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💡A 🆒🆕 Topic: ♟️Nootropics ♟️💡

9 replies6 peopleMay 2, 2026☆ Follow
Summary

What personal experiences do users report with nootropics like modafinil, bemethyl and methylene blue, especially combined with retatrutide and effects on cognition or impulsivity?

One user describes starting retatrutide and testing nootropics via Wonderlic scores, finding modafinil gives a small boost while bemethyl plus methylene blue produced a striking change on the second trial. Long-term users note continued use since around 2010 with timing tweaks needed for oral forms. Others clarify retatrutide modulates dopamine to lower reward-pathway firing and impulsivity rather than acting as an agonist, and question methylene blue's value due to toxicity risks at higher doses.

What this discussion establishesWhere people disagree

Whether methylene blue provides meaningful cognitive benefits or is mainly ineffective and risky at scale

Still open

Long-term outcomes or reliable cognitive gains from combining these compounds with retatrutide

Nothing here is advice.

9 replies · 6 people
SlowSignal40archiveopening postMay 2

Yeah, had a fresh kind of experience recently. Began Reta two days back. Besides the stubborn obesity issue, the diabetes messed with my mind too. My IQ fell by at least twenty points. Been looking into nootropics and tried a bunch with mostly small results. Modaf stands out though. I check them using a Wonderlic test, fifty questions in twelve minutes. Normally finish in ten minutes scoring fifty-five to sixty. With Modaf, done in nine minutes around sixty to sixty-two. Bought six bottles of different compounds, tested two with Modaf: Bemethyl and Methylene Blue. Last week tried it and surprised family when my urine turned blue after peeing, but cognition didn't change much. Today was another story entirely though.

PatientBeacon27archiveMay 3

First heard of nootropics back in 2006 or 2007. Started using them around 2010 and continue to this day. These days though, ones taken by mouth need adjusted timing.

SlowSignal40archiveMay 3

Got any details on how they work for you?

WarmQuill45archiveMay 3
↳ replying to @PatientBeacon27

Which compounds? And how do things go if you stop taking them for several months?

NorthLantern66archiveMay 3
↳ replying to @SlowSignal40 (opening post)

A urine hue shift after methylene blue exposure signals the amount must have been excessive. This agent affects dopamine signaling much like the others do, which in basic terms means lower levels of impulsive actions. Reasonable evidence points toward helpful results for those managing attention difficulties, yet without further investigation that remains the limit of current knowledge.

SlowSignal40archiveMay 3
↳ replying to @NorthLantern66

Hmm, just one 10mg capsule. A dopamine agonist that cuts impulsivity? Odd. Need to look into that.

KeenPebble33archiveMay 3
↳ replying to @SlowSignal40

Not an agonist, more of a modulator. It lowers the activity of dopamine neurons in the reward system, which leads to reduced impulsivity.

SlowSignal40archiveMay 3
↳ replying to @KeenPebble33

Ah, that checks out. It gets rid of cravings. Understood.

ClearWillow59archiveMay 3

Look up nootropics, other threads have additional details.

NorthLantern66archiveMay 3
↳ replying to @SlowSignal40

I use liquid methyl blue but it has little effect on me. At larger amounts though it's toxic. Studies don't point to specific advantages from it either.

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💡A 🆒🆕 Topic: ♟️Nootropics ♟️💡 · ZyraTrack Community