Having only started these compounds a short while back, I don't see myself as suited to weigh in yet, which explains why I skipped adding my vote. From my limited time so far, drive for intimacy has noticeably dropped even though it usually runs quite strong. Sensations aren't fully muted overall, but some do register as less vivid, especially around that topic. My mind tends to chase rewards strongly, so this shift hasn't felt like a major downside and could even help in certain ways. These early impressions may well evolve, though. I'm working to keep things even so various parts of daily life stay enjoyable while I focus on dropping weight.
The flat emotional numbness hit me hardest of all during this process. Looking back it only surfaced once I reached a higher tirz amount and briefly tried adding another glp compound partway through. That second one caused skin pain so I stopped it but then increased the first medication further and the emptiness stayed. Because it lacked any clear trigger and felt steady rather than stormy I did not register it as depression at first unlike earlier episodes that always had an obvious cause. Family members had to point out how withdrawn I had become before I grasped the extent of it. Lowering the dose for ongoing use and sticking consistently to my usual adhd and mood prescriptions has brought noticeable relief. I wonder whether anyone else who ran into similar numbness or low mood while on these medications already carried a vulnerability or whether it strikes without pattern. My own background includes prior mood issues plus strong adhd that disrupts several brain chemicals so I may have been especially susceptible. For people who noticed this while taking a glp medication which one was involved did it begin only after a dose increase did you reduce the amount switch compounds or just keep going and do you have any past mental health or neurodivergent traits. Anyone who has moved past it should mention what actually helped.