This same thing occurred for me using that product. It looks to be a fairly typical reaction from those particular peptide groups. Roughly half the users seem affected, or so i guess.
I'm seeking input about how my body reacts with histamine issues while using tesamorelin. I've reached week five on a protocol combining it with ipamorelin at 2 mg and 300 mcg respectively, following a five days on two off pattern. Early on the subcutaneous shots went smoothly aside from brief minor itching that faded quickly. Lately though things shifted after the first couple weeks the initial pin feels okay but roughly half a day later the irritation ramps up with noticeable welts and puffiness that keep growing and hit their worst around two days in. Bug bites trigger the exact same oversized itchy bumps for me unlike what happens to others around me. So far I've adjusted the bacteriostatic water amount without much change tried dividing the shot across separate body areas which made one spot slightly less bothersome but still problematic used common allergy pills that ease things temporarily let the prepared syringe warm up before use and applied topical relief creams yet the swelling and discomfort continue. My other current compounds show none of these injection site problems. Given my history with plant allergies and insect reactions producing comparable effects I'm considering blood work to check tryptase readings. Anyone else dealing with matching sensitivities found approaches that eased their symptoms such as certain mast cell stabilizers or short courses of corticosteroids.