery, and energy after switching from other secretagogues, while tracking IGF-1 levels that rose substantially in one case from 165 to 401. SS-31 is noted as a useful precursor to Mots-c at 5mg daily for 60 days. Bloodwork before starting is repeatedly advised, especially for those under 40.

What this discussion establishesWhere people disagree

Whether Tesa is advisable when baseline IGF-1 already sits near or above typical ranges; some see no need while others experiment with short cycles and monitor z-scores.

Still open

Long-term safety of pushing IGF-1 above 400 and the ideal duration or cycling protocol for Tesa remain open.

Nothing here is advice.

10 replies · 6 people
PatientSignal25archiveopening postMar 24

Hello everyone with experience here. Thinking about adding Tesa to what I'm already using and would appreciate input on a few details. For the 10mg vial, is mixing it with 1ml of bac water the standard approach? How much should the dose be? Which part of the day works best for the shots? Already taking 2.5mg reta and 10mg KLOW while planning to begin ss31 ahead of Mots C. Thanks for any replies.

WryQuill58archiveMar 24

Using SS31 ahead of mots-c lines up well and should support the later results. Same here with Tesa on a 5x2 pattern at 2mg each night, three hours after eating, for nearly three months now and the effects have been strong. Switched over after a month on cjc/ipa because of sides. Sleep, recovery, energy, and muscle tone all improved. Under 40 the secretagogues tend to give limited returns. Checking igf-1 via bloodwork first is always smart before beginning.

PatientSignal25archiveMar 24
↳ replying to @WryQuill58

Blood panel already completed and results are pending. Same view on running SS31 first. What amount of SS31 did you use? Looking forward to trying Tesa, especially at 38 with diet and training dialed in after dropping weight and getting leaner. These peptides that support further progress seem worth adding. Keeping reta steady at the current level for the next six months since it manages food noise without issues. KLOW went in mainly for joint comfort, with only minor changes in bloating noticed so far, possibly from the KPV component. Thanks for the reply and any further thoughts.

WryQuill58archiveMar 24

Stayed with 5mg daily on the same 5x2 pattern for a full 60 days before moving to MC at 2mg each morning while fasted ahead of training. GHK and a low dose of BPC go in at the same time but with separate injections. Looks like a steady approach overall.

PatientSignal25archiveMar 24
↳ replying to @WryQuill58

Sounds good, we'll see how it goes and thanks again for the details.

GreyBramble68archiveApr 21
↳ replying to @PatientSignal25 (opening post)

For anyone running Tesa with or without IPA, what were the igf1 numbers and z-score before and after? I already have the Tesa on hand but the latest test showed 363 with a z-score of 1.9, which makes me hesitant since it could push past 400. Curious what levels others reached while using it.

QuietFenwick11archiveApr 21
↳ replying to @GreyBramble68

In that case Tesa probably isn't necessary.

GreyBramble68archiveApr 21
↳ replying to @QuietFenwick11

Correction, the actual reading was 323. Still interested in whether others have taken igf above 400 during a cycle and what fat-loss outcomes followed.

QuietFenwick11archiveApr 21
↳ replying to @GreyBramble68

Direct comparisons across individuals don't hold much value because baseline igf varies with age and sex. The z-score is the better reference point, and keeping it under +2 is generally viewed as lower risk. Crossing that line for extended periods raises chances of left ventricular hypertrophy, higher blood pressure, insulin resistance, and cancer concerns.

WarmHarbour52archiveApr 21

Just began TESA at .5 mg on the current schedule for the first two weeks before moving up to 1 mg while keeping the same pattern.

PlainWillow50archiveApr 21
↳ replying to @GreyBramble68

Used Tesa alone without IPA, beginning at 1mg daily then increasing to 1.5mg after roughly a month and later to 2mg around week ten or eleven. Labs on January 15 showed 165 with z-score .1; by March 16 it reached 401 with z-score 2.5. Dropped straight back to 1mg daily taken two to three hours after the evening meal and plan to recheck in June.

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