Forum users report trying doses from 19.5 mg up to 30 mg, with most seeing no extra weight loss but increased side effects like nausea. Some stack with semaglutide or cagrilintide for appetite control and reach goal weight that way. Ongoing trials are testing 20 mg and 25 mg doses, with results expected later this year, and patents suggest even higher strengths are being prepared.
What this discussion establishesWhether doses above 15 mg provide meaningful extra benefit or simply increase side effects without added weight loss.
Still openWhen trial data on 20-25 mg doses will be released and how non-responders should proceed.
Nothing here is advice.
Has anyone tried doses higher than 15 mg of tirzepatide? I'm at 15 mg now and wondering about going higher, or maybe adding cagrilintide to help with appetite control.
I've seen mentions of current trials where some people are using 25-30 mg. I've stayed at 15 mg for a while since I'm at goal. Ongoing studies are looking at 20 mg and 25 mg doses for safety and effectiveness in people who don't respond well to 15 mg.
I read about one case in an emergency department report. Health authorities noted thousands of overdose incidents, often from people taking multiple doses or the whole pen. If 15 mg isn't working, some suggest trying reta, and if that fails it may be due to receptor mutations in a small percentage of people.
That model feels destined to come my way. Fate seems to point right at it. Including Eloralintide instead might be the move.
I tried 20 and 22 mg and felt no different from 15 mg. A few weeks ago I accidentally took 30 mg and felt awful for two days. None of those doses made me lose more weight than usual.
I've used 20 and 19.5 mg for over a month after being on 15 mg. It makes eating almost anything nauseating, and I got used to it, but I wouldn't recommend it. The medication is meant to help obese people handle a calorie deficit by slowing gastric emptying. More isn't automatically better, especially as you get closer to goal.
Yes, the first 10 months were easy and now it's suddenly much tougher and not working the way it used to.
I've done 10 mg every five days for a few months with no issues. Adding a bit of sema a few days after the tirz gave the best appetite suppression. Cagri works for that too. I've used all three at times and they helped me reach goal.
Didn't lose more weight than usual, or were you stalled and didn't lose more? Both could be true, but the phrasing suggests you were still losing at the normal rate.
I have no problem with going past 15 mg if needed, though I'm not there yet. Does anyone know when the studies might release results?
From what I can tell it looks like fall of this year.
Curious how much sema you added. Would you mind sharing more? I'm at 15 mg weekly of tirz but it's not working like it used to. I have some sema and am thinking of adding it to my rotation.
I checked all the reference links thoroughly but couldn't find any source for the 25-30 mg doses mentioned. The only mention came from a blog citing unnamed sources. The trial information itself doesn't specify the doses being tested.
This is what led me to the trial. The company is running phase 2 studies on higher doses of tirzepatide beyond the current 15 mg maximum. The studies focus on adults with type 2 diabetes and obesity who are on metformin, aiming to see if higher doses give better results. The phase 2 study is scheduled to conclude in October.
I came across something mentioning patent filings aimed at 20 and 25 milligram strengths. An AI tool mentioned it too, though I didn't verify the sources myself since those systems can make things up. Apparently the manufacturer submitted applications for versions with stronger amounts and higher concentrations of the main compound used in the injections. One international filing from early last year covers formulations that stay stable above the existing thirty milligrams per milliliter level, going as high as sixty. They list options like forty, fifty, fifty-five, and sixty milligrams per milliliter, which in the usual half milliliter shot would allow for twenty, twenty-five, or even thirty milligram totals. The documents point out that many users might gain extra help with weight control past the current fifteen milligram limit, while ensuring the mixtures remain good for half a year and handling any increased stomach issues. This seems to set things up for possibly releasing more potent versions later on, assuming studies confirm they work better for blood sugar or weight with okay safety.
60 mg lets goooooooooo
Thanks for that. It's something I've been curious about but my own research didn't go that far. The patent info is pretty convincing that doses up to 30 mg are at least being considered. With higher-dose semaglutide studies they went quite high and saw a bit more weight loss but also more side effects. A trial focused on non-responders or weak responders would be especially useful since at least 5-10 percent respond poorly even at full doses.
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