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ACE-167 + FOXO4 + Kisspeptin + Testagen

4 replies5 peopleJan 2, 2026☆ Follow
Summary

Does a stack of ACE-167, FOXO4, Kisspeptin and Testagen improve natural testosterone production?

Users discuss mechanisms and sequencing for the proposed peptides but reach no consensus on effectiveness. Several participants report preferring established options like enclomiphene over experimental peptides and note kisspeptin requires frequent dosing to matter. One user shares before-and-after labs from a related kisspeptin plus Tesamorelin protocol showing total and free T increases.

What this discussion establishesWhere people disagree

Whether unproven peptides are preferable to HCG or enclomiphene for optimizing testosterone

Still open

Whether the exact proposed stack produces measurable gains in healthy men

Nothing here is advice.

4 replies · 5 people
SharpFenwick93archiveopening postJan 2

Anyone run this combination before? It looks like it could help support the body's own testosterone output. Never used any of them myself, but the idea is FOXO4 clears out old Leydig cells, Testagen then pushes Leydig cell activity and supports protein synthesis genes in the testes, ACE further activates those cells, and Kisspeptin raises LH plus FSH to drive testosterone higher. The order seems sensible: remove the bad cells, stimulate the good ones, amplify them, then boost the gonadotropins. Keeping the person who messaged private unless they want to join, but thanks for the note on adding Testagen and Kisspeptin. Mostly just curious here. At the age when lots of guys start TRT I still lack the usual symptoms except extra body fat, so I've stayed away from it and don't want to add HCG or stronger compounds when the goal is natural optimization.

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QuietFenwick11archiveJan 6

Looked into kisspeptin for raising testosterone. It fails to deliver unless injected multiple times daily or given as an infusion. It does raise LH and FSH reliably in the short term. Need to determine primary versus secondary hypogonadism first, since nothing peptide-based fixes primary cases. Switched to enclomiphene myself and saw good results.

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QuietFenwick27archiveJan 10

Considering several peptides that have little human data instead of something like HCG that is proven, cheaper, and well tested? Enclomiphene could be worth checking too. First step is getting actual testosterone numbers measured to see if optimization is even needed.

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BrightBeacon35archiveJan 10

Would pass on that whole stack. Boron, black maca, tongkat ali, shilajit, high-dose vitamin D with K, and ashwagandha are worth trying first for a natural route. Some people notice decent changes from those. For guaranteed results only actual testosterone or enclomiphene work reliably. Skip clomiphene due to the isomer that can cause eye issues. HCG only matters if fertility is a concern.

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PatientPebble85archiveJan 10

Just finished a comparable approach with kisspeptin each morning and tesamorelin each evening for six weeks after an earlier ipamorelin plus BPC-157 run. Labs before the first stack showed total T at 500 and free T at 4. After eight weeks on ipamorelin and BPC total T moved to 664 and free T to 7.8. SHBG sat at the high end of normal at 72 so added DIM when switching to the newer peptides. Blood work is scheduled again this week to check if total and free T moved further. The GHRP seemed responsible for the earlier gains rather than BPC. Hoping the GHRH and kisspeptin push numbers higher still. Also been adding r

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