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T3 and T4

33 replies11 peopleMay 21, 2026☆ Follow
Summary

Is it worth trying T3 or T4 thyroid medication for fat loss or recomp when levels sit in the upper normal range?

Most participants strongly advise against using thyroid meds without medical supervision and regular bloodwork, citing personal experiences with mood swings, anxiety, tremors, and heart-related side effects. Several note that thyroid hormones interact with other compounds and can overshoot easily. Alternatives like anavar, clen, GLP-1s, or peptides are mentioned instead, though some still caution about sides and suppression.

What this discussion establishesWhere people disagree

Some see thyroid optimization as too risky for healthy people while others are already on T3/T4 and trying to fine-tune it

Still open

Whether low-dose thyroid meds would meaningfully help a lean person reach a specific summer physique goal

Nothing here is advice.

33 replies · 11 people
BrightBeacon35archiveopening postMay 21

Anyone familiar with these thyroid levels and ever tried T3 or T4 like levothyroxine? Mine sits at 3.3, which is not technically high but not low either. The upper limit is around 4.2. I know places to get the compounds but have never experimented with thyroid stuff before. Curious what others think.

CopperMarble29archiveMay 21

If you want the details they are covered on page 593 for T3 and 595 for T4. I steer clear because I dislike anxiety and tremors and try to avoid anything that tends to produce those effects. They also interact with other compounds, which feels risky when interactions are not well documented. A lot of bodybuilders use them to raise metabolic rate and drop fat faster.

PlainQuill53archiveMay 22

As someone with Hashimoto's whose levels swing every few months, I would not touch it without a doctor or at least full blood panels every eight weeks. The ups and downs have caused me a lot of problems over the years. Please be careful.

LevelTimber10archiveMay 22

If I did not have to take levothyroxine I would not. The anxiety, tremor, and chest pain from the anxiety are unpleasant. Taking it at night reduces some of those effects for me.

AmberAnchor88archiveMay 23

Getting thyroid levels right is tricky and I would not experiment without an endocrinologist. I am on both T4 and T3 and have gone back and forth between hypo and hyper symptoms while trying to dial in the dose. The symptoms on either side are rough.

PatientBeacon30archiveMay 23
↳ replying to @BrightBeacon35 (opening post)

Do not mess with thyroid meds. I have been at both the low and high ends of normal and it does not change how I feel or how easily I lose weight. Starting to adjust things can lead to payback later.

SlowSignal40archiveMay 23

I have picked up a few points from discussions here. Some want to induce a mild hyperthyroid state to speed metabolism. One person is apparently resistant to glucagon due to low thyroid, so higher thyroid activity might affect GLP-1 response in the other direction. That could mean GLP-1 doses need adjustment and hypoglycemia risk rises. My mother had a thyroidectomy years ago and has been on replacement since; even small changes in dose produce big effects.

BrightBeacon35archiveMay 23
↳ replying to @SlowSignal40

Thanks for the reply. I am not using any GLP-1. I am 6'1 and around 170 pounds, just aiming for a lean summer look. I was curious because I do not see much talk about thyroid compounds.

SlowSignal40archiveMay 23
↳ replying to @BrightBeacon35

I can speak to that goal. Assuming you want to cut, have you tried the usual thermogenic fat burners? Besides anavar, clen, salbutamol and similar compounds there are also diuretics you could consider.

BrightBeacon35archiveMay 23

I already have some anavar and clen. I just need to decide to move beyond natural training. I am not on TRT and have never run a cycle, but I am thinking more of a recomp that keeps weight steady while dropping fat.

SlowSignal40archiveMay 23
↳ replying to @BrightBeacon35

I would skip clen. You can get results from fat burners and modafinil. GLP-1 compounds can also help with recomp. PEG-MGF, IGF-1 DES, BPC, and TB-500 pair well with anavar too.

SteadySparrow49archiveMay 23

I would not touch thyroid directly. Since T4 converts to T3 in the liver, get liver values checked and consider adding glutathione. Just know it has a strong smell.

PatientFenwick91archiveMay 23
↳ replying to @BrightBeacon35

If the only goal is getting ready for summer, thyroid meds would be the last thing I would add. Low-dose reta, test, GH or tesamorelin, and mots-c are safer and more effective choices. I have used T4 and T3 on and off and they are not something to start just to get leaner when you are otherwise healthy.

BrightBeacon35archiveMay 23

Thanks to everyone for the replies.

BrightBeacon35archiveMay 23
↳ replying to @SlowSignal40

Have you ever run anavar by itself and then used enclomiphene or something similar for PCT? I understand suppression is an issue but I do not want to end up on TRT.

SlowSignal40archiveMay 23
↳ replying to @BrightBeacon35

Yes, on my last var run I got acne on my scalp. I used anastrozole then tamoxifen for PCT. Still, I would avoid TRT for now. I am currently running var with anastrozole during the cycle.

PlainTimber26archiveMay 23
↳ replying to @SlowSignal40

I know this is not the main topic, but you have mentioned modafinil a few times. What effects do you notice and what dose do you use? I ordered some 100 mg tabs but have not tried them yet. They came up when I was looking for ADHD options.

SlowSignal40archiveMay 23
↳ replying to @PlainTimber26

It was created for narcolepsy and promotes wakefulness without the jittery feeling of caffeine. It improves clarity and focus, reduces appetite, and increases energy. I take 200 mg tablets. I am not sure how well it helps ADHD but it does lift mood. There are other similar compounds. Start with half of a 100 mg tablet. You could also try euphoria.

SteadySparrow49archiveMay 23

What about impact on the heart?

SlowSignal40archiveMay 23
↳ replying to @SteadySparrow49

Thyroid hormones? Definitely. They can make your heart race like a jackhammer.

BrightBeacon35archiveMay 23
↳ replying to @SlowSignal40

Nice, I already have enclomiphene and tamoxifen.

SlowSignal40archiveMay 23
↳ replying to @BrightBeacon35

Then you just need anastrozole and you can do the summer look you are after.

SharpCompass96archiveMay 24
↳ replying to @PatientFenwick91

I take 60 mg of selenomethionine daily. My thyroid numbers were normal but I wanted to optimize. After a little over three weeks I feel better. I stopped briefly at the start and noticed a mood dip, so I resumed. My DHEA was low so I tried 15 mg every other day but stopped after a week due to irritability.

CopperMarble29archiveMay 24
↳ replying to @BrightBeacon35

I agree with that suggestion. When I used enclomiphene it raised my testosterone but also gave high estrogen symptoms. I did not need a prescription AI; arimistane at 25 mg twice a day brought my E2 back to baseline. I have a chart showing the results if anyone wants to see it.

SlowSignal40archiveMay 24
↳ replying to @CopperMarble29

I would use both anastrozole and tamoxifen to block estrogen through two different mechanisms. One stops conversion while the other competes at the receptor. That covers the bases and helps avoid sides.

BrightBeacon35archiveMay 24

You all know a lot and I appreciate the advice. I am not a bodybuilder and do not want to inject anything. I am thinking of a short oral-only anavar run once a year before summer, maybe six to eight weeks, with the necessary ancillaries.

SlowSignal40archiveMay 24
↳ replying to @BrightBeacon35

Just to clarify, those other compounds I mentioned are also orals.

BrightBeacon35archiveMay 24
↳ replying to @SlowSignal40

I know. I was just agreeing with the oral-only approach you outlined.

SlowSignal40archiveMay 24
↳ replying to @BrightBeacon35

Fair enough. Keep in mind you only get beginner gains once, so the choice is yours. I dislike injections because of the pain, but somatomedin and MGF versions pair very well with anavar.

BrightBeacon35archiveMay 24
↳ replying to @SlowSignal40

I have never tried MGFs. Can you tell me more?

SlowSignal40archiveMay 24
↳ replying to @BrightBeacon35

IGF-1, also called somatomedin, is a major driver of muscle growth but competes with insulin on glucose handling. MGF is the spliced variant that promotes growth. PEG-MGF is the longer-acting form that supports steady gains and fat loss. It can be injected under the skin on the stomach with no pain and no effect on natural hormone production.

SteadySparrow49archiveMay 24

Will it produce noticeable gains?

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T3 and T4 · ZyraTrack Community