ForumReconstitution & Math

GHK-CU Cream Ideas?

17 replies8 peopleJun 17, 2026☆ Follow
Summary

How to mix GHK-CU powder into creams or serums for body and face use while handling pH, preservatives, and solubility

Users discuss adding reconstituted GHK-CU to various bases, with some preferring hyaluronic acid serums and others trying lotions. Concerns arise about introducing water that can reduce preservative effectiveness and allow bacterial growth, leading to suggestions like glycerin instead. Experiences vary on whether fat-based creams work without water, and one user notes a commercial cream already contains a related peptide. Practical tips include checking ingredient compatibility and sterilizing tools.

What this discussion establishesWhere people disagree

Whether water-based reconstitution is safe or necessary before adding to creams, and how well the peptide works in lipid-heavy bases

Still open

Exact mix ratios and long-term stability without dedicated preservatives

Nothing here is advice.

17 replies · 8 people
GreenKettle22archiveopening postJun 17

Anyone tried blending this powder into various creams? I have some on the way and want to experiment with a few bases. The usual hyaluronic acid serum mix is one plan. Looking for ideas on good creams to try, though some options seem pricey. Maybe a basic cream, an ointment, or even an inexpensive vitamin E cream. pH levels need watching. Any experiences would help. Thinking the serum for face and scalp while creams go on the body for easier spreading, though the serum might work everywhere too.

ClearWillow59archiveJun 17

There is a thread here worth searching and also on reddit under skincare topics. I have been adding it to creams. Some only suggest certain hydro lines but I have used palm blends too. The one in the round tub works especially well. I partially mix the powder with water then add that to the cream and stir thoroughly. I also blend it into hyaluronic serum, certain ones work well. You can look up the right ratios, sorry I do not recall right now and I am heading out.

GreenKettle22archiveJun 17
↳ replying to @ClearWillow59

Thanks for the reply. I have been reading quite a bit here but did not find much specifically on creams. Will check out the suggestions. Thanks!

GreenMeadow27archiveJun 17

I strongly advise against adding it to water before mixing into a body product. Adding water to anything opens the door to bacterial growth. Preservatives are there but their amounts are set for the original formula. Extra water means the preservative cannot handle a bigger bacterial load.

GreyAlder39archiveJun 17

Just to note, one company has put out a cream that already includes a related peptide.

GreenKettle22archiveJun 17
↳ replying to @GreyAlder39

Do you mean the hydrating hyaluronic acid water gel version?

PlainLedger95archiveJun 17

I made a serum with it that felt sticky and looked blue on my face so I did not like using it that way. I mixed the whole thing into some lotion I had and now I enjoy it. The lotion actually feels better to me than before. As long as you check the lotion ingredients for any reactions with the peptide using a search, there are probably many workable choices. I included a photo of the final lotion after two weeks in the fridge along with its ingredient list.

GreyAlder39archiveJun 17
↳ replying to @GreenKettle22

I do not recall exactly. I just noticed it at the pharmacy last week.

ClearWillow59archiveJun 18
↳ replying to @GreenMeadow27

I used bac water that had been open for a while. I read that this peptide does not dissolve in fat, so mixing into non-water-based creams means it will not work. That is why the hydro products get recommended, though they cause breakouts on my skin. The palm version is rich and nice on aging skin but it is fat based, so water gets suggested. I am not a skincare expert though, just following what others say.

GreenMeadow27archiveJun 18
↳ replying to @ClearWillow59

I just do not want anyone reading about water and ending up with a skin infection. Something like glycerin works better for cream products. It will also bring humectant benefits. Keep in mind glycerin will make the lotion or cream a little thinner.

PatientBeacon15archiveJun 18

There is a preservative product you can add to water-based mixes, just a few drops. You may want to look into other experiences with it first. Lecithin might help emulsify it into a lipid base for better skin penetration. An AI tool can actually help generate recipes for topical mixes.

ClearWillow59archiveJun 18
↳ replying to @GreenMeadow27

You can blend into an HA serum first and then add that, which sidesteps the water problem. Sterilizing the mixing tool is probably smart too. Nothing went wrong the first time I tried without those steps, maybe I was lucky with no broken skin. Thanks for the reminder.

GreenMeadow27archiveJun 18
↳ replying to @PatientBeacon15

Lecithin can be tricky for beginners because it tends to clump and does not spread evenly. AI is not the most reliable source for actual recipes either.

GreenMeadow27archiveJun 18
↳ replying to @ClearWillow59

There is harm reduction even when it comes to skin care. I made bath and body products for a long time.

ClearWillow59archiveJun 20
↳ replying to @GreenMeadow27

That sounds interesting, I always thought I would enjoy doing that kind of thing.

GreenMeadow27archiveJun 20
↳ replying to @ClearWillow59

It takes a lot of effort. I began with cold process soap and it just grew from there.

AmberTimber37archiveJun 20

I got the copper peptide in powder form since I planned to blend it into cream. Prednisone left me with awful skin troubles. Anybody know the right proportions for combining them?

LevelBramble14archiveJun 20

A channel on the video site has a recipe posted.

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