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Scientists boost lifespan by 70% in elderly male mice using simple drug combo

12 replies13 peopleDec 10, 2025β˜† Follow
Summary

Will the oxytocin plus Alk5 inhibitor combo that worked in old male mice translate to humans?

The thread shares a mouse study showing the combo extended lifespan and strength in very old males with only short-term gains in females, plus restored protein patterns. Users joke about sourcing the compounds immediately, note that rodent results often fail to match human biology especially for peptides, and debate trying things without human data. Skepticism about translation and side effects runs alongside humorous takes on living longer.

What this discussion establishesWhere people disagree

Whether low price and a lab PDF justify skipping human trials for peptides

Still open

Whether any version of this approach would be effective or safe in people

Nothing here is advice.

12 replies Β· 13 people
PatientAnchor36archiveopening postDec 10, 2025

A study showed that pairing oxytocin with an Alk5 inhibitor brought back vitality in very old male mice, increasing how long they lived and their strength. Females had only temporary gains, pointing to big differences between sexes in how aging works. The treatment also brought protein patterns back to younger states. Figured the group would want to check it out even though it's mice and the 70 percent boost is notable.

BlueTimber78archiveDec 10, 2025

Who else is searching for an Alk5 inhibitor source right away instead of checking the actual paper first?

CopperSignal27archiveDec 11, 2025

From what I recall, there aren't any natural ALK5 inhibitors out there that are specific enough, free of side effects, and proven safe in animals or people. Still, glycine, NAC, and ergothioneine look promising.

SharpThistle20archiveJan 28

My leg joints have totally failed me, my hip sockets are wrecked beyond repair, and the arthritis in my lower spine makes me worry I won't last much longer. For real, if someone gave me the chance to swap for good joints but lose some time alive, I would probably go for that option. Only teasing though a bit πŸ˜‚

SlowHarbour21archiveFeb 5

Totally! My actions will drain social security dry!

SharpCinder28archiveFeb 5

Quite a few compounds appear to deliver stronger effects in rodents than they do in people. One such compound illustrates this point well, as rodents feature many beta-3 receptors which humans simply lack.

QuietFenwick11archiveFeb 5

Yeah, the research makes it look like care for rats and mice has moved way ahead of anything developed for people.

SlowBramble78archiveFeb 5
↳ replying to @SlowHarbour21

Wondering about those government retirement payments? I could track down the details to reach the specialist handling my money matters.

BlueThistle84archiveFeb 5
↳ replying to @QuietFenwick11

Besides these have gone through way more checks which makes me confident they perform better too.

NorthMeadow39archiveFeb 5
↳ replying to @SharpCinder28

True. Reactions don't match up between people and rodents like that. Plenty of compounds from initial research stall out later since the results shift when tested on us. So I avoid peptides unless some studies in people look encouraging.

NorthLantern99archiveFeb 5
↳ replying to @NorthMeadow39

Well, supposing the cost checks out along with a report from some institute whose name I struggle to say, why even consider trials on actual people? πŸ˜†

ClearTimber11archiveFeb 5
↳ replying to @NorthLantern99

My self-perception aligns with mice so I am searching for Alk5 inhibitor since oxytocin already belongs to me.

QuietAnchor73archiveFeb 5
↳ replying to @SharpCinder28

I've been wanting to express my gratitude for the value you add in this discussion, thanks a lot. Generally I'm not fond of these AI language models since they can sometimes generate odd or inaccurate stuff, yet this one appears to offer relevant details that help in judging possible human effectiveness. Does it include references, I wonder? Also I'm interested in the exact wording of the prompt you used. It would be great to check what the output from that model says about the artificial four-amino-acid chain known as KEDP.

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