A single case study does not prove anything beyond that one instance. Many gut treatments help only some people some of the time and lack strong evidence. After trying roughly a dozen supplements and probiotics with little success, the biggest improvements came from losing weight, eating less overall, and following a low-fodmap diet. The underlying issue is ibs-d plus leftover symptoms from ulcerative colitis that is considered in remission, a situation affecting about forty percent of such patients with ongoing pain and tiredness.
An nih paper described gains in gut barrier function and tiredness after a two-strain bacillus probiotic taken twice daily for three months. Stopping the probiotic brought both issues back. Adding a medicinal clay product three times a day plus another probiotic course then kept permeability and fatigue lower for six months total. Clay was stopped after four months to avoid possible nutrient absorption problems. The poster is now using two separate single-strain probiotics twice daily plus food-grade bentonite clay in enteric capsules three times daily, aiming only at barrier repair. The chosen strains are said to work together to raise tight-junction proteins.