Depression, and Semax, and SSRIs, oh my!

No success with Semax for me, though I saw some mild improvement with PE 22-28.

I thought Semax was mainly for focus and mental clarity rather than mood. Selank seems to be the one aimed at mood and lowering anxiety. Anyone want to correct that?

Selank helped me, but I used it alongside an SSRI instead of replacing it. Ultimately switching SSRIs and adding an antipsychotic worked best. You could try it without much risk, though don't count on big results. Early effects can be placebo, so check if they hold up. Good luck.

There are tons of antidepressants besides just SSRIs.

The contraindication concern seems overstated without knowing the exact heart issue. I'm on tricyclics despite heart disease. Avoiding bupropion over past history alone feels excessive if weight is stable now. There are SNRIs beyond SSRIs too. Some supplements show evidence for depression, including fish oil, l-methylfolate with SSRIs, vitamin D, l-carnitine, and PEA.

Grateful for all the ideas and stories shared by others. Following additional investigation we've chosen to combine Selank with Semax and maybe P21 as well. I'm going to record our progress here hoping it might assist someone later on. We'll add them sequentially to spot any issues or adverse effects early on. Beginning with Selank at 250 micrograms injected under the skin we'll raise it to 500 if no problems arise. The same approach applies to Semax. Once we've finished two rounds of those we'll assess her emotional state and anxiety then decide whether to tweak things or start P21 through the nose. Sharing progress reports as we go for those who want to track along. With luck what we go through will benefit others thinking about this path.

I'd like to see your updates.

I'm about to start another P21 cycle. It works well with Semax and its versions. I found it helpful and would like to hear how it goes for you.

My wife has had long-term anxiety and depression. Semax and Selank didn't do much, but oxytocin helped her feel more connected to herself and her priorities. We might try the first two again.

Mine is ready to ship once the test report comes through.

Not depressed right now, but have you considered a GLP-1? Reta gives me a steady sense of satisfaction and reduces cravings for other things.

Unapproved and unstudied nootropics worry me because delivering compounds past the blood-brain barrier isn't simple, and the risks in this area often get overlooked.

Describing this is difficult for me because I get nothing from it myself. My partner uses it in a tiny amount and right away feels affection along with a sense of calm and ease. She loses the urge to handle matters she can't influence. That's the way she talks about this item. Finding some isn't simple but the cost isn't high if it turns up.

I've been wondering if mushrooms came up as something she tried, since evidence points to benefits there. As for these compounds, anxiety has plagued me ever since my delivery five years back due to the trauma around childbirth. One gave slight relief. The other leaves me too wired so I've stayed away from it. Lately I've started checking out another that might suit better. Both can go under the skin via injection or get turned into nasal sprays by some, though any difference in results isn't clear to me and I've used the shots. Stronger help was what I expected from that one. Those classes of antidepressants did nothing either. At this point it feels like I'm defective with no way out of the endless pain.

Haha, that earlier remark of yours looks like it holds some groundless comedy, agree? 😎

I've never come across that pep from the sources I typically rely on, which makes me wonder if it's stocked anywhere else.

Using that compound ended up heightening my spouse's inability to feel any pleasure and people see varying effects from it.

For more than sixteen years those two prescriptions at the stated levels have kept my mood issues under control after the initial bipolar diagnosis shifted into major depression. This year hit with sudden deaths of four close relatives before summer closed out including my partner's dad during a standard heart procedure an aunt from hidden cardiac and pulmonary conditions a cousin whose cancer returned and my mother after abrupt intestinal blockage followed by infection stomach issues blood poisoning and finally breathing failure. She had shared my home for a decade. The losses dropped me into a deep clinical low I could not escape. Doses were already high and I raised one slightly yet the actual turnaround came from rotating two particular compounds alongside three workouts weekly plus a nasal spray each day. It lifted the mental haze let me sort through feelings and restored drive to leave bed and regain direction. My age in the late forties could matter here. I feel better now and intend to try one more item before sleep once it shows up.

My eighty-three-year-old mom receives one milligram of Selank every day for a month, then takes a month off. In the off month she gets one milligram of Semax along with one milligram of Pinealon. Selank maintains her cheerful disposition, whereas the other pair provides limited help against low mood yet mainly supports thinking abilities. Before leaving for my job each morning I come over to hand her the daily doses. Nothing bad can come from giving it a try. Wishing you success.

My relative tried those two compounds and said they seemed to ease her low mood. I have not used either one yet but expect to order them during my next gray market buy.