After 2 years on Tirz where to go next? Elora or Maz?

Did you ever consider moving tirzepatide up to 20 mg?

First, huge congrats on the weight loss. Dropping from 15 mg tirzepatide down to 7.5 mg plus 4 mg retatrutide is bound to leave you hungrier than before. Retatrutide does not seem to suppress appetite much for me either; I actually felt hungrier on it than on nothing. An option worth trying is raising tirzepatide again and adding only a small amount of retatrutide for the glucagon effect. With cagrilintide, give it the full week then consider 500 mcg. It took time to notice for me.

Retatrutide still has a decent chance of helping once you reach 12 mg, though after your long stall on 15 mg tirzepatide and the amount already lost it probably will not produce dramatic extra loss. It should at least help prevent regain. Doses above 12 mg could be considered if sides allow. Either cagrilintide or eloralintide looks like the stronger add-on choice; eloralintide has less data so far but appears to give more weight loss and fewer sides than cagrilintide. Since you have already started low-dose cagrilintide, it may be worth titrating that slowly first and switching to eloralintide only if sides become an issue. The only human combo data we have is with cagrilintide and semaglutide, which helped but not as much as hoped and with fairly high side-effect rates. This exact situation has not been studied much yet.

I think you should try retatrutide plus eloralintide, or just retatrutide first to see how it goes and add eloralintide later if you plateau. That combination is supposed to be really effective.

I hit a long plateau myself and realized the real issue was my overall intake rather than needing extra medication. Once I started tracking every single thing I ate and chose bigger portions of lower-energy options instead, the scale finally moved again. Those drugs work better as a tool to shift habits than as the main driver for dropping pounds. Being consistently active helped a lot, yet the months without progress showed I was still taking in more than I burned. Using an app to log meals made the hidden extras obvious, since the built-in estimates often turned out inaccurate. I kept hoping the hunger control would return, but filling up on lean protein and high-volume meals gave me the same effect in the meantime.

You have been in a very large calorie deficit, so your body is working hard to get food back in. Have you considered cagrilintide with semaglutide? It should give strong appetite suppression. Another option is returning to 15 mg tirzepatide and adding retatrutide slowly.

For people who started quite heavy, these drugs losing effectiveness before goal is a real problem. If it were me I would split doses every 3.5 days for both tirzepatide and retatrutide and raise the dose. Hopefully compounds like eloralintide will keep moving forward and give new options for those who have built tolerance.

I am also approaching the two-year mark. I stacked retatrutide for weight loss and tirzepatide for appetite suppression. Weight has stayed stable in maintenance, but the suppression has weakened and that concerns me. I plan to switch from tirzepatide to eloralintide while keeping retatrutide. On a side note, I wondered why the company released the rodent studies while human trials combining tirzepatide and eloralintide are still running. It may be because early human results look good but are not ready for release yet, so the rodent data served as a signal that the combination works. Eloralintide alone matches tirzepatide for effect with lower sides, and adding it to tirzepatide after a plateau appears to restart loss. I am in maintenance, which is outside the studies, but I am willing to try. I am still worried about regaining the 112 lb I lost.

Thanks, that helps a lot. I get bloodwork every three months because of rheumatoid arthritis, and the values have improved a lot since starting tirzepatide two years ago. I am now inflammation- and pain-free for the first time in twelve years, and my doctor is pleased. I also have Hashimoto’s, which made weight loss difficult before, so tirzepatide was the first thing that worked in forty years of obesity. I will titrate retatrutide up slowly and keep tirzepatide at 5 mg for inflammation control. I probably just need to be patient with retatrutide; 4 mg may still be too low to restart loss. I will also try splitting doses to see if that helps control hunger.

No, I stayed on the original product the whole time and never switched sources for tirzepatide. The retatrutide and cagrilintide are from research sources. The pens I have now expire in early 2027, so I wondered if that could be a factor. I have thought about reconstituting some tirzepatide from a research source just to test whether it feels different or stronger.

I would not have lowered the tirzepatide yet. Why not keep it the same and slowly increase retatrutide?