I do use it, two milligrams each day. I put one third into the left knee, another third into the right hand, and the rest into the left hip. Osteoarthritis affects both hips, the right hand, and both knees. It makes a real difference, cutting pain by thirty to fifty percent so I no longer need ibuprofen or aleve. Eight weeks in now, and I've begun adding one milligram of kpv. Reta has helped as well, with about twenty-five pounds lost in those eight weeks. Without the peptides it was nearly impossible to pull on my left sock. Arthritis is rough.