CommunityPlateaus & Non-Response

Feel like I've hit a tirz plateau. Switch to reta now or wait?

18 replies9 peopleOct 9, 2025☆ Follow
Summary

Should I switch from tirzepatide to retatrutide at a plateau near goal weight or increase the current dose first?

The original poster is near goal but stalled on 8-8.5 mg tirz and has prepared both compounds, leaning toward switching after finishing the current vial rather than stacking. Several replies advise raising tirz to 10 mg first since the user has not reached the upper limit and the process is long-term. Others note that stacking can work if doses are separated by days, while one user describes a gradual cross-taper that still allows continued loss. Concerns about receptor breaks and side-effect management appear but no consensus forms on the best timing.

What this discussion establishesWhere people disagree

Whether to finish the current tirz vial and switch immediately or stay on tirz and titrate higher first

Still open

How the original poster will respond to reta or whether the plateau would have broken at 10 mg tirz

Nothing here is advice.

18 replies · 9 people
RustBramble27archiveopening postOct 9, 2025

I've been using roughly 8 to 8.5 mg of tirz each week. I'm only a couple pounds from goal but the scale has stopped moving and even crept up a bit. This morning I reconstituted a vial of each compound and now I'm deciding what to do next. I could use up the tirz over the coming three or four weeks before trying reta, or switch at the next injection. What I've seen suggests avoiding a stack and waiting at least seven days after the last tirz before starting reta around 1 mg. Plenty of people here have experience with both, some stack without trouble while others caution against it. I'm leaning toward switching after the wait.

GreenFenwick10archiveOct 9, 2025

You have not reached the top end with tirz yet, so why change now? This takes time.

SharpPebble61archiveOct 9, 2025
↳ replying to @RustBramble27 (opening post)

Some combine the two for the different effects but keep the injections on separate days.

RustBramble27archiveOct 9, 2025

I figured it might be smarter to change before getting close to the maximum. I had read that switching peptides for a while can give the receptors a break. I wanted to stay below 10 mg tirz, let alone 15. Since this is a long process and I have not even been using these for a full year, that seemed reasonable.

SharpCinder28archiveOct 9, 2025

Two milligrams of reta works fine if you are headed to a pizza buffet.

RustBramble27archiveOct 9, 2025
↳ replying to @SharpCinder28

Do places still have those? I miss Cici's.

SharpCinder28archiveOct 9, 2025

Some Pizza Huts still offer them too. I have started combining reta because 2 mg alone is not doing much for me.

CopperCompass90archiveOct 9, 2025

I gave a thumbs-up because your plan to avoid stacking makes sense. I would also try raising the tirz dose once you confirm the stall. Think of it like a headache: do you take a child's dose, one adult dose, or two? Or if you want a certain effect, one shot or three? Give 10 mg tirz a few weeks and see.

SharpCinder28archiveOct 9, 2025

Exactly. Using reta has made me value tirz more and I plan to keep more of it on hand. At 6 mg and above reta might suit me better, but getting to that level has been rough. Higher tirz gave me GI issues before, yet I have found ways to handle them now, including kratom to head off diarrhea and imodium when needed.

WryCompass39archiveOct 9, 2025

My own experience has been to raise reta while lowering tirz because I did not want to lose as much muscle. Every two weeks I drop tirz by 1 mg and add 1 mg reta, and the weight is still coming off. Not sure if that approach would help here.

WryCompass39archiveOct 9, 2025

This week I moved from 8.5 mg tirz down to 7.5 mg and three days later took 2 mg reta. Next month the plan is 6.5 mg tirz with 3 mg reta, then we will check results.

SteadyQuill55archiveOct 9, 2025

Hold on. You mixed up a vial of each before even choosing which to use? Are you well off or am I just overly careful about not letting any go to waste when supplies feel limited?

AmberAnchor10archiveOct 10, 2025
↳ replying to @GreenFenwick10

That is what I would have said too. When I was still at 7.5 mg tirz it hardly worked and I gained a couple pounds. Once I moved up to 10 mg the loss started again and I stayed there for months.

SteadyQuill55archiveOct 10, 2025
↳ replying to @SharpCinder28

I would like to hear more about kratom and its addiction risk. Most things I have read make it sound quite risky, but I have seen enough of your other posts to think you would have considered that carefully.

SharpCinder28archiveOct 10, 2025

That risk is probably real for some people. I am too inconsistent to take most things regularly anyway except the GLPs. My main habits are digital. One extra benefit of kratom for me is that it can reduce appetite a little. It is also inexpensive. I ordered several strains totaling a thousand capsules for a modest amount including delivery. The label suggests four capsules per serving but many take more, as I do.

SteadyQuill55archiveOct 10, 2025
↳ replying to @SharpCinder28

Thanks, I appreciate you laying out your thinking. It reminds me of my mother, who simply is not prone to addiction. She had to use pain pills for nearly a year, disliked them, split doses to keep intake low, and saved extras because she knew they might be needed later when harder to obtain. She was very relieved to stop after her knee replacement. My father and I, on the other hand, both tend toward dependency, so the contrast stands out.

CopperLedger37archiveOct 10, 2025

You are only a few pounds from goal. Moving to a different medication might not be smooth. Stay with tirz and raise the dose a little if needed.

RustBramble27archiveOct 10, 2025

I will probably finish the new tirz vial, which should last about three weeks, then start the reta. I have had the reta for months and want to see how it works. The stall made this feel like a reasonable time to try it.

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