ForumDosing & Titration

How to reconstitute HGH (somatropin) plus dosing protocol

9 replies6 peopleApr 28, 2026☆ Follow
Summary

How should a 24iu HGH vial be reconstituted with bac water and what dosing schedule is appropriate?

Users suggest starting with bloodwork to establish baseline IGF-1 and other markers before beginning. Common approaches include adding 1.2 ml or 2.4 ml bac water to the vial for easy measurement of 2 iu or 1 iu per 0.1 ml injection, taken daily at night. Several participants stress that noticeable effects require at least six months and that doses above 2 iu can push IGF-1 very high, so gradual increases and regular monitoring are advised.

What this discussion establishesWhere people disagree

One participant views 1.5 iu as already excessive for a 58-year-old while another argues that 4 iu is the level at which real benefits begin and that gray-market HGH may require higher dosing than pharma-grade.

Still open

Whether the user’s current Tesa protocol has affected IGF-1 levels and what exact starting dose is safest given the user’s age and other compounds.

Nothing here is advice.

9 replies · 6 people
PatientSignal25archiveopening postApr 28

Hey team, I’m about to start HGH from a 24 iu vial. Can anyone advise how much bac water to add and what dosage plus injection timing would be good? Thanks y’all.

PlainAnchor67archiveApr 28

Not knowing your aims around development I'll mention my own habit. Every night my dose comes to 2iu. For mixing I put in 1.2ml of bacteriostatic water so a 0.1ml amount equals 2iu.

LevelPebble75archiveApr 28

Checking blood levels first seems important because that guides how much to use. Started low at half a unit and increased gradually to two. That higher amount pushed my growth factor levels really high. Paused for a while to let things settle. Thinking about resuming at the lower dose soon. Getting tests done regularly every couple of months. Notice my hair growing much faster with this.

PatientSignal25archiveApr 28

Blood tests came back fine. Right now I'm taking half a milligram of TRT each week along with two point five milligrams of Reta weekly too. Also doing two milligrams of Klow following a five days on and two off schedule. Over the last thirty days I've been using one milligram of Tesa every night prior to sleeping yet haven't noticed any changes at all so I'm thinking about trying Soma instead.

PatientSignal25archiveApr 28
↳ replying to @PlainAnchor67

Thanks Champ. Do you inject daily then, before bedtime?

LevelPebble75archiveApr 28
↳ replying to @PatientSignal25

Has there been zero movement in your IGF-1 value throughout the entire time on Tesa?

CopperSignal27archiveApr 28

Before beginning anything I got my igf-1 level checked once the earlier peptide had cleared so the reading would reflect my normal state. I also confirmed that glucose hb1ac pressure and lipids sat in normal ranges. Any noticeable change from the peptide or growth hormone takes well over a month to show up. I looked into possible unwanted effects ahead of time to understand the downsides. How old someone is changes the picture younger people face more years of possible issues while older ones usually need smaller amounts. Short-term problems can include wrist pain and swelling while longer-term concerns involve bone overgrowth heart strain and maybe higher cancer odds especially with bigger amounts. Without knowing someone's age no amount can be guessed at. At fifty-eight I began with what seemed like a modest daily portion yet my level reached fifty nanomoles per liter against an expected twenty leaving it far above the usual range for my age. The numbers reported in different countries do not match so I paid attention to that. For a vial holding twenty-four units I mixed in two-point-four milliliters of bacteriostatic solution making each tenth of a milliliter equal one unit which kept the math straightforward.

IronAlder39archiveApr 28
↳ replying to @CopperSignal27

Why so worried? Lots of old assumptions about HGH have already been disproven. Do you know how much daily HGH a person with HIV takes to avoid unwanted muscle loss? 18 iu per day. The older you get the lower your IGF-1 level becomes; by age 50 it is only half what it was at 21. That is why HGH use fits better at later ages. 1.5 iu is fine for quicker hair growth and better nails. Around 4 iu is where it really starts to work. Raise the dose slowly to that level. Since the HGH was bought on the gray market you can comfortably use about 4 iu. Real pharma-grade HGH at 2 iu is comparable to 4 iu of gray-market product because mannitol and freeze-drying affect potency. Keep in mind HGH is not a one- or two-month thing; its real effects show after at least six months. It is true that active cancer cells can be stimulated by HGH, but high sugar does the same, so check blood markers beforehand.

SteadySparrow49archiveMay 21

I hope everyone will decide to post using English only.

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