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EloraTZP: Is This The Strongest Weight Loss Drug Yet?

24 replies12 peopleSep 30, 2026☆ Follow
Summary

How does Elora stack with existing GLP drugs like Tirz and Reta for weight loss, and is it worth trying?

Users discuss pairing the amylin agonist Elora with Tirzepatide as a non-overlapping pathway that may avoid receptor saturation compared to stacking multiple incretins. Personal reports mention steady 1% weekly loss on high-dose Reta plus low-dose Tirz and Elora, with fractured sleep as the main side effect. Business logic favors testing Elora with the established Tirz to extend its market life rather than with the newer Reta. Dosing experiments continue but long-term data remains limited.

What this discussion establishesWhere people disagree

Whether Elora pairs better with Tirz or Reta, and whether adding another incretin or switching to the amylin route is preferable.

Still open

Long-term safety of triple stacks, optimal dosing for each combination, and whether amylin agents blunt Reta's glucagon effect.

Nothing here is advice.

24 replies · 12 people
PlainAlder11archiveopening post3d

You posted the same link twice?

WarmAnchor23archive3d

Makes sense Reta isn't included since it isn't officially released, but wouldn't it combine better anyway?

↳ replying to @WarmAnchor23

Elora isn't approved either. Maybe Tirz would be the stronger pairing instead?

AmberPebble67archive3d
↳ replying to @CopperHarbour89

Why? Too many new options popping up at once. I'll stay with Reta for now, the idea of coming off sounds rough.

↳ replying to @AmberPebble67

Fair enough, whatever works for you. I figure combining two strong incretin drugs might just overload the receptors. The write-up says Elora uses a different amylin route that complements Tirz without repeating the same signals, so maybe that avoids redundancy. I'm currently on Tirz plus Reta but the idea of skipping the overlap is appealing. Still digging into it.

↳ replying to @CopperHarbour89

Could be the company wants to test the new compound against an already-approved drug to speed approvals. My target is one percent loss per week so I'd probably need to adjust the dose to stay on track. From what I've seen, running Reta with Tirz and Elora together has worked well.

↳ replying to @LevelThistle44

That could be it. Tirz and Reta have worked okay for me despite the usual ups and downs. This newer combination just feels logical for some reason. Time will tell.

AmberPebble67archive3d
↳ replying to @LevelThistle44

Your own observations? You mean you had your rat try all three at once?

↳ replying to @AmberPebble67

Right now I'm on 20 mg Reta, 2.5 mg Tirz, and 1 mg Elora each week. About ten pounds left to go.

AmberPebble67archive3d
↳ replying to @LevelThistle44

That's a huge amount of Reta. How are you handling it and what kind of results are you seeing?

PlainAlder11archive3d
↳ replying to @LevelThistle44

Considering adding a bit of Tirz for my wife since she hit a plateau. She's finishing her fifth week at 12 mg Reta. Any idea what Tirz dose to start and whether to lower the Reta at the same time? Haven't tried this before.

↳ replying to @AmberPebble67

Down one percent of body weight every week for the last 42 weeks. Sleep is more broken but manageable. If she won't step on the scale it will be harder to track. Start with 2.5 mg Tirz and keep the Reta the same unless sides show up. The Tirz in my own mix doesn't seem to add much.

ClearKettle29archive3d
↳ replying to @CopperHarbour89

Planning to add Tirz to what I'm already running. Currently at 4 mg Reta split twice a week and hoping the extra Tirz will cut down on food noise more than Reta alone.

GreyAlder96archive3d

Always wondered if Cagri or Elora would reduce the glucagon action from Reta. If they do, maybe there's no point combining them. Amylin is released after eating and tells the body to stop making glucagon.

PlainAlder11archive2d
↳ replying to @LevelThistle44

She won't weigh in but still wants the shot every Friday, so maybe progress is happening anyway. Appreciate the details.

Makes me wonder how many different receptors tied to weight actually exist. With all these new drugs coming, are we headed toward something like an eight-receptor agonist?

QuietAnchor73archive2d
↳ replying to @PlainAlder11

Sounds like the spot to start adding Eloralintide. Wouldn't want the community to run low right when people need it.

↳ replying to @WarmAnchor23

From a business angle, Tirz is already popular and many people like it. Reta will take some of those sales as the hot new option, and other companies will launch their own versions. So does it make more sense to pair Elora with the new standout or with the older established one that might be losing ground? Pairing it with Tirz could turn that drug into another must-have and give the company two strong products.

After a couple years on these meds I settled on 2.5 mg Cagri with 12 mg Reta.

GreyAlder96archive2d
↳ replying to @SteadySparrow75

Tirz already has millions of users, plenty of them at the top dose and still wanting more loss. It makes sense to develop and market a pairing with something they're already taking.

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