Finally pinning Tesamorelin and Ipamorelin

I use 2 mg tesa and 300 mcg ipa. Only one week in so nothing to report yet. Time will show the results but many people speak highly of the combination so I expect it will help with stubborn visceral fat.

My subject started the exact same combined doses on August 1 using 5 days on and 2 off along with 7.5 mg tirzepatide weekly after noticing muscle loss instead of stubborn visceral fat. Waist dropped from 44.5 to 40.375 inches by October 1 with no muscle loss and possibly some gain. Most of the change was visceral. No other fat was present in large amounts. No research supports the 5-on-2-off schedule but it appears to suit the subject. Tesamorelin data only covers certain HIV patients so no claim is made that it caused the change here. Whether the fat returns after the planned November break is still unknown.

Used a similar protocol for 8 weeks three times over the past two years. The main advice is not to worry about early water weight. Gained 4-7 pounds but it came off within a week after finishing and waist measurement was smaller afterward.

It started and then stopped quickly. Tesamorelin affects me the same way cjc does with ruined sleep and an itchy spot. Looks like I fall into that group of people. Have nine vials of tesamorelin and ipamorelin left if anyone wants them.

Took the first tesa ipa cjc dose last night. Slept very well for the first time in weeks. Had a slightly red itchy spot that lasted about 40 minutes. It is only a minor bother so far.

Picked up a lot of water weight on a similar protocol that settled in the feet and hands. It was bothersome but disappeared once the cycle ended. Not sure if I would repeat it and plan to look at other options first.

Was already fasted before the dose to avoid any issues with effectiveness or A1c. These growth-hormone secretagogues simply do not agree with me but I may try real hgh later.

I get an itch after the shot that lasts around 30 minutes and also notice the same water retention but that seems to be the tradeoff.

Second dose last night produced only minor itch for 20-30 minutes and sleep was again very good. Still too soon to judge other effects. Deciding whether to skip the weekend or keep going straight through.

Follow-up after deciding to continue through the weekend. Sleep remains better than before starting. Weight ticked up this morning so water retention may be beginning. Still get some itch and minor redness at the site. Tried a massage gun on the area and the itch disappeared in under a minute and did not return.

One week later and roughly ten days into the blend. The site reaction is now like a mosquito bite for about five minutes then gone. Sleep is still good. No water retention noticed. Heart-rate variability doubled at first then settled back about 10-15 percent. Mood has improved noticeably with far less grumpy reactions. Planning a 12-week cycle followed by four weeks off.

Stopped. These secretagogues are not for me. No problem though since I enjoy testing different compounds. Moving on to something else now.

Does the ipamorelin increase hunger? Tried mk677 before and it made me extremely hungry.

Yes anything that acts as a ghrelin agonist does that. Took it right before bed and would feel starving before falling asleep. Have not tried mk yet but everything read and heard indicates it drives hunger so one should watch portions.

Running both now at 2 mg tesamorelin and 1 mg ipamorelin twice daily upon waking and before sleep. Third week in and beginning to notice some effects along with water retention and fingertip tingling.

Do you mix them together or pin them separately?

Researching tesamorelin at the moment. Accidentally ordered a 1:1 blend and have not started it because reaching the proper tesamorelin dose would require six or seven times the ipamorelin amount. Planning 300 mcg ipamorelin at bedtime so ordered separate tesamorelin to pin 1.5 mg in the morning and the blend at night for a total of roughly 1.8 mg tesamorelin and 300 mcg ipamorelin daily. Considering whether to run Monday through Friday or every day.

Research showed most protocols are daily 2 mg at night on an empty stomach. Cycle lengths vary from 10-12 weeks up to six months with 8-10 week breaks between. Have enough for a bit over nine weeks so may start at 1 mg for two weeks then move to 2 mg for the remaining eight. Empty stomach or 90 minutes after the last meal is repeatedly advised.

Grok produced a clearer summary that matched the same findings. Main difference noted is that clinical trials often run longer cycles possibly because they target HIV patients. Tables are hard to format here but the overall pattern is readable.

Have you tried 30 mg of fexofenadine one hour before the shot?

Started 1.8 mg tesa with 300 mcg cjc ipa blend before bed two nights ago. Last two nights of sleep have been the best in a long time whether from the peptides or coincidence. Wake up rested and with energy.

Hoping the tesamorelin arrives soon. Looking for something to improve sleep since epithalon and selank have not helped yet.

Want to clarify that visceral fat sits under the muscle around the organs while the fat you can pinch is subcutaneous. The distinction matters for health risk and cannot be measured accurately with just a tape measure or basic scale.