Add Reta or Cagri to Trz?

Same boat here. Not gaining but not dropping either for four or five months straight. Even tried 17.5 and 20 mg with no movement. Food drive feels like it did before Tirz started. I already have both Cagri and Reta on hand but can't decide which one to try, so any input would help. Still need to lose 12 lbs.

Similar spot for me. Started Tirz last July and now pin 6 mg every five days. Not exactly stalled but those last five pounds refuse to budge. I could live with where I am, yet a goal is a goal and I've come too far to quit. Raising Tirz is an option but I'd rather keep the dose low for maintenance so my supply lasts. Ordered two vials of Reta and plan to try a tiny starting dose three days after my Tirz shot to check tolerance and results. Considered Sema but hoping Reta's blood-pressure benefit shows up. Can't begin until the vials arrive later this week.

You probably began Reta at too high a dose. I prefer Cagri because it hits amylin receptors that neither Tirz nor Reta touch. I inject on a six-day schedule offset by three days. Started Tirz about twenty months ago. After passing 10 mg I added low-dose Cagri and slowly raised Tirz to 20 mg weekly. Cagri upset my stomach but wiped out food cravings completely. Later added 0.5 mg Reta and titrated up while lowering Tirz to 10 mg weekly. Six months after that I stopped Cagri. Ran all three together for half a year before dropping Tirz another six months later. Down 92 pounds total and now alternate Cagri and Reta for the remaining 10-15 lbs. Splitting each peptide into half doses every three or four days didn't change loss speed. Never stopped any abruptly; always tapered over four to six weeks. Whenever a stall lasted two or three weeks I changed one variable. Sema looks weak next to the others.

No hands-on experience stacking GLP-1s myself, but it seems smartest to skip it. Tirz already covers GLP-1 and GIP, so the only new piece from Reta would be glucagon activity and I'm not convinced that's worth adding. Cagri works through a completely separate amylin pathway with zero overlap, so layering that onto Tirz makes more sense right now. Only consider switching fully to Reta if Cagri on top of Tirz doesn't move the needle.

Thanks everyone, this thread gave me exactly what I needed. Any pointers on where to look for Cagri dosing schedules?

Late to the thread and my Tirz dose is lower than most, but adding Reta finally ended a stall when I went much slower than you did. Tirz on Friday mornings, Reta Monday nights. Began at 0.5 mg weekly, moved to 0.75 mg after two weeks, then 1 mg after another two weeks. That last step finally got things moving again.

I reached 15 mg Tirz after a year of nausea on Ozempic and still felt hungry, but didn't want to stop Tirz since it was working. Added 5 mg Reta later and then 0.25 mg Cagri every four days. Dosed smaller amounts every two days mainly to limit nausea the way I had to with Ozempic. That combo got me the last 13 kg down to 65 kg from an original 145 kg. Maintaining such a big loss seems to require the higher doses and stacking. Twice-weekly dosing made adjustments faster but weekly would work if done slowly. Noticed mild nausea from the 0.25 mg Cagri and spent a couple months figuring out if I could tolerate it.

Posting this for anyone who searches later, including future me. Low and slow seems safest. Cagrilintide schedule: week 1 at 0.25 mg, week 2 at 0.5 mg, week 3 at 1.0 mg, week 4 at 1.7 mg, then 2.4 mg maintenance from week 5 onward. Full ramp takes 16 weeks with once-weekly shots.