Half-lives / Retatrutide
Retatrutide half-life
Retatrutide stays in your system about 30 days — five half-lives at a half-life of ≈ 6 days (144 h). The computed decay curve is below, with the primary source cited.
Also searched as: reta, ly3437943, triple g.
Source: Retatrutide phase-2 pharmacokinetics (Jastreboff, NEJM 2023; half-life ≈6 days)
Frequently asked
How long does Retatrutide stay in your system?
With a half-life of ≈ 6 days, roughly 97% of a single Retatrutide dose is cleared after five half-lives — about 30 days. Repeated dosing accumulates and takes correspondingly longer to clear.
What does a ≈ 6 days half-life mean in practice?
Every 6 days, the remaining amount halves: 100% → 50% → 25% → 12.5%, and so on. The curve above plots exactly this decay for a single dose.
Where does this Retatrutide half-life number come from?
Retatrutide phase-2 pharmacokinetics (Jastreboff, NEJM 2023; half-life ≈6 days). We cite a primary source for every half-life we publish and version every change.
Related: Retatrutide reconstitution calculator · Retatrutide dose charts
Watch: Retatrutide reconstitution: the complete guide (BAC water, mixing, mg to units)
The complete retatrutide reconstitution guide: what you need (vial sizes, bacteriostatic water, U-100 insulin syringes), why the amount of BAC water never changes your dose — it only sets the concentration, the four mixing steps (wipe both stoppers, water down the glass wall, swirl — never shake — u From our official channel — education only, never a dosing recommendation. Watch on YouTube ↗
Discussions
From the ZyraTrack community · on retatrutide
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Related half-lives
Other GLP-1 & incretin agonists — how long each stays active:
Guides mentioning Retatrutide
See your own estimated levels
The Zyra Track app plots this curve from the doses you actually log — accumulation, overlaps, and all. Free during the founding period.
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