Been on Reta, stack, or go back to Tirz?

Almost eight weeks at that dose. Checking my logs shows it has actually been five months total on Reta. Thanks for the input. I have not come across much on combining Reta and Tirz, so I am trying to find more details on how to set it up. We are in the grey area here, and stacking is new territory for me even though it seems common for others. I did not fully appreciate how complete the zero food noise was on Tirz until it was gone.

You kept the Tirz at a dose you could handle while slowly adding Reta, and now you run a full clinical dose of Reta plus a small Tirz amount? That is close to what I am thinking about, especially given the side effects I have had with each one separately.

I will look into that option. What weekly amount of Cagrilintide are you using? Same day or staggered? I moved up on Reta very gradually and have not run into side effects.

Started Cagrilintide low at 0.4 mg because of how potent people said it was. Now around 2 mg weekly but split into smaller doses. I seem to be a modest responder. No clear bad effects except maybe some fatigue, which I prefer over allodynia. Since I am retired I can nap if needed. Checking individual accounts on forums can give more dosing examples.

I had reached 12.5 mg Tirz and the scale stopped moving. Took a break from strict calorie control to see if that would restart progress but it did not. I also doubt I would tolerate anything above 12.5 mg. Around then I had Covid followed by shingles, which might be unrelated. Once weight loss stalled I looked for other options. So far Tirz took off eighty-five pounds and I still have roughly forty left. Mid-forties female, fairly active with cycling, hiking, weights, and regular heavy lifting. The final stretch matters a lot. The worry is that returning to Tirz alone might just stall me again. Should I keep Reta and add Tirz, or try something like Cagrilintide instead? I have only ever used one peptide at a time, so the whole idea of stacking leaves me unsure how to proceed.

Planning to research Cagrilintide tonight. I had only been thinking about Tirz since that is what I came from, but if others are getting results with Cagrilintide I will look into it too.

That is a long stretch at 8 mg, so you should already know what that dose does for you. I still think adding Tirz back is worth trying. Cagrilintide does get mentioned often for food-noise control and it works for some, but since you already know how your body handles Tirz it might be simpler to go with that and avoid the indecision. Every body is different, yet the current mix is working well for me and I will only change if sides become too much. The allodynia comes and goes but I am willing to manage it until goal, then figure out maintenance doses of one or both.

A more cautious starting amount for Cagrilintide is 250 mcg or 300 mcg. One study showed weight-loss effects even at the lowest tested dose of 300 mcg weekly, with three percent loss at that level versus nearly eight percent at 4.5 mg.

Yes, you can. I am sure I do not need to explain why most choose not to.

Since moving from Tirz to Reta I have used Tirz six times for a total of 14 mg. Four of those six times were on the same day as Reta, and two of those four were at the exact same time. No obvious reason it would be a problem other than not having a clear overall plan for the doses.

Mainly the higher chance of sides, and if sides appear you cannot easily tell which compound caused them.