Anaphylaxis and allergic reactions from a paramedic

Haven't seen any, but these compounds are still used by a fairly small group and haven't been around that long. Things like nut allergies are much more frequent. Plenty of patients do tell me about drug allergies, though often it's a stabilizer in the vial rather than the medication itself.

Hadn't thought about the emergency number varying by region, so thanks for pointing that out.

The numbers on GLP-1 use are surprising and it's good to hear your take that problems haven't shown up much. I saw another post mention 18k overdoses in 2025. Recent data shows about 15 percent of U.S. adults have tried one, with 11 percent currently using them, up from 3 percent last year. Higher among women and ages 50-64, and over half of adults with diabetes have used them. About 22 percent of those who haven't tried one are still interested for weight loss.

Couldn't relocate the link I had, but poison control and FDA reports show around 11,000 cases through September 2025 versus roughly 8,000 in each of the prior two years. Main cause of death was severe kidney failure. Haven't come across anaphylactic shock reports, at least not with the official pens which are quite clean. With total official users the death rate works out to about one per million, mostly sema from dosing or prescribing mistakes. Main takeaway is stay hydrated, urinate often, and confirm the right amount.

The share of people with truly severe allergies is smaller than it might seem. Still, knowing the signs is worthwhile so no one gets too complacent.

I trust that. It's reassuring that issues aren't common even with around 30 million GLP-1 users in the U.S. Doesn't mean ignoring risks though, and grey-market use is smaller so other problems could be more likely there. After nearly two years on this forum I haven't seen major red flags, but that doesn't guarantee nothing will happen. Thanks for adding your perspective.